A5001174512- COVID-19 Clinical Research Studies
- Reproductive tract infections research
- Liver Disease Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Hepatitis B Virus Studies
- Hepatitis C virus research
- COVID-19 and healthcare impacts
- Synthesis and biological activity
- SARS-CoV-2 and COVID-19 Research
- Bee Products Chemical Analysis
- Liver Disease and Transplantation
- Urinary Tract Infections Management
- Diphtheria, Corynebacterium, and Tetanus
- Toxin Mechanisms and Immunotoxins
- Seaweed-derived Bioactive Compounds
- Facial Nerve Paralysis Treatment and Research
- Metabolism and Genetic Disorders
- Free Radicals and Antioxidants
- Clinical Reasoning and Diagnostic Skills
- Immune responses and vaccinations
- Phytochemicals and Antioxidant Activities
- Vibrio bacteria research studies
- Synthesis and Biological Evaluation
- Echinoderm biology and ecology
- HIV, Drug Use, Sexual Risk
Univerzitetski Klinički Centar Srbije
2023-2025
Institute of Chemistry, Technology and Metallurgy
2021-2024
University of Belgrade
2021-2024
Institute of Virology, Vaccines and Sera “Torlak”
2015-2020
<title>Abstract</title> Evidence about long-term effects of tocilizumab (TCZ) treatment after COVID-19 is sparse. This study explored COVID-19-related outcomes over a two-year period among people who received TCZ and those did not. Patients were recruited from two healthcare centers in Serbia, March 2021 to December 2022. Demographic, clinical, laboratory data collected hospital records. Outcomes years follow-up, such as post-COVID syndrome (PCS) mortality, retrieved records or through...
Introduction: During the coronavirus disease 2019 (COVID-19) pandemic, low- and middle- income countries had less access to monoclonal antibodies, such as tocilizumab (TCZ), compared high-income countries. This retrospective cohort study aimed at evaluating impact of a delayed TCZ administration on patient outcomes, determining optimum timing initiation for COVID-19 pneumonia in Serbia. Methodology: The included 150 patients who received tertiary referral center. outcomes analyzed this were...
Ocular chlamydial infections with the ocular serovars A, B, Ba, and C of Chlamydia trachomatis represent world's leading cause infectious blindness. Carrageenans are naturally occurring, sulfated polysaccharides generally considered safe for food topical applications. can inhibit infection caused by a variety viruses bacteria. To investigate whether iota-carrageenan (I-C) isolated from red alga Chondrus crispus could prevent infection, we assessed if targeted treatment conjunctival mucosa...
Coronavirus disease of 2019 (COVID-19) is a global health problem. The impact chronic liver diseases on the course and outcome COVID-19 still subject research. aim this study was to show characteristics patients with diseases, establish risk factors for unfavourable outcome.
Introduction/Aim: It is not entirely clear what initial symptoms could predict poorer COVID-19 outcomes. The purpose of this study was to identify the associated with need for an intensive care unit (ICU) treatment and having fatal outcomes COVID-19. Methods: A retrospective analysis conducted on patients who were hospitalized in two health facilities (in Belgrade Sombor) from March 2021 April 2022. Data collected electronic medical records. main ICU mortality. Cox proportional hazard model...
This study, conducted at two university-based infectious disease clinics, included 216 patients with chronic hepatitis C. The primary objective was to assess the positive and negative predictive values, sensitivity, specificity of achieving a sustained virological response (SVR) 4 weeks compared 12 post-therapy. results demonstrated maximum sensitivity 100% for SVR after reaching all analyzed genotypes, except genotype 1b treated EBR/GZR therapy, where 75%. Additionally, younger age less...
Quercetin, a well-known flavonoid with significant medicinal potential, was derivatized at the C8 position tetrahydroisoquinoline (THIQ) moiety, and physicochemical pharmacological properties, inhibition antioxidant activity, cytotoxicity of new compounds were evaluated. Physicochemical including lipophilicity, membrane permeability, P-glycoprotein substrate affinity, assessed theoretically using SwissADME software. The metal-chelating ability evaluated on metal ions Fe
We demonstrated that a recombinant banana lectin (rBanLec), which structural characteristics and physiological impacts highly resemble those reported for its natural counterparts, binds murine peritoneal macrophages specifically modulates their functional characteristics. By using rBanLec in concentrations ranging from 1 μg to 10 stimulate resident (RMs) thioglycollate-elicited (TGMs) BALB/c C57BL/6 mice, we have shown effects of stimulation depend on concentration but also the status...
Following infection, the balance between protective immunity and immunopathology often depends on initial infectious load. Several studies have investigated effect of dose; however, mechanism by which dose affects disease outcomes development a immune response is not known. The aim this study was to investigate how modulates local systemic humoral cellular responses during primary ocular chlamydial infection in guinea pig animal model. Guinea pigs were infected instillation Chlamydophila...
The Importance of Holotranscobalamin Measurement Clinically significant vitamin B 12 deficiency can occur even with total levels apparently within normal range. There is an indeterminate zone between approximately 154 and 300 pmol/L where there likely misclassification status if relying on serum . aim the present study was to assess usefulness holotranscobalamin in diagnosis deficiency. Blood samples were collected subjected assays for holotranscobalamin. We examined 32 subjects (n=32, f=18,...
Introduction/Aim: The impact of chronic viral hepatitis on COVID-19 has not been fully clarified yet. aim this paper was to analyze the clinical features, course and outcome in patients with determine risk factors for unfavorable outcome. Methods: A case-control study conducted which case group included suffering from COVID-19, while control liver diseases other etiologies; were matched according stage disease. All subjects treated at Clinic Infectious Tropical Diseases Belgrade 1st March...
Objective: The aim of this study was to assess factors associated with the risk death in men and women individually shed light on new aspects. Patients methods: This retrospective cohort carried out at two healthcare institutions Serbia, involving 457 patients. were categorized based their gender. primary endpoint survival, specifically patient mortality. Demographic clinical information retrieved from electronic health records. Results: Among men, 11.4% required treatment intensive care...
People who inject drugs (PWIDs) experience high rates of hepatitis C virus (HCV) infection, primarily due to needle sharing and limited healthcare access, resulting in a disproportionate disease burden within this population. This prospective study evaluated treatment outcomes 432 adult patients with chronic (CHC) treated direct-acting antivirals (DAAs) at the University Clinical Center Serbia. Patients were categorized into two groups based on history drug addiction: PWIDs (163, 37.7%)...
Bilateral facial nerve palsy (FNP) is a rare condition that idiopathic in only 20%. FNP the most common cranial neuropathy West Nile neuroinvasive disease (WNND) but usually unilateral and few cases of bilateral have been reported. We present case 65-year-old woman with confirmed WNND simultaneous FNP. In August 2022, patient presented ataxia, gait instability, tremor, fever, vomiting. Following admission, due to her cerebrospinal fluid analyses she was diagnosed WNV encephalitis. Her...
Introduction/Aim: So far, the COVID-19 pandemic has seen four major epidemic waves that have affected more than 753 million people. Epidemiological studies confirmed variability of clinical presentation SARS-CoV-2 infection in these waves. During this period, virus mutations contributed to greater challenges regarding treatment and prevention. The aim study is determine differences presentation, laboratory parameters, as well outcome patients suffering from during different caused by...