A5064190399- Pelvic floor disorders treatments
- Pluripotent Stem Cells Research
- 3D Printing in Biomedical Research
- Neuroscience and Neural Engineering
- Urinary Tract Infections Management
- Congenital heart defects research
- Urinary Bladder and Prostate Research
- Ovarian function and disorders
- Sexual function and dysfunction studies
- Barrier Structure and Function Studies
- Retinal Development and Disorders
- Retinal Diseases and Treatments
- CRISPR and Genetic Engineering
Sun Yat-sen University
2018-2024
Fifth Affiliated Hospital of Sun Yat-sen University
2020
Abstract Accumulated oxidative damage may lead to irreversible retinal pigmented epithelium (RPE) cell death, which is considered be the primary cause of dry age-related macular degeneration (AMD), leading blindness in elderly. However, an effective therapy for this disease lacking. Here, we described a robust high-content screening procedure with library 814 protective compounds and found that D609 strongly protected RPE cells from sodium iodate (SI)-induced death prolonged their healthy...
Definitive endoderm (DE) derived from human pluripotent stem cells (hPSCs) holds great promise for cell-based therapies and drug discovery. However, current DE differentiation methods required undefined components and/or expensive recombinant proteins, limiting their scalable manufacture clinical use. Homogeneous in defined protein-free conditions remains a major challenge. Here, by systematic optimization high-throughput screening, we report chemically defined, small-molecule-based system...