A5082913208- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Acute Lymphoblastic Leukemia research
- Cancer-related gene regulation
- Chronic Myeloid Leukemia Treatments
- Retinoids in leukemia and cellular processes
- Chronic Lymphocytic Leukemia Research
- Zebrafish Biomedical Research Applications
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Neutropenia and Cancer Infections
- Protein Degradation and Inhibitors
- RNA Research and Splicing
- Cancer-related Molecular Pathways
- Cancer Genomics and Diagnostics
- Viral-associated cancers and disorders
- Hematological disorders and diagnostics
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Immunodeficiency and Autoimmune Disorders
- Histone Deacetylase Inhibitors Research
- Hematopoietic Stem Cell Transplantation
- Pneumocystis jirovecii pneumonia detection and treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Autoimmune and Inflammatory Disorders Research
Kyoto Prefectural University of Medicine
2007-2023
Juntendo University Shizuoka Hospital
2014
RIKEN Center for Integrative Medical Sciences
2008
Japan Science and Technology Agency
2005-2008
Target (United States)
2007
St. Jude Children's Research Hospital
1992-1998
University of Tennessee Health Science Center
1994
Saiseikai Suita Hospital
1991
Children's Research Hospital
1991
Mouse CD4 + CD8 double-positive (DP) thymocytes differentiate into helper-lineage cells upon expression of the transcription factor Th-POK but commit to cytotoxic lineage in its absence. We report redirected differentiation class I–restricted – helper-like T loss Runx complexes. A Runx-binding sequence within locus acts as a transcriptional silencer that is essential for repression and development cells. Thus, genetic programming helper cell are actively inhibited by Runx-dependent activity,...
Mrg class G-protein-coupled receptors (GPCRs) are expressed exclusively in sensory neurons the trigeminal and dorsal root ganglia. Pharmacological activation of proteins is capable modulating neuron activities elicits nociceptive effects. In this study, we illustrate a control mechanism that allows Runx1 runt domain transcription factor to generate compartmentalized expression these GPCRs. Expression MrgA , MrgB MrgC subclasses confined an “A/B/C” neuronal compartment expresses transiently...
Abstract We describe a patient who had aggressive natural killer cell leukemia with profound hemophagocytosis. This combination must be underscored as one of several hemophagocytic syndromes. Activated phagocytes in the bone marrow appeared morphologically normal and could possibly proliferating response to some cytokine(s) such interferon‐gamma produced by leukemic cells, whose serum level was found extremely elevated this case.
AML1 is one of the most frequently mutated genes associated with human acute leukemia and encodes DNA-binding subunit heterodimering transcriptional factor complex, core-binding (CBF) (or polyoma enhancer binding protein 2 [PEBP2]). A null mutation in either or its dimerizing partner, CBFβ, results embryonic lethality secondary to a complete block fetal liver hematopoiesis, indicating an essential role this transcription complex development definitive hematopoiesis. The hematopoietic...
In this study, we analyzed the roles for AML1/RUNX1 in regulation of c-mpl promoter. Wild-type AML1 activated promoter through proximal AML-binding site luciferase assays using 293T and HeLa cells. accord with result, electrophoretic mobility shift assay chromatin immunoprecipitation demonstrated that bound to site. Next, function a mutant lacking C terminus (AML1dC), which was originally found patient myelodysplastic syndromes. AML1dC dominant-negatively suppressed transcriptional activity...
In our chromosome study of 97 patients with myelodysplastic syndrome (MDS), six showed an unbalanced translocation between chromosomes 1 and 7 [-7, +der(1)t(1;7)(p11;p11)]. All them had morphologic myelodysplasia in trilineage bone marrow cells, cytopenia was the major finding peripheral blood. symptoms infection at time diagnosis, five immunologic abnormalities (polyclonal hypergammaglobulinemia four increased plasma cells three). None survived more than 11 months after diagnosis; median...
Th-inducing Pox virus and zinc finger/Krüppel-like factor (ThPOK) is a key commitment for CD4(+) lineage T cells essential the maintenance of CD4 integrity; thus, expression ThPOK has to be tightly controlled. In this article, we demonstrate that Myc-associated finger-related (MAZR) Runt-related transcription 1 (Runx1) together repressed in preselection double-positive thymocytes, whereas MAZR acted synergy with Runx3 repression CD8(+) cells. Furthermore, MAZR-Runx1 MAZR-Runx3 double-mutant...
Summary AML1/RUNX1 , which encodes a transcription factor essential for definitive haematopoiesis, is frequent target of leukaemia‐associated chromosome translocations. Point mutations this gene have also recently been associated with leukaemia and myelodysplastic syndrome (MDS). To further define the frequency biological characteristics AML1 mutations, we examined 170 cases such diseases. Mutations within runt ‐domain were identified in five cases: one de novo acute myeloid (AML) four MDS....
RUNX1 (previously termed AML1) is a frequent target of human leukaemia-associated gene aberrations, and it encodes the DNA-binding subunit Core-Binding Factor transcription factor complex. expression essential for initiation definitive haematopoiesis, steady-state thrombopoiesis, normal lymphocytes development. Recent studies revealed that protein arginine methyltransferase 1 (PRMT1), which accounts majority type I PRMT activity in cells, methylates two residues (R206 R210), these...
Connexin 43 (Cx43) functions as a cell growth suppressor. We have demonstrated that Cx43 interacts with heat shock cognate protein 70 (Hsc70) for regulating proliferation. Hsc70 CDK inhibitor p27, which regulates the assembly and subcellular localization of cyclin D1-CDK4-p27 complex. However, involvement p27 Cx43-mediated cycle suppression is still poorly understood. Here, we report nuclear accumulation reduced by overexpression Cx43, this reduction restored co-overexpression Hsc70. found...