The traditional Chinese medicines (TCMs) are essential components of alternative medicines. Many TCMs known to alter the expression hepatic drug-metabolizing enzymes and transporters. molecular mechanism by which and/or their constituents regulate enzyme transporter expression, however, has remained largely unknown. In this report, we show that two TCMs, Wu Wei Zi (<i>Schisandra chinensis Baill</i>) Gan Cao (<i>Glycyrrhiza uralensis Fisch</i>), selected activate xenobiotic orphan nuclear...

Abstract Background Corneal transplantation is a common surgical intervention for restoring vision loss due to corneal damages. However, cultural reasons, there huge shortage of donor corneas in China. Acellular porcine stromas (APCSs) can be used as substitutes lamellar keratoplasty ulcers. This study was conducted analyze the results APCS use herpes simplex keratitis (HSK). Methods The involved HSK patients who underwent with APCSs from February 2016 October 2017 second affiliated hospital...

This paper addresses the non-fragile H∞-consensus control problem for multi-agent systems subject to deception attacks and missing measurements based on designed observers. First of all, a sequence Bernoulli distributed stochastic variables is applied characterise random nature measurements, where changeable probability constrained by norm-bounded condition reflect reality more closely. Next, constraint conditions are given malicious signal considered in with purpose limiting difference...

Angelica sinensis (Oliv.) Diels (DG), Ligusticum chuanxiong Hort. (CX) and Rheum palmatum L. (DH), three well known traditional Chinese medicines (TCM), have been used widely for the treatment of various types disorders in China. Herb–drug interactions, especially cytochrome P450 (CYP)-mediated cause an enhancement or attenuation efficacy co-administered drugs. In this study, to assess possible interactions between TCM drugs, effect water ethanol extracts DG, CX DH on were studied rats. The...

Abstract Rhein, an active ingredient extensively found in plants such as Aloe, Cassitora L., rhubarb and so on, has been used for a long time China. Pharmacological tests revealed that rhein not only had strong antibacterial action, but also may be useful cancer chemotherapy biochemical modulator. Its therapeutic action toxicity is still the subject of considerable research. With microsome incubation assays vitro HPLC methods, inhibition rat liver CYP1A2, CYP2C9, CYP2D6, CYP2E1 CYP3A enzymes...

Background: Cognitive deficits and behavioral disorders such as anxiety depression are common manifestations of Alzheimer’s disease (AD). Our previous work demonstrated that Trichostatin A (TSA) could alleviate neuroinflammatory plaques improve cognitive disorders. AD, anxiety, all associated with microglial inflammation. However, whether TSA attenuate anxiety- depression-like behaviors in APP/PS1 mice through anti-inflammatory signaling is still unclearly. Methods: In the present study,...

Abstract Despite advances in therapies, glioblastoma (GBM) recurrence is almost inevitable due to the aggressive growth behavior of GBM cells and drug resistance. Temozolomide (TMZ) preferred for chemotherapy, however, development TMZ resistance over 50% cases patients. To investigate mechanism invasive characteristics GBM, analysis combined RNA-seq ChIP-seq was performed response treatment. We found that PERK/eIF2α/ATF4 signaling significantly upregulated with treatment, while blockage ATF4...

Abstract Drug–drug interaction potentials of an herbal medicine named Glycyrrhiza uralensis was investigated in rats via vitro and vivo pharmacokinetic studies. P 450 levels the metabolic rate lidocaine liver microsomes prepared from different treatment groups were measured. In a separate study, parameters plasma urine estimated. pretreated by significant higher than that non‐treatment control. The increase dose‐dependent. (1 3 g/kg) increased 62% 91%, respectively, compared with control...

We report a quantitative SERS measurement scheme based on the magnetic microsphere–Ag nanoparticles to detect target DNA.

As a kind of versatility cytokines, overexpression macrophage migration inhibitory factor (MIF) and vascular endothelial growth factor-C (VEGF-C) have been reported in wide variety tumors. However, the correlation mechanism between MIF VEGF-C are still not clear. an important signal transduction system, MAPK signaling pathways participate biological behavior cells. The purposes this study to relationship discuss role pathway relationship. In study, we first knocked down using small...

This paper presents a new ray tracing method, which contains whole set of mathematic models, and its validity is verified by simulations. In addition, both theoretical analysis simulation results show that the computational complexity method much lower than previous ones. Therefore, can be used to rapidly calculate impulse response wireless optical channels for complicated systems.

A topological photonic crystal InGaAsP/InP core-shell nanowire array laser with bulk states operating in the 1550 nm band is proposed and simulated. By optimizing structure parameters, high Q factor of 1.2 × 10

Abstract Molecular beacon is a promising tool for mRNA detection in living cells. But the low detecting efficiency and narrow application range limited its development. In this study, we synthesized novel gold nanoparticle (AuNP) by optimizing sequence amount modified polyethylene glycol (PEG) cell‐penetrating peptide (CPP) on core. Then, mechanism of cell uptake was investigated. Lastly, used AuNP to study Akt‐mTOR‐HIF‐1 signaling pathway function miR‐7 breast tumor The results showed that...

The Jiangmen Underground Neutrino Observatory (JUNO) is a 20 kton multi-purpose liquid scintillator detector with an expected $3\%/\sqrt{E[\mbox{Mev}]}$ energy resolution, under construction in 700 m underground laboratory the south of China (Jiangmen city, Guangdong province). exceptional resolution and massive fiducial volume JUNO offer great opportunities for addressing many essential topics neutrino astroparticle physics. JUNO's primary goals are to determine mass ordering precisely...

Measuring the neutrino mixing parameter \ensuremath{\sin^2\theta_{13}} to sub-percent precision level could be necessary in next ten years for unitary test of PMNS matrix. In this work, we discuss possibility such a measurement with reactor antineutrinos. We find that single liquid scintillator detector on reasonable scale achieve goal. propose install $\sim10$\% energy resolution at about 2.0~km from reactors JUNO-like overburden. The integrated luminosity requirement is 150~${\rm...

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Blending co-combustion fuel is an effective strategy for improving the low combustion performance of ammonia (NH3), enabling its use as a power fuel. In this study, impact and underlying reasons types blending ratios low-carbon alkanes (methane ethane, C1/C2) on NH3 were elucidated at level chemical reaction mechanisms efficacy reactive radicals, through experimental numerical simulation approaches. Using dimethyl ether reference to estimate energy efficiency supply. The research indicates...