Usher syndrome (USH) is the most common cause of inherited deaf-blindness, manifested as USH1, USH2 and USH3 clinical types. The protein products causative modifier genes, USH2A, ADGRV1, WHRN PDZD7, interact to assemble a multiprotein complex at ankle link region mechanosensitive stereociliary bundle in hair cells. Defects this disorganization hearing loss. four proteins also vitro with USH1 including myosin VIIa, USH1G (SANS), CIB2 harmonin. However, it unclear whether interactions between...

Surface expression and release of α-tectorin are required for the organization collagen bundles tectorial membrane.

Usher syndrome (USH) is the leading cause of inherited deaf-blindness, with type 2 (USH2) being most common clinical form. Studies suggest that proteins encoded by USH2 causative genes assemble into ankle link complex (ALC) at hair cell stereociliary bundle; however, little known about in vivo assembly and function this complex. Using various mutant mice, we showed immunofluorescence play different roles cochlear ALC assembly, G protein-coupled receptor 98 important protein. Complex likely...

Usher syndrome (USH) is the most common inherited deaf-blindness with majority of USH causative genes also involved in nonsyndromic recessive deafness (DFNB). The mechanism underlying this disease variation unclear. Here, we addressed issue by investigating DFNB31 gene, whose mutations cause USH2D or depending on their position. We found that mouse ortholog (Dfnb31) expressed different mRNA variants and whirlin protein isoforms cochlea retina, where these played roles spatially temporally....

Audiovestibular symptoms during the acute stage have been reported in patients with severe respiratory syndrome coronavirus 2 (SARS-CoV-2), while very few studies investigated long-term audiovestibular manifestations of SARS-CoV-2.The objective this study was to examine occurrence short- and associated SARS-CoV-2 infection.In cross-sectional study, a questionnaire distributed hospitalized cases nonhospitalized mild disease, all confirmed test results. Participants were inquired report phase...

Honey has a history of medical use and is known as bio-alternative therapy. This research assessed the phytochemical biological activity grade manuka honey (MH). Gas chromatography–mass spectrometry (GC–MS) was chosen to investigate bioactive compounds MH. The DPPH ABTS free radical scavenging beta-carotene antioxidant activities well antibacterial antibiofilm effects against S. aureus, B. subtilis, E. coli P. aeruginosa were all determined. Furthermore, gauge anticancer properties MH, MTT...

Educational institutions in Saudi Arabia extended e-learning until the third semester of academic calendar to prevent spread COVID-19 infection and achieve 70% inoculation for population. This study assesses impact other associated stressors on emotional health university students Arabia. An online cross-sectional survey collected data between months January-March 2021. The signs stress were measured by using a subset items from Adolescent Symptom Psychological Experience Questionnaire...

Congenital cytomegalovirus (CMV) infection is the most common non-hereditary cause of sensorineural hearing loss (SNHL) yet mechanisms remain obscure. Natural Killer (NK) cells play a critical role in regulating murine CMV via NK cell recognition Ly49H surface receptor viral-encoded m157 ligand expressed at infected surface. This receptor/m157 interaction has been found to mediate host resistance spleen, and lung, but much less effective liver, so it not known if this important context SNHL....

During the initial phases of COVID-19 pandemic, stress and anxiety were pervasive among masses due to high morbidity mortality. Besides fear coronavirus was also particularly driven by social media. Many people started look for faith spiritual connections gain comfort. The role ties religious beliefs in relation coping with pandemic has acquired attention researchers some parts world. This cross-sectional survey aimed at assessing intensity symptoms experienced how much they alleviated...

Amplitude modulation (AM) detection was measured with a short (50 ms), high-frequency carrier as function of level (Experiment I) and frequency II) for conditions or without notched-noise precursor. A longer (500 ms) also included in Experiment I. When the preceded by silence (no precursor condition) AM thresholds worsened moderate-level carriers compared to lower- higher-level carriers, resulting “mid-level hump.” were better than those precursor, primarily moderate-to-high thus eliminating...

Audiovestibular symptoms during the acute phase of corona virus disease 2019 (COVID-19), have been reported for earlier waves pandemic, while no studies investigated nor compared audiovestibular manifestations subsequent COVID-19. In current study, we aimed to compare occurrence associated with COVID-19 between alpha/beta, delta, and omicron variants. An online questionnaire was distributed individuals confirmed test results We asked participants report whether they experienced disease. The...

Objectives The goal of the study was to determine whether reactive oxygen species (ROS) mediates cytomegalovirus (CMV)–induced labyrinthitis. Study Design Murine model CMV infection. Setting University Utah laboratory. Subjects and Methods Nrf2 knockout mice were inoculated with murine CMV. Auditory brainstem response (ABR) distortion product otoacoustic emissions (DPOAEs) then performed on these uninfected controls. BALB/c a marker for ROS production, dihydroethidium (DHE), is expressed 7...

Background: Cognitive flexibility (CF) in the psychological literature has been described as an individual’s ability to produce several solutions and retain control novel situations. Recently, COVID-19 pandemic appeared be ideal scenario that demanded application of adaptive thinking by students deal with challenges pandemic. Aim: This study aimed assess role CF reducing academic stress among university due sudden strict implementation online education during Methods: employed a...

Cytomegalovirus (CMV) is the most common intrauterine congenital infection in humans. Worldwide seropositive rates of CMV are considerably high among women childbearing age. There currently no optimal drug treatment nor a vaccine for and therefore best available program to date prevention practicing standard hygienic measures. The success this relies on women's knowledge modes transmissions, risk preventative behaviors.The current study aims assess awareness Saudi Arabia.In cross-sectional...

Objective The objective of this study was to determine the prevalence, risk factors, and audiological characteristics auditory neuropathy spectrum disorder (ANSD) in pediatric population.Design A retrospective review medical charts conducted for children visiting two hospitals Saudi Arabia.Study Sample Medical records 1025 patients with sensorineural hearing loss (SNHL) were reviewed. We analyzed databases results examinations, outcomes intervention including aid (HA) cochlear implantation...

Coronavirus disease 2019, caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is a communicable transmitted through route and bodily contact. The severity of infection mortality rate COVID-19 cases was significantly high in initial stages pandemic. This study aims to investigate hematological profile survivors non-survivors.This single-center retrospective study. A total 108 hospitalized patients with laboratory-confirmed at East Jeddah Hospital between April August...

University students with disabilities face an increased risk of experiencing negative implications in educational, psychological, and social spheres during the COVID-19 pandemic. This study aimed at assessing various dimensions support its sources pandemic that availed university disabilities. cross-sectional descriptive collected data from 53 We administered Social Support Scale (SSC) to assess five dimensions: informational, emotional, esteem, integration tangible support, access four...

The acoustic waveform of speech is characterized by slowly varying amplitude fluctuations (i.e., envelope) and an accurate representation the envelope essential for understanding. post-cochlear contrast between peaks valleys (peak-to-valley contrast) may be reduced cochlear compression. This study tested (1) whether modulation (AM) detection thresholds are consistent with compression (2) introduction a precursor before carrier results in improved AM thresholds, decompressed response via...

Bacterial coinfection among patients with confirmed coronavirus disease 2019 (COVID-19) is a critical medical concern that increases the severity and mortality rate. The current study aimed at evaluating effects of bacterial coinfections COVID-19 patients, especially in relation to degree mortality. A retrospective was conducted for positive test, admitted regional hospital Jeddah, Saudi Arabia, between May August 2020. specimen (e.g., blood, urine, or sputum) collected from COVID-19,...

Abstract Adenylyl cyclase 6 (AC6) synthesizes second messenger cAMP in G protein-coupled receptor (GPCR) signaling. In cochlear hair cells, AC6 distribution relies on an adhesion GPCR, ADGRV1, which is associated with Usher syndrome (USH), a condition of combined hearing and vision loss. ADGRV1 component the USH type 2 (USH2) protein complex cells photoreceptors. However, role inner ear retina has not been explored. Here, we found that depends USH2 integrity. Several known regulators...

Amplitude modulation (AM) detection measures a listener's sensitivity to temporal envelope fluctuations. AM signals are ecologically relevant because the amplitude of speech fluctuates over time. The post-cochlear representation may be influenced by processes that occur in cochlea, where subject cochlear compression and adaptive mechanisms modulate response such as medial olivocochlear (MOC) reflex. Specifically, reduce difference between high-intensity peaks low-intensity valleys (i.e.,...