A5072378782- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- Supramolecular Self-Assembly in Materials
- RNA Interference and Gene Delivery
- Advanced Polymer Synthesis and Characterization
- Metal-Organic Frameworks: Synthesis and Applications
- Coordination Chemistry and Organometallics
- Electronic Packaging and Soldering Technologies
- Intermetallics and Advanced Alloy Properties
- Covalent Organic Framework Applications
- Block Copolymer Self-Assembly
- Aluminum Alloys Composites Properties
- Polymer Surface Interaction Studies
- Luminescence and Fluorescent Materials
- Catalytic Cross-Coupling Reactions
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
McGill University
2022-2025
Texas A&M University at Qatar
2017-2018
ConspectusStructural DNA nanotechnology offers a unique self-assembly toolbox to construct soft materials of arbitrary complexity, through bottom-up approaches including origami, brick, wireframe, and tile-based assemblies. This can be expanded by incorporating interactions orthogonal base-pairing such as metal coordination, small molecule hydrogen bonding, π-stacking, fluorophilic interactions, or the hydrophobic effect. These allow for hierarchical long-range organization in supramolecular...
The self-assembly of block copolymers is often rationalized by structure and microphase separation; pathways that diverge from this parameter space may provide new mechanisms polymer assembly. Here, we show the sequence length single-stranded DNA directly influence sequence-defined copolymers. While increasing led to predictable changes in self-assembly, changing only produced three distinct structures: spherical micelles (spherical nucleic acids, SNAs) flexible poly(thymine) DNA, fibers...
Abstract Biopolymers such as nucleic acids and proteins exhibit dynamic backbone folding, wherein site-specific intramolecular interactions determine overall structure. Proteins then hierarchically assemble into supramolecular polymers microtubules, that are robust yet dynamic, constantly growing or shortening to adjust cellular needs. The combination of energy-driven folding growth with structural stiffness length control is difficult achieve in synthetic polymer self-assembly. Here we show...
Abstract Two‐dimensional (2D) assemblies of water‐soluble block copolymers have been limited by a dearth systematic studies that relate polymer structure to pathway mechanism and supramolecular morphology. Here, we employ sequence‐defined triblock DNA amphiphiles for the polymerization free‐standing nanosheets in water. Our modulation amphiphile sequence shows alkyl chain core forming cell membrane‐like distal π‐stacking chromophore folding back interact with hydrophilic on nanosheet...
This paper reports the efficient synthesis of first class polyisobutylene(PIB)‐supported palladium‐PEPPSI precatalyst (PEPPSI = pyridine‐enhanced preparation, stabilization, and initiation). The new complexes are employed in Buchwald–Hartwig amination aryl chlorides found to be reasonably active titled cross‐coupling reaction. supported catalysts tested polar (1,4‐dioxane 1,2‐dimethoxyethane) as well aliphatic reaction media (toluene n ‐heptane) display superior activity highly lipophilic...
Abstract Two near‐infrared (NIR) emissive π ‐conjugated covalent organic frameworks (COFs) pTANG1 and pTANG2 are synthesized using Knoevenagel condensation of trioxaazatriangulenetricarbaldehyde (TATANG) with benzene‐ biphenyldiacetonitriles, respectively. The morphology the COFs is affected by size TATANG precursor crystals. Donor–acceptor interactions in these result small bandgaps (≈1.6 eV) NIR emission (λ max = 789 nm for pTANG1). can absorb up to 9 molecules water per unit cell, which...
Abstract Two‐dimensional (2D) assemblies of water‐soluble block copolymers have been limited by a dearth systematic studies that relate polymer structure to pathway mechanism and supramolecular morphology. Here, we employ sequence‐defined triblock DNA amphiphiles for the polymerization free‐standing nanosheets in water. Our modulation amphiphile sequence shows alkyl chain core forming cell membrane‐like distal π‐stacking chromophore folding back interact with hydrophilic on nanosheet...
The self-assembly of block copolymers is often rationalized by structure and microphase separation; pathways that diverge from this parameter space may provide new mechanisms polymer self-assembly. Here, we show the sequence length single-stranded DNA directly influence sequence-defined copolymers. While increasing led to predictable changes in self-assembly, changing only produced three distinct structures: spherical micelles (spherical nucleic acids, SNAs) flexible poly(thymine) DNA,...