Abstract Deoxyribonucleic acid (DNA) hydrogels are a unique class of programmable, biocompatible materials able to respond complex stimuli, making them valuable in drug delivery, analyte detection, cell growth, and shape‐memory materials. However, unmodified DNA the literature very soft, rarely reaching storage modulus 10 3 Pa, they lack functionality, limiting their applications. Here, DNA/small‐molecule motif create stiff from DNA, 5 Pa is used. The consists an interaction between...

Nucleases present a formidable barrier to the application of nucleic acids in biology, significantly reducing lifetime acid-based drugs. Here, we develop novel methodology protect DNA and RNA from nucleases by reconfiguring their supramolecular structure through addition nucleobase mimic, cyanuric acid. In presence acid, polyadenine strands assemble into triple helical fibers known as polyA/CA motif. We report that this motif is exceptionally resistant nucleases, with constituent surviving...

The AGLO strategy generates complex gold nanostructures with user-designed morphologies in solution, using only a simple 2D DNA origami sheet as versatile transient template. products are robust and stable standalone nanostructures.

Discrete self-assembly of two Re(I) squares was achieved by a simple and efficient strategy where the complexes, [Re(4-pytpy-κ(2)N)(CO)3Br] [Re(4-pytpy-κ(3)N)(CO)2Br], act as their own ligands. The photophysical electrochemical properties assemblies precursors are described along with solid-state X-ray diffraction studies.

Nucleobase mimicking small molecules able to reconfigure DNA are a recently discovered strategy that promises extend the structural and functional diversity of nucleic acids. However, only simple, unfunctionalized such as cyanuric acid melamine have so far been used in this approach. In work, we show addition substituted can successfully program polyadenine strands assemble into supramolecular fibers. Unlike conventional nanostructure functionalization, which typically end-labels strands,...

Supramolecular materials have been assembled using a wide range of interactions, including the hydrophobic effect, DNA base-pairing, and hydrogen bonding. Specifically, amphiphiles with building block self-assemble into diverse morphologies depending on length composition both blocks. Herein, we take advantage orthogonality different supramolecular interactions - Watson-Crick-Franklin base pairing RNA kissing loops to create hierarchical self-assemblies controlled nanometer micrometer...

The double crossover junction (DX) is a fundamental building block for generating complex and varied structures from DNA. However, its implementation in functional devices limited to the inherent properties of DNA itself. Here, we developed design strategies generate first metal-DX tiles (DXM ) by site-specifically functionalizing tile crossovers with tetrahedral binding pockets that coordinate CuI . These DX junctions bind two ions independently at distinct sites, display greater thermal...

DNA tweezers have emerged as powerful devices for a wide range of biochemical and sensing applications; however, most consist single units activated by recognition, limiting their motion ability to respond complex stimuli. Herein, we present an extended, tripodal nanotweezer with small molecule junction. Simultaneous, asymmetric elongation our molecular core is achieved using polymerase chain reaction (PCR) produce length- sequence-specific arms repeating regions. When rigidified, tweezer...

We present a new strategy to achieve chiral induction and redox switching along the backbone of metallohelicate architectures, wherein DNA duplex directs handedness charge transport properties metal–organic assembly more than 60 bonds away (a distance >10 nm).

A simple one-pot procedure is described for the synthesis and purification of 4′-substituted 4,4′′-di-<i>tert</i>-butyl-2,2′:6′,2′′-terpyridine ligands. The new series ligand display improved solubility in most organic solvents comparison to traditional 2,2′:6′,2′′-terpyridine

Supramolecular chemistry involves the noncovalent assembly of monomers into materials with unique properties and wide-ranging applications. Thermal analysis is a key analytical tool in this field, as it provides quantitative thermodynamic information on both structural stability nature underlying molecular interactions. However, there exist many supramolecular systems whose kinetics are so slow that methods currently applied unreliable or fail completely. We have developed simple rapid...

Abstract The lung is a primary target for many lethal respiratory viruses, leading to significant global mortality. Current organoid models fail completely mimic the cellular diversity and intricate tubular branching structures of human lung. Lung organoids derived from adult cells have so far only included input cell region, proximal or distal. Existing are expensive. They often require invasive deep tissue biopsies. present study aimed address these limitations. obtained using an original...

Abstract The double crossover junction (DX) is a fundamental building block for generating complex and varied structures from DNA. However, its implementation in functional devices limited to the inherent properties of DNA itself. Here, we developed design strategies generate first metal–DX tiles (DX M ) by site‐specifically functionalizing tile crossovers with tetrahedral binding pockets that coordinate Cu I . These DX junctions bind two ions independently at distinct sites, display greater...

Supramolecular chemistry involves the non-covalent assembly of monomers into materials with unique properties and wide-ranging applications. Thermal analysis is a key analytical tool in this field, as it provides quantitative thermodynamic information on both structural stability nature underlying molecular interactions. However there exist many supramolecular systems whose kinetics are so slow under conditions approaching equilibrium that data inaccessible. We have developed simple rapid...

Supramolecular chemistry involves the non-covalent assembly of monomers into materials with unique properties and wide-ranging applications. Thermal analysis is a key analytical tool in this field, as it provides quantitative thermodynamic information on both structural stability nature underlying molecular interactions. However there exist many supramolecular systems whose kinetics are so slow under conditions approaching equilibrium that data inaccessible. We have developed simple rapid...

Supramolecular chemistry involves the non-covalent assembly of monomers into materials with unique properties and wide-ranging applications. Thermal analysis is a key analytical tool in this field, as it provides quantitative thermodynamic information on both structural stability nature underlying molecular interactions. However there exist many supramolecular systems whose kinetics are so slow under conditions approaching equilibrium that data inaccessible. We have developed simple rapid...

Supramolecular chemistry involves the non-covalent assembly of monomers into materials with unique properties and wide-ranging applications. Thermal analysis is a key analytical tool in this field, as it provides quantitative thermodynamic information on both structural stability nature underlying molecular interactions. However there exist many supramolecular systems whose kinetics are so slow under conditions approaching equilibrium that data inaccessible. We have developed simple rapid...