A5058853456- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
- Organ Donation and Transplantation
- DNA Repair Mechanisms
- Organ Transplantation Techniques and Outcomes
- Lung Cancer Research Studies
- Tissue Engineering and Regenerative Medicine
- Mesenchymal stem cell research
- COVID-19 and Mental Health
- COVID-19 Clinical Research Studies
- Genetics and Neurodevelopmental Disorders
- Long-Term Effects of COVID-19
- Hepatitis B Virus Studies
- Renal Transplantation Outcomes and Treatments
- Bladder and Urothelial Cancer Treatments
- Acne and Rosacea Treatments and Effects
- HIV Research and Treatment
- Dermatologic Treatments and Research
- Acute Lymphoblastic Leukemia research
- Hair Growth and Disorders
- Epilepsy research and treatment
- Cancer-related gene regulation
- Genomic variations and chromosomal abnormalities
- Healthcare professionals’ stress and burnout
Mashhad University of Medical Sciences
2025
Shiraz University of Medical Sciences
1995-2024
Hamedan University of Medical Sciences
2024
Shahid Beheshti University of Medical Sciences
2023-2024
Shahid Sadoughi University of Medical Sciences and Health Services
2023
Lake Washington Institute of Technology
2021
Bellevue Hospital Center
2020
Claritas Genomics (United States)
2016-2018
National Institute of Genetic Engineering and Biotechnology
2010-2016
Harvard University
2016
Abstract Background This study aimed to compare anthropometric indices predict type 2 diabetes mellitus (T2DM) among first-degree relatives of diabetic patients in the Iranian community. Methods In this study, information on 3483 (FDRs) was extracted from database Endocrinology and Metabolism Research Center Isfahan University Medical Sciences. Overall, 2082 FDRs were included analyses. A logistic regression model used evaluate association between odds having diabetes. Furthermore, a...
Genomic instability drives tumorigenesis, but how it is initiated in sporadic neoplasias unknown. In early preneoplasias, alterations at chromosome fragile sites arise due to DNA replication stress. A frequent, perhaps earliest, genetic alteration preneoplasias deletion within the FRA3B/FHIT locus, leading loss of Fhit protein expression. Because common are exquisitely sensitive stress, has been proposed that their clonal cancer cells stress sensitivity rather than a selective advantage...
Chromosomal positions of common fragile sites differ in lymphoblasts and fibroblasts, with dependent on the epigenetically determined density replication origins at these loci. Because rearrangement loci associated loss gene products are hallmarks cancers, we aimed to map epithelial cells, from which most cancers derive. Among five frequently activated human cells were chromosome bands 2q33 Xq22.1, not among top identified or fibroblasts. FRA16D 16q23 was three examined, as it is while FRA3B...
Background Coronavirus disease 2019 (COVID‐19) typically presents with respiratory illness ranging in severity. Neurological complications of the remain largely unknown. Herein, we discuss case a woman diagnosed COVID‐19 meningitis following two positive cerebrospinal fluid (CSF) RT‐PCR assays, and highlight importance recognizing neurological manifestations disease. Case report The patient was 49‐year‐old history hypertension who presented non‐specific symptoms (fever, headache, malaise,...
Abstract Background Besides the lungs, coronavirus disease 2019 (COVID-19) can affect cardiovascular, digestive, urinary, hepatic, and central nervous systems. Other than its short-term effects, COVID-19 may also cause long-term complications. In this study, we assessed cardiovascular symptoms among patients in a clinic. Method A retrospective cohort was conducted between October 2020 to May 2021 on at an outpatient clinic Shiraz, Iran. Patients with history of least one year before their...
Aberrant methylation of the promoter CpG island human genes is an alternative gene inactivation mechanisms that contributes to carcinogenesis tumors. We tried determine status and its impact on expression two tumor related Casp-8 Rb1 in 103 bladder tissues 48 control paraffin-embedded by using MSP-PCR SQRT-PCR. Of patients, 19.4% for 28.2% showed cancer. There were significant differences between patients healthy controls (p = 0.001) 0.008) especially when both methylated 0.004). Methylation...
Interleukin-12 (IL-12) as an antitumor and interleukin-6 (IL-6) inflammatory cytokine, are immunomodulatory products that play important roles in responses cancers inflammation. We tested the association between two polymorphisms of IL-12(1188A>C; rs3212227) IL-6 (-174 C>G) risk bladder cancer 261 patients 251 healthy individuals. also investigated possible these SNPs with high-risk jobs smoking habits incidence cancer. The genotype distributions C/G) were similar cases control groups;...
Abstract Background Mesenchymal stromal cell (MSC) transplantation can improve the left ventricular ejection fraction (LVEF) after an acute myocardial infarction (AMI). Transplanted MSCs exert a paracrine effect, which might be augmented if repeated doses are administered. This study aimed to compare effects of single versus double Wharton’s jelly (WJ-MSCs) on LVEF post-AMI. Methods We conducted single-blind, randomized, multicenter trial. After 3–7 days AMI treated successfully by primary...
Introduction. Takotsubo cardiomyopathy (TCM) features transient left ventricular apical dysfunction or ballooning. The underlying mechanism remains elusive; however, evidence suggests the role of different physical and psychological stressors. We systematically reviewed patients presenting with TCM autoimmunity to explore link between two conditions. Methods. applied Preferred Reporting Items for Systematic reviews Meta-Analyses extension Scoping Reviews (PRISMA-ScR) report this review....
Most patients (70%) with limited-stage SCLC (LS-SCLC) who are treated curative-intent therapy suffer disease relapse and cancer-related death. We evaluated circulating tumor DNA (ctDNA) as a predictor of death after definitive in LS-SCLC.In our previous work, we developed plasma-based ctDNA assay to sequence 14 genes (TP53, RB1, BRAF, KIT, NOTCH1-4, PIK3CA, PTEN, FGFR1, MYC, MYCL1, MYCN) that frequently mutated SCLC. In this 177 plasma samples from 23 LS-SCLC completed chemoradiation (n =...
For the present study, two polymorphisms, xeroderma pigmentosum, complementation group D (XPD) Lys751Gln and RAD51 135G/C were studied with regard to bladder cancer. XPD polymorphism, an increased risk of cancer was found be associated Gln variant allele (odds ratio [OR]=1.86, 95% confidence interval [CI]=1.27-2.73), on taking AA (Lys/Lys) as referent genotype. In males, 751C (Gln) a significantly (OR=2.33, CI=1.52-3.56). The inhabitants rural areas showed (OR=2.59, CI=1.46-4.62) when...
Background: The coronavirus disease 2019 (COVID-19) pandemic is a critical world concern, with healthcare workers (HCWs) at high risk of infection. Thus, sufficient level knowledge, attitude, and practice (KAP) must be ensured. Objectives: We aimed to investigate the KAP toward COVID-19 among HCWs in Shiraz, Iran. Methods: A cross-sectional study was performed on large sample dealing multiple hospitals affiliated Shiraz University Medical Sciences. survey featured four sections: demographic...