A5050278824- Atherosclerosis and Cardiovascular Diseases
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Adipokines, Inflammation, and Metabolic Diseases
- Cytomegalovirus and herpesvirus research
- CAR-T cell therapy research
- Inflammasome and immune disorders
- Immune cells in cancer
- Vitamin D Research Studies
- Immune Response and Inflammation
- Neuroinflammation and Neurodegeneration Mechanisms
Medizinische Hochschule Hannover
2021-2024
Universidad de Antioquia
2014-2021
Preterm infants are at high risk of developing neonatal sepsis. γδ T cells thought to be an important set effector in neonates. Here, were investigated a longitudinal cohort preterm neonates using next-generation sequencing, flow cytometry, and functional assays. During the first year life, Vγ9Vδ2 cell subset showed dynamic phenotypic changes elevated levels fetal-derived evident with Single-cell transcriptomics identified HLA-DRhiCD83+ sepsis, which expressed genes related antigen...
Abstract Signaling via interleukin-2 receptor (IL-2R) is a requisite for regulatory T (Treg) cell identity and function. However, it not completely understood to what degree IL-2R signaling required Treg homeostasis, lineage stability function in both resting inflammatory conditions. Here, we characterized spontaneous mutant mouse strain endowed with hypomorphic Tyr129His variant of CD25, the α-chain IL-2R, which resulted diminished expression reduced signaling. Under noninflammatory...
One of the interventional strategies to reestablish immune effector/regulatory balance, that is typically altered in chronic inflammatory diseases (CID), reinforcement endogenous immunomodulatory pathways as one triggered by interleukin (IL)-10. In a recent work, we demonstrated subcutaneous (sc) administration an IL-10/Treg-inducing small molecule-based formulation, using repetitive microdose (REMID) treatment strategy preferentially direct effects regional system, delays progression...
The targeting of proinflammatory pathways has a prophylactic and therapeutic potential on atherosclerotic cardiovascular diseases (CVD). An alternative/complementary strategy is the promotion endogenous atheroprotective mechanisms that are impaired during atherosclerosis progression, such as activity tolerogenic dendritic cells (tolDC) regulatory T (Treg). There need to develop novel low cost, safe effective tolDC/Treg-inducing formulations can be easy translation into clinical settings. We...
Abstract The adoptive transfer of virus-specific T cells (VSTs) represents a therapeutic option for viral infection treatment in immunocompromised patients. Before administration, ex vivo culture enables VST expansion. However, it is unclear how expansion affects the circulation, homing, and intra-tissue migration administered VSTs. We established model immunotherapy acute cytomegalovirus using expanded OT-I CD8 (recognizing SIINFEKL peptide) into Rag2 -/- mice infected with murine (MCMV)...