A5081127310- Genetics and Neurodevelopmental Disorders
- Pain Mechanisms and Treatments
- Ion channel regulation and function
- Genomic variations and chromosomal abnormalities
- Autism Spectrum Disorder Research
- Heart Rate Variability and Autonomic Control
- Lipid Membrane Structure and Behavior
- Vestibular and auditory disorders
- Neuroscience and Neuropharmacology Research
- Ion Channels and Receptors
Hebrew University of Jerusalem
2015-2024
Abstract Several genes implicated in autism spectrum disorder (ASD) are chromatin regulators, including POGZ . The cellular and molecular mechanisms leading to ASD impaired social cognitive behavior unclear. Animal models crucial for studying the effects of mutations on brain function as well unveiling underlying mechanisms. Here, we generate a specific conditional knockout mouse model deficient Pogz , an risk gene. We demonstrate that mice show microcephaly, growth impairment, increased...
Abstract Endogenous inflammatory mediators contribute to the pathogenesis of pain by acting on nociceptors, specialized sensory neurons that detect noxious stimuli. Here, we describe a new factor mediating pain. We show platelet-derived growth (PDGF)-BB applied in vitro causes repetitive firing dissociated nociceptor-like rat dorsal root ganglion and decreased their threshold for action potential generation. Injection PDGF-BB into paw produced nocifensive behavior rats led thermal mechanical...
Corticotropin-releasing factor (CRF) is a neuromodulator closely associated with stress responses. It synthesized and released in the central nervous system by various neurons, including neurons of inferior olive. The targets olivary cerebellar Purkinje (PNs), are endowed CRF receptors. increases excitability PNs vivo, but biophysical mechanism not clear. Here we examine effect on firing properties using acute rat slices. increased PN rate, regardless whether they were tonically or switching...
Abstract Pain hypersensitivity is associated with increased activity of peripheral and central neurons along the pain neuroaxis 1 . On other hand, in neuronal systems, leads to adaptive reduction excitability maintain homeostasis 2–4 Projection (PNs) spinal medullary dorsal horns summate primary nociceptive local interneurons convey it higher centers 5 We show that at peak acute inflammatory pain, PNs reduce their intrinsic and, consequently, action potential firing. When resolves, returns...
Abstract Genes implicated in autism spectrum disorder (ASD) are enriched with chromatin regulators, but the mechanisms leading to abnormal behavior and cognition still unclear. Animal models crucial for studying effects of mutations on brain function behavior. We generated conditional knockout mice brain-specific mutation Pogz , a heterochromatin regulator recurrently mutated ASD other neurodevelopmental disorders, demonstrated that these display phenotypes resemble human condition....