A5100424380- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Vestibular and auditory disorders
- Ion Channels and Receptors
- Connexins and lens biology
- Neural dynamics and brain function
- Heat shock proteins research
- Neurobiology and Insect Physiology Research
- Noise Effects and Management
- Parkinson's Disease Mechanisms and Treatments
- Retinal Development and Disorders
- Biochemical effects in animals
- Ear Surgery and Otitis Media
- 3D Printing in Biomedical Research
- Neuroscience and Neural Engineering
- Bat Biology and Ecology Studies
- Photoreceptor and optogenetics research
- Coccidia and coccidiosis research
- Ion channel regulation and function
- Exercise and Physiological Responses
- Neuroinflammation and Neurodegeneration Mechanisms
- Phytochemicals and Antioxidant Activities
- Olfactory and Sensory Function Studies
University of Utah
2010-2023
First Affiliated Hospital of Anhui Medical University
2021-2022
Anhui Medical University
2021-2022
The Ohio State University
2019-2021
Zero to Three
2021
Soochow University
2020
First Affiliated Hospital of Soochow University
2020
Huazhong University of Science and Technology
2013
Qingdao University
2013
China Medical University
2009-2010
Every year, 30,000 babies are born with congenital hearing impairment in China. The molecular etiology of the Chinese population has not been investigated thoroughly. To provide appropriate genetic testing and counseling to families, we performed a comprehensive investigation nonsyndromic deafness two typical areas from northern southern China.A total 284 unrelated school children loss who attended special education schools China were enrolled this study, 134 Chifeng City Inner Mongolia...
Usher syndrome type 2 (USH2) is the predominant form of USH, a leading genetic cause combined deafness and blindness. PDZD7, paralog two USH causative genes, USH1C USH2D (WHRN), was recently reported to be implicated in USH2 non-syndromic deafness. It encodes protein with multiple PDZ domains. To understand biological function PDZD7 pathogenic mechanism caused by mutations, we generated thoroughly characterized Pdzd7 knockout mouse model. The mice exhibit congenital profound deafness, as...
Abstract Olfactory dysfunction is one of the early symptoms seen in Parkinson’s disease (PD). However, mechanisms underlying olfactory pathology that impacts PD progression and post‐mortem appearance alpha‐Synuclein (α‐Syn) inclusions beyond bulb remain unclear. It has been suggested environmental toxins inhaled through nose can induce inflammation (OB), where Lewy body (LB) first to be found, then, spread related brain regions. We hypothesize OB triggers local α‐Syn promotes its spreading...
Age-related hearing loss (AHL) typically starts from high-frequency regions of the cochlea and over time invades lower-frequency regions. During this progressive loss, sound-evoked activity in spiral ganglion cells is reduced. DBA mice have an early onset AHL. In study, we examined synaptic transmission at endbulb Held synapse between auditory nerve fibers bushy anterior ventral cochlear nucleus (AVCN). Synaptic hearing-impaired areas AVCN was altered old mice. The spontaneous miniature...
Cataracts are a serious complication of diabetes. In long-term hyperglycemia, intracellular Ca2+ concentration ([Ca2+]i) and reactive oxygen species (ROS) increased. The apoptosis lens epithelial cells plays key role in the development cataract. We investigated potential for transient receptor vanilloid 2 (TRPV2) diabetic cataracts. Immunohistochemical Western blotting analyses showed that TRPV2 expression levels were significantly increased patients with cataracts as compared senile...
We investigated the expression of transient receptor potential canonical 6 (TRPC6) protein in benign and malignant human prostate tissues cancer cell lines association with stage, grade androgen responsiveness tumors. Immunohistochemical techniques, Western blot reverse transcription polymerase chain reaction (RT-PCR) were used to investigate TRPC6 expression. was detected 9 20 (45.0%) prostatic hyperplasia (BPH) cases, there a significant difference compared (129 149 [86.6%])(P < 0.01)....
Hepatocyte growth factor (HGF) is a glycoprotein that induces prostate cancer cell proliferation, migration and invasion. The activation of transient receptor potential canonical 6 (TRPC6) channels considered important in promoting proliferation. In this study, we assessed the role endogenous TRPC6 HGF-induced proliferation cancer. Reverse transcription-PCR Western blotting were used to investigate expression. Electrophysiological techniques (whole-cell patch clamp configuration) Ca(2+)...
Usher syndrome (USH) is the leading cause of inherited deaf-blindness, with type 2 (USH2) being most common clinical form. Studies suggest that proteins encoded by USH2 causative genes assemble into ankle link complex (ALC) at hair cell stereociliary bundle; however, little known about in vivo assembly and function this complex. Using various mutant mice, we showed immunofluorescence play different roles cochlear ALC assembly, G protein-coupled receptor 98 important protein. Complex likely...
Key points Sound information is transmitted by different subtypes of spiral ganglion neurons (SGN) from the ear to brain. Selective damage SGN peripheral synapses (cochlear synaptopathy) widely recognized as one primary mechanisms hearing loss, whereas at central remain unclear. We report that converge ratios onto individual target cochlear nucleus with distinct physiological properties, and show biased morphological changes during age‐related loss (ARHL). The results reveal a new dimension...
Aims: The transient receptor potential canonical channel 1 (TRPC1) is a crucial component of the stretch-activated ion channels (SACs). objective this research was to demonstrate contribution TRPC1 in maintaining cardiac contractile function hypertrophic myocardium. Methods: Hypertrophic rat hearts were induced by injecting isoproterenol intraperitoneally, and expressions TRPC1/3/6 Na+/Ca2+ exchanger (NCX1) proteins analyzed Western blot. intracellular calcium images, action myocardium,...
It is estimated that hearing loss currently affects more than 1.5 billion people, or approximately 20% of the global population; however, presently, there are no Food and Drug Administration-approved therapeutics prophylactics for this condition. While continued research on development otoprotective drugs to target clear unmet need an obvious path, numerous challenges translating promising therapeutic candidates into human clinical testing. The screening drug relies exclusively preclinical...
Age-related hearing loss (ARHL) is associated with weakened inhibition in the central auditory nervous system including cochlear nucleus. One of main inhibitory neurons nucleus D-stellate neuron, which provides extensive glycinergic within local neural network. It remains unclear how physiological activities change during ARHL and what are underlying mechanisms. Using vitro whole-cell patch clamp technique, we studied intrinsic membrane properties neurons, changes their firing properties,...
Precisely engineered neuronal circuits are promising for both fundamental research and clinical applications. However, randomly plating thousands of cells during neural network fabrication remains a major technical obstacle, which often results in loss tracking neurons' identities. In this work, we demonstrated an accurate unique wiring technique, mimicking natural affinity to microfibers. SU-8 microridges, imitating lie-down microfibers, were photolithographically patterned then selectively...
It is known that Kv1.3, KCa3.1, CRAC, TRPM7, and Clswell are five important ion channels in T lymphocytes. To investigate the mechanism underlying protective effects of lentinan against lymphocytes injury induced by chronic radiation mice, we determined expression profiles Orai1, STIM1, genes. Mice were injected with different concentrations before exposure to 60Co g-ray. Total RNA was then extracted from murine spleen. The Real time-PCR per- formed detect levels results show that, out six...
SUMMARY Sound information is transmitted from the cochlea to brain by different subtypes of spiral ganglion neurons (SGN), which show varying degrees vulnerbility under pathological conditions. It remains unclear how these SGNs reassemble among target in cochlear nucleus (CN) at auditory nerve (AN) central synapses, and synapses change during hearing loss. Combining immunohistochemistry with electrophysiology, we investigated giant endbulb Held their postsynaptic bushy mice normal...