A5032185602- Connective tissue disorders research
- Orthopaedic implants and arthroplasty
- Bone fractures and treatments
- Bone health and osteoporosis research
- Bone Tissue Engineering Materials
- Elasticity and Material Modeling
- Dental Implant Techniques and Outcomes
- Hip and Femur Fractures
- Bone and Dental Protein Studies
- Dental materials and restorations
- Hip disorders and treatments
- Orthopedic Infections and Treatments
University of Bern
2019-2024
Osteogenesis imperfecta (OI) is an inheritable, genetic, and collagen-related disorder leading to increase in bone fragility, but the origin of its "brittle behavior" unclear. Because complex hierarchical structure, behaves differently at various length scales. This study aims compare mechanical properties human OI with healthy control extracellular matrix (ECM) level quantify influence degree mineralization. Degree mineralization were analyzed under dry conditions 12 fixed embedded...
Current clinical methods of bone health assessment depend to a great extent on mineral density (BMD) measurements. However, these only act as proxy for strength and are often carried out after the fracture occurs. Besides BMD, composition tissue-level mechanical properties expected affect whole bone's toughness. While elastic extracellular matrix (ECM) have been extensively investigated over past two decades, there is still limited knowledge yield their relationship architecture. In present...
Osteogenesis imperfecta (OI) is a genetic, collagen-related bone disease that increases the incidence of fractures. Still, origin this brittle mechanical behavior remains unclear. The extracellular matrix (ECM) OI exhibits higher degree mineralization (DBM), whereas compressive properties at ECM level do not appear to be inferior healthy bone. However, it unknown if collagen defects alter tensile properties. This study aims quantify and ECM. In three transiliac biopsies (healthy n = 1, type...
High-resolution peripheral quantitative computed tomography (HR-pQCT) based micro-finite element (μFE) analysis allows accurate prediction of stiffness and ultimate load standardised (~1 cm) distal radius tibia sections. An alternative homogenized finite method (hFE) was recently validated to compute the larger (~2 sections that include Colles' fracture sites. Since mechanical integrity weight-bearing is gaining clinical interest, it has been shown same properties can be used predict...
Preclinical studies often require animal models for in vivo experiments. Particularly dental research, pig species are extensively used due to their anatomical similarity humans. However, there is a considerable knowledge gap on the multiscale morphological and mechanical properties of miniature pigs' jawbones, which crucial implant direct comparison human tissue. In present work, we demonstrate multimodal framework assess jawbone quantity quality minipig model that could be further extended...
Tissue fixation is a prevalent method for bone conservation. Bone biopsies are typically fixed in formalin, dehydrated ethanol, and infiltrated with polymethyl methacrylate (PMMA) Since some experiments can only be performed on samples, it essential to understand how affects the measured material properties. The aim of this study was quantify influence tissue mechanical properties cortical ovine at extracellular matrix (ECM) level state-of-the-art micromechanical techniques. A small section...
HR-pQCT based micro finite element (μFE) analyses are considered as "gold standard" for virtual biomechanical of peripheral bone sites such the distal segment radius and tibia. An attractive alternative clinical use is a homogenized method (hFE) on constitutive models, because its much shorter evaluation times modest computational resource requirements. Such hFE models have been experimentally validated radius, but neither segments tibia nor both measurement together. Accordingly, aim...
Osteogenesis Imperfecta (OI) is an inherited form of bone fragility characterised by impaired synthesis type I collagen, altered trabecular architecture and reduced mass. High resolution peripheral computed tomography (HR-pQCT) a powerful method to investigate morphology at sites including the weight-bearing distal tibia. The resulting 3D reconstructions can be used as basis micro-finite element (FE) or homogenized finite (hFE) models for strength estimation. hFE scheme uses local volume...