A5070474287- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Cancer-related gene regulation
- Cancer Cells and Metastasis
- Lung Cancer Research Studies
- Nigella sativa pharmacological applications
- Neuroendocrine Tumor Research Advances
- Metal complexes synthesis and properties
- Neuroblastoma Research and Treatments
- Characterization and Applications of Magnetic Nanoparticles
- Ubiquitin and proteasome pathways
- Phytochemistry and Bioactivity Studies
- Pharmacological Effects of Natural Compounds
- Antenna Design and Analysis
- Metastasis and carcinoma case studies
- Histone Deacetylase Inhibitors Research
- Protein Degradation and Inhibitors
- Graphene and Nanomaterials Applications
- CRISPR and Genetic Engineering
- Chromosomal and Genetic Variations
- Pluripotent Stem Cells Research
- Cytokine Signaling Pathways and Interactions
- RNA modifications and cancer
Karolinska Institutet
2023-2024
University Hospital Ulm
2016-2023
Indian Institute of Science Bangalore
2011-2014
Universität Ulm
2014
Vellore Institute of Technology University
2010
Abstract The adsorption of serum proteins, leading to the formation a biomolecular corona, is key determinant biological identity nanoparticles in vivo. Therefore, gaining knowledge on formation, composition, and temporal evolution corona utmost importance for development nanoparticle‐based therapies. Here, it shown that use super‐resolution optical microscopy enables imaging protein mesoporous silica with single sensitivity. Particle‐by‐particle quantification reveals significant...
The Bmi1 polycomb ring finger oncogene, a transcriptional repressor belonging to the Polycomb group of proteins plays an important role in regulation stem cell self-renewal and is elevated several cancers. In current study, we have explored regulating stemness drug resistance breast cancer cells. Using real time PCR immunohistochemistry primary tissues were analyzed. Retro- lentiviruses utilized overexpress knockdown Bmi1, RT-PCR Western blot was performed evaluate mRNA protein expression....
Acute leukemia is initiated and maintained by stem cells (LSCs) therefore there great interest to develop innovative therapeutic approaches which target LSCs. Here we show that mesoporous silica nanoparticles (MSNs) functionalized with succinic anhydride, tagged an anti-B220 antibody loaded the anthracycline daunorubicin are efficiently incorporated into murine B220-positive AML LSCs preferentially kill these in comparison B220-negative vitro. Furthermore, short - term treatment of MSNs...
The functionalization of nanoparticles with a ligand targeting receptors overexpressed by the target cells is commonly used strategy when aiming at nanoparticle-based, cell type-specific drug delivery.1-4 However, influence particle surface chemistry on targetability has received much less attention. charge known to directly or indirectly affect nanoparticle cellular uptake kinetics influencing serum protein adsorption.5-7 Thus, it fair assume that both specificity and targeted are...
Neuroblastoma (NB), the most frequent solid extracranial tumor in children, is not always cured by current aggressive therapies that have notable adverse effects; therefore, novel treatments are necessary. Phosphoinositide 3‑kinase (PI3K) and fibroblast growth factor receptor inhibitors exhibit synergistic effect NB cell lines. In present study, mono‑ combination therapy of United States Food Drug Administration‑approved PI3K, cyclin‑dependent kinase‑4/6 (CDK4/6), poly‑ADP‑ribose‑polymerase...
Homeobox genes are key regulators in normal and malignant hematopoiesis. The human Vent-like homeobox gene VENTX, a putative homolog of the Xenopus laevis Xvent-2 gene, was shown to be highly expressed myeloid cells patients with acute leukemia. We now demonstrate that constitutive expression VENTX suppresses responsible for terminal erythroid differentiation CD34+ stem progenitor cells. Transplantation bone marrow retrovirally engineered express caused massive expansion primitive partly...
Key Points CDX4 induces AEL in mice and suppresses expression of genes associated with erythroid differentiation. Mutations detectable the Cdx4-induced model occur reported mutated patients AEL.