A5041362157- Advanced biosensing and bioanalysis techniques
- DNA and Nucleic Acid Chemistry
- RNA Interference and Gene Delivery
- Iron oxide chemistry and applications
- Supramolecular Self-Assembly in Materials
- Nanopore and Nanochannel Transport Studies
- Metal Extraction and Bioleaching
- Polydiacetylene-based materials and applications
- Nanowire Synthesis and Applications
- RNA and protein synthesis mechanisms
- Biosensors and Analytical Detection
- Nanofabrication and Lithography Techniques
- Iron Metabolism and Disorders
- Molecular Junctions and Nanostructures
- Ion-surface interactions and analysis
- Gold and Silver Nanoparticles Synthesis and Applications
- DNA and Biological Computing
- Folate and B Vitamins Research
- Fuel Cells and Related Materials
- Bacteriophages and microbial interactions
- Mine drainage and remediation techniques
University of Cambridge
2022-2025
McGill University
2016-2024
University of Calgary
2016-2020
Abstract Biopolymers such as nucleic acids and proteins exhibit dynamic backbone folding, wherein site-specific intramolecular interactions determine overall structure. Proteins then hierarchically assemble into supramolecular polymers microtubules, that are robust yet dynamic, constantly growing or shortening to adjust cellular needs. The combination of energy-driven folding growth with structural stiffness length control is difficult achieve in synthetic polymer self-assembly. Here we show...
RNA is the key biomolecule in innumerable diagnostic and therapeutic applications, but its chemical instability plagues researchers clinicians alike. Gel electrophoresis remains predominant method for assessment of degradation: The main drawback quantity required - typically 100 ng or more. To study degradation profiles mRNA vaccines, viral bacterial RNA, other valuable species, new sensitive quantitative methodologies are required. We present use solid-state nanopore sensing to evaluate...
Nanopore analysis relies on ensemble averaging of translocation signals obtained from numerous molecules, requiring a relatively high sample concentration and long turnaround time the to results. The recapture subsequent re-reading same molecule is promising alternative that enriches signal information single molecule. Here, we describe how an asymmetric nanopore improves molecular ping-pong by promoting in trans reservoir. We also demonstrate could be improved linking target DNA carrier...
RNA is a key biochemical marker, yet its chemical instability and complex secondary structure hamper integration into DNA nanotechnology-based sensing platforms. Relying on the denaturation of native using urea, we show that restructured DNA/RNA hybrids can readily be prepared at room temperature. Using solid-state nanopore sensing, demonstrate structures our conform to design single-molecule level. Employing this annealing procedure, mitigate self-cleavage, enabling direct detection...
DNA nanotechnology has revolutionized the ability to position matter at nanoscale, but preparation of DNA-based architectures remains laborious. To facilitate formation custom structures, a fully automated method is reported produce sequence- and size-defined nanotubes. By programming sequential addition desired building blocks, rigid DX-tile-based nanotubes flexible wireframe structures are attained, where total number possible constructs increases as power function different units...
Dynamic wireframe DNA structures have gained significant attention in recent years, with research aimed toward using these architectures for sensing and encapsulation applications. For assemblies to reach their full potential, however, knowledge of the rates strand displacement hybridization on constructs is required. Herein, we report use single-molecule fluorescence methodologies observe reversible switching between double- single-stranded forms triangular nanotubes. Specifically, by...
RNA is a key biochemical marker yet its chemical instability and complex secondary structure hamper integration into DNA nanotechnology-based sensing platforms. Relying on the denaturation of native using urea, we show that restructured DNA/RNA hybrids can readily be prepared at room temperature. Using solid-state na-nopore sensing, demonstrate structures our conform to design single-molecule level. Employing this annealing procedure, mitigate self-cleavage, enabling direct detection...
Studies have shown that poly(adenine) DNA and RNA strands protonate at a low pH to form self-associating duplexes; however, the nanoscopic morphology of these structures is unclear. Here, we use Transition Electron Microscopy (TEM), Atomic Force (AFM), dynamic light scattering (DLS), fluorescence spectroscopy show both ribose identity (DNA or RNA) assembly conditions (thermal room-temperature annealing) dictate unique hierarchical for sequences pH. We while thermodynamic product protonating...
Abstract We present the use of maltol (3‐hydroxy‐2‐methyl‐4H‐pyran‐4‐one) as a capping ligand for iron oxide nanomaterials. Water‐soluble maltol‐coated Fe 3 O 4 nanoparticles were synthesized by reductive one‐pot synthesis. The found to be stable in water, and their superparamagnetic properties enabled application ultrahigh field T 2 magnetic resonance imaging (MRI) contrast agents. High r relaxivity / 1 ratios determined at clinical ( B 0 = T) 9.4 fields, making them on par or superior...
We report a novel process to selectively pattern nanomaterials, specifically gold nanoparticles, onto silicon surface through “click” chemistry, consistently and efficiently join together small units quick simple reaction. employed the UV-initiated thiol-ene reaction, which is used in tandem with microcontact printing. Dithiol-capped nanoparticles were as printing ink grafted ene-terminated Si(100) wafers by pressing nanoparticle-impregnated poly(dimethylsiloxane) stamp, while irradiating...
ABSTRACT DNA nanotechnology has revolutionized our ability to position matter at the nanoscale, but preparation of DNA-based architectures remains laborious. To facilitate formation custom structures, we report a fully automated method produce sequence- and size-defined nanotubes. By programming sequential addition desired building blocks, rigid DX-tile-based nanotubes (and flexible wireframe structures) are attained, where total number possible constructs increases as power function...
In this work, we present a solvothermal method for the synthesis of hematite thin films on fluorine-doped tin oxide substrates. This simple uses precursor solution iron(III) 2,4-pentanedionate dissolved in ethanol with microliter-scale amount water and yields ∼500 nm thick after annealing. The synthesized were characterized using an array methods, including scanning electron microscopy, energy-dispersive X-ray spectroscopy, diffuse reflectance, powder diffraction. Incorporating into provides...
<div>In this work, we present a solvothermal method for the synthesis of hematite thin films on fluorine-doped tin oxide</div><div>substrates. This simple uses precursor solution iron(III) 2,4-pentanedionate dissolved in ethanol with a</div><div>microliter-scale amount water and yields ~ 500-nm thick after annealing. The synthesised films</div><div>were characterised using an array methods, including scanning electron microscopy, energy-dispersive...
In this work, we present a solvothermal method for the synthesis of hematite thin films on fluorine-doped tin oxidesubstrates. This simple uses precursor solution iron(III) 2,4-pentanedionate dissolved in ethanol with amicroliter-scale amount water and yields ~ 500-nm thick after annealing. The synthesised filmswere characterised using an array methods, including scanning electron microscopy, energy-dispersive X-ray spectroscopy, diffuse reflectance, powder x-ray diffraction. Incorporating...