A5082614090- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Infant Nutrition and Health
- Pharmacological Effects of Natural Compounds
- Eosinophilic Esophagitis
- Herbal Medicine Research Studies
- Ginseng Biological Effects and Applications
- Escherichia coli research studies
- T-cell and B-cell Immunology
- Antimicrobial Peptides and Activities
- Gut microbiota and health
- Breastfeeding Practices and Influences
- Immunotherapy and Immune Responses
- Pediatric health and respiratory diseases
- Asthma and respiratory diseases
- Sphingolipid Metabolism and Signaling
The University of Tokyo
2013-2022
National Institute of Biomedical Innovation, Health and Nutrition
2019-2022
University of California, San Diego
2018-2022
Fucosylation of intestinal epithelial cells, catalyzed by fucosyltransferase 2 (Fut2), is a major glycosylation mechanism host-microbiota symbiosis. Commensal bacteria induce fucosylation, and fucose used as dietary carbohydrate many these bacteria. However, the molecular cellular mechanisms that regulate induction fucosylation are unknown. Here, we show type 3 innate lymphoid cells (ILC3) induced Fut2 expression in mice. This required cytokines interleukin-22 lymphotoxin commensal...
Paneth cells are intestinal epithelial that release antimicrobial peptides, such as α-defensin part of host defense. Together with mesenchymal cells, provide niche factors for stem cell homeostasis. Here, we report two subtypes murine differentiated by their production and utilization fucosyltransferase 2 (Fut2), which regulates α(1,2)fucosylation to create cohabitation niches commensal bacteria prevent invasion the intestine pathogenic bacteria. The majority Fut2- were localized in...
Fucosylated glycans on the surface of epithelial cells (ECs) regulate intestinal homeostasis by serving as attachment receptors and a nutrient source for some species bacteria. We show here that fucosylation in ileum is negatively regulated IL-10-producing CD4(+) T cells. The number fucosylated ECs was increased mice lacking cells, especially those expressing αβ cell receptor (TCR), CD4, IL-10. No such effect observed B Adoptive transfer αβTCR(+) from normal mice, but not IL-10-deficient...