A5004051862- Radiation Therapy and Dosimetry
- Radiation Detection and Scintillator Technologies
- Advanced Radiotherapy Techniques
- Radiation Effects in Electronics
- Particle Detector Development and Performance
- Nuclear Physics and Applications
- Boron Compounds in Chemistry
- Medical Imaging Techniques and Applications
- Non-Invasive Vital Sign Monitoring
- CCD and CMOS Imaging Sensors
- Atomic and Subatomic Physics Research
- Nuclear physics research studies
German Cancer Research Center
2021-2024
Heidelberg University
2021-2024
National Center for Tumor Diseases
2024
University Hospital Heidelberg
2024
Heidelberger Institut für Radioonkologie
2024
University College London
2019-2020
RWTH Aachen University
2015-2018
University of Silesia in Katowice
2018
Czech Academy of Sciences, Institute of Physics
2018
Jagiellonian University
2018
Abstract Ion-beam radiotherapy is an advanced cancer treatment modality offering steep dose gradients and a high biological effectiveness. These make the therapy vulnerable to patient-setup anatomical changes between fractions, which may go unnoticed. Charged fragments from nuclear interactions of ion beam with patient tissue carry information about quality. Currently, escape undetected. Inter-fractional in-vivo monitoring based on these charged could ion-beam safer more efficient. We...
Ion-beam radiotherapy is a growing cancer treatment modality because it offers superior dose distribution in the patient compared with conventional using X-rays. Thanks to their versatility, application-specific integrated circuits (ASIC) increasingly gain interest for research into ion imaging and ion-beam characterisation. Timepix3 hybrid semiconductor pixel detector, which nanosecond time binning as well dead-time-free noise-free data-driven readout at pitch of 55 µm × µm. In this work,...
Abstract Recently, it has been proposed that a mixed helium/carbon beam could be used for online monitoring in carbon ion therapy. Fully stripped, the two species exhibit approximately same mass/charge ratio and hence potentially accelerated simultaneously synchrotron to energy per nucleon. At nucleon, helium ions have about three times range of ions, which allow simultaneous use treatment imaging. In this work, measurements simulations PMMA phantoms as well anthropomorphic irradiated...
Noninvasive methods to monitor carbon-ion beams in patients are desired fully exploit the advantages of radiotherapy. Prompt secondary ions produced nuclear fragmentations carbon particular interest for monitoring purposes as they can escape patient and thus be detected tracked measure radiation field irradiated object. This study aims evaluate performance secondary-ion tracking detect, visualize, localize an internal air cavity used mimic inter-fractional changes anatomy at different depths...
In-vivo monitoring methods of carbon ion radiotherapy (CIRT) includes explorations nuclear reaction products generated by carbon-ion beams interacting with patient tissues. Our research group focuses on in-vivo CIRT using silicon pixel detectors. Currently, we are conducting a prospective clinical trial as part the In-Vivo Monitoring project (InViMo) at Heidelberg Ion Beam Therapy Center (HIT) in Germany. We an innovative, in-house developed, non-contact fragment tracking system seven...
The purpose of this study is to characterize the magnitude and depth dose buildup in pencil beam scanning proton therapy.We simulate integrated depth-dose curve realistic beams a water phantom using Geant4 Monte Carlo toolkit. We independently electronic protonic components as function energy from 40 400 MeV, both with without an air gap.At clinical energies, over distance about 1 mm leads reduction at basal layer (0.07 mm) by up 6% compared if no effect were present. Protonic reduces 16%...
Abstract Objective. The highly conformal carbon-ion radiotherapy is associated with an increased sensitivity of the dose distributions to internal changes in patient during treatment course. Hence, monitoring methodologies capable detecting such are vital importance. We established experimental setup conditions address a approach based on secondary-fragment tracking for clinically motivated air cavity dimensions homogeneous head-sized PMMA phantom 40 mm depth. Approach. cavities were...
The commissioning and operation of a particle therapy centre requires an extensive set detectors for measuring various parameters the treatment beam. Among key devices are beam range quality assurance. In this work, novel telescope based on plastic scintillator read out by large-scale CMOS sensor is presented. detector made stack 49 sheets with thickness 2-3 mm active area 100 × mm2, resulting in total physical 124.2 mm. This compact design avoids optical artefacts that common other...
Purpose Recently, there has been increasing interest in the development of scintillator‐based detectors for measurement depth–dose curves therapeutic proton beams (Beaulieu and Beddar [2016], Phys Med Biol ., 61 :R305–R343). These allow single beam parameters such as range or reconstruction full three‐dimensional dose distribution. Thus, scintillation could play an important role quality assurance, online monitoring, imaging. However, light output scintillator a function deposition is...
The dose conformity of carbon-ion beam radiotherapy, which allows the reduction deposition in healthy tissue and escalation to tumor, is associated with a high sensitivity anatomical changes during between treatment irradiations. Thus, monitoring inter-fractional crucial ensure conformity, potentially reduce size safety margins around tumor ultimately irradiation tissue. To do so, methods radiotherapy depth using secondary-ion tracking are being investigated. In this work, detection...
Purpose Ion beam radiotherapy offers enhances dose conformity to the tumor volume while better sparing healthy tissue compared conventional photon radiotherapy. However, increased gradient also makes it more sensitive uncertainties. While most important uncertainty source is patient itself, delivery subject Most of proton therapy centers used cyclotrons, which deliver typically a stable over time, allowing continuous extraction beam. Carbon‐ion (CIRT) in contrast uses synchrotrons and...
The superior dose conformity provided by proton therapy relative to conventional x-ray radiotherapy necessitates more rigorous quality assurance (QA) procedures ensure optimal patient safety. Practically however, time-constraints prevent comprehensive measurements be made of the range in water: a key parameter ensuring accurate treatment delivery.
Carbon-ion radiotherapy provides steep dose gradients that allow the simultaneous application of high tumor doses as well sparing healthy tissue and radio-sensitive organs. However, even small anatomical changes may have a severe impact on distribution because finite range ion beams. An in-vivo monitoring method based secondary-ion emission could potentially provide feedback about patient anatomy thus treatment quality. This work aims to prove clinically relevant change in an anthropomorphic...
An experiment investigating gamma emission in hadron therapy was performed at Cyclotron Centre Bronowice (CCB), Cracow, Poland, using two different phantom materials—carbon and poly(methyl methacrylate) PMMA. The measurements were carried out 70 MeV proton beam energy the quanta registered with use of HP Ge detector scintillation anti-Compton shielding. Although primary aim to establish a solid experimental data base for future applications prompt imaging, have also been analyzed regards...
A model explaining the shape of spectral line in 12 C(p, p γ 4.44 ) C nuclear reaction has been applied to data collected during an experiment conducted at Heidelberg Ion-Beam Therapy Center.Spectra were recorded for a graphite target setup, initial proton beam energies 70.54 MeV and 88.97 MeV, which later degraded before reaching main target, detection angles ranging from 90 • 150 .The calculations reproduced experimental determined angular distribution reaction.This article presents...
The Gamma-CCB experiment is focused on investigation of gamma emission in experiments modeling the course hadron therapy. main goal to search for manifestation Bragg peak prompt spectra. Experimental program comprises a series measurements at different proton beam energies and various phantom materials. In two times performed by group so far CCB Cracow HIT Heidelberg, data were taken with energy 70 130 MeV three materials: graphite, poly(methyl methacrylate) PMMA polyoxymethylene POM, order...
Carbon-ion radiotherapy (CIRT) is a highly conformal form of that offers precise dose distributions for cancer treatment. On the other hand, CIRT sensitive to morphological changes in patient anatomy, such as swelling, tumor size variation, or cavity filling. Our research group at German Cancer Research Center has been developing method monitoring along course treatment by tracking nuclear charged fragments emerge from irradiated patients. A non-invasive in-vivo detection system with seven...