A5047928511- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Molecular Junctions and Nanostructures
- Venous Thromboembolism Diagnosis and Management
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging and Pathology Studies
- Medical Imaging Techniques and Applications
- Porphyrin and Phthalocyanine Chemistry
- Radiation Dose and Imaging
- Electrochemical Analysis and Applications
- Central Venous Catheters and Hemodialysis
- Renal cell carcinoma treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Organic Electronics and Photovoltaics
- Diagnosis and Treatment of Venous Diseases
- Photochromic and Fluorescence Chemistry
- Pleural and Pulmonary Diseases
- Radiology practices and education
- Metabolomics and Mass Spectrometry Studies
- RNA modifications and cancer
- Graphene research and applications
- Liver Disease Diagnosis and Treatment
- Ultrasound in Clinical Applications
King's College London
2024
Rajiv Gandhi University
2024
Exact Sciences (United States)
2024
Agilent Technologies (United States)
2023
University of Colorado Denver
2012-2021
Weizmann Institute of Science
2018-2020
Bellevue Hospital Center
2017-2020
Indian Institute of Science Bangalore
2017-2019
The Medical Center of Aurora
2018
University of Colorado Boulder
2018
The National Lung Screening Trial (NLST) is a randomized multicenter study comparing low-dose helical computed tomography (CT) with chest radiography in the screening of older current and former heavy smokers for early detection lung cancer, which leading cause cancer-related death United States. Five-year survival rates approach 70% surgical resection stage IA disease; however, more than 75% individuals have incurable locally advanced or metastatic disease, latter having 5-year less 5%. It...
Clinical trials of the KRAS inhibitors adagrasib and sotorasib have shown promising activity in cancers harboring glycine-to-cysteine amino acid substitutions at codon 12 (KRAS
Purpose To determine the prevalence of interstitial lung abnormalities (ILAs) at initial computed tomography (CT) examination and rate progression ILAs on 2-year follow-up CT images in a National Lung Screening Trial population studied single site. Materials Methods The study was approved by institutional review board informed consent obtained from all participants. Image for this HIPAA compliant. We reviewed 884 cigarette smokers who underwent low-dose site Trial. findings were categorized...
Despite initial effectiveness of ALK receptor tyrosine kinase inhibitors (TKIs) in patients with ALK+ NSCLC, therapeutic resistance will ultimately develop. Serial tracking genetic alterations detected circulating tumor DNA (ctDNA) can be an informative strategy to identify response and resistance. This study evaluated the utility analyzing ctDNA as a function ensartinib, potent second-generation TKI.Pre-treatment plasma was collected from 76 NSCLC who were TKI-naive or had received prior...
PURPOSE: To compare the accuracy of spiral computed tomography (CT) with that ventilation-perfusion (V-P) scintigraphy in diagnosis pulmonary embolism (PE). MATERIALS AND METHODS: Fifty-four patients whom indeterminate V-P scans or discordant clinical and scintigraphic results were obtained underwent both scanning contrast material-enhanced CT. The reference standard was angiographic 26 (group I) outcome 28 II). RESULTS: Six (25%) 24 group I had proved PE. prospective sensitivity specificity...
Liquid biopsy for plasma circulating tumor DNA (ctDNA) next-generation sequencing (NGS) is commercially available and increasingly adopted in clinical practice despite a paucity of prospective data to support its use.Patients with advanced lung cancers who had no known oncogenic driver or developed resistance current targeted therapy (n = 210) underwent NGS, targeting 21 genes. A subset patients concurrent tissue NGS testing using 468-gene panel 106). Oncogenic detection, test turnaround...
Clinical validity of helical CT being interpreted as negative for pulmonary embolism: implications patient treatment.K Garg, H Sieler, C Welsh, R J Johnston and P D RussAudio Available | Share
OBJECTIVE. The purpose of this study was to compare combined CT pulmonary angiography and venography with leg sonography for accuracy relative efficacy in diagnosis deep venous thrombosis from the popliteal vein common femoral vein.
To evaluate agreement among radiologists on the interpretation of pulmonary findings at low-dose computed tomographic (CT) screening examinations for lung cancer.Institutional review board approval and informed consent were obtained. HIPAA guidelines followed. Sixteen from 10 National Lung Screening Trial centers Cancer Institute's Study network reviewed image subsets 135 baseline CT in trial participants (89 men, 46 women; mean age, 62.7 years +/- 5.4 [standard deviation]). Interpretations...
Multi-heme cytochromes (MHCs) are fascinating proteins used by bacterial organisms to shuttle electrons within, between, and out of their cells. When placed in solid-state electronic junctions, MHCs support temperature-independent currents over several nanometers that 3 orders magnitude higher compared other redox similar size. To gain molecular-level insight into astonishingly high conductivities, we combine experimental photoemission spectroscopy with DFT+Σ current–voltage calculations on...
One of the challenges for realization molecular electronics is design nanoscale wires displaying long-range charge transport. Graphene nanoribbons are an attractive platform development with conductance owing to their unique electrical properties. Despite potential, transport properties single remain underexplored. Herein, we report a synthetic approach prepare N-doped pyrene-pyrazinoquinoxaline graphene terminated diamino anchoring groups at each end. These terminal allow formation stable...
Cancer-associated venous thromboembolism (VTE) is a major source of oncologic cost, morbidity and mortality. Identifying high-risk patients for prophylactic anticoagulation challenging adds to clinician burden. Circulating tumor DNA (ctDNA) sequencing assays ('liquid biopsies') are widely implemented, but their utility VTE prognostication unknown. Here we analyzed three plasma cohorts: pan-cancer discovery cohort 4,141 with non-small cell lung cancer (NSCLC) or breast, pancreatic other...
To measure reader agreement in determining whether lung nodules detected at baseline screening computed tomography (CT) had changed subsequent examinations and to evaluate the variability recommendations for further follow-up.
Rationale: Screening for lung cancer using low-dose computed tomography (CT) reduces mortality. However, in addition to a high rate of benign nodules, screening detects large number indolent cancers that generally belong the adenocarcinoma spectrum. Individualized management screen-detected adenocarcinomas would be facilitated by noninvasive risk stratification.Objectives: To validate Computer-Aided Nodule Assessment and Risk Yield (CANARY), novel image analysis software, successfully...
We study solvent-free electron transport across two multi-heme cytochrome c-type proteins, MtrF and STC, find that they are better at conducting than non- or mono heme proteins.
To assess the feasibility of conducting a randomized controlled trial for lung cancer screening.Subjects are being recruited into to undergo either low-dose spiral computed tomography (CT) or observation. Subjects from high-risk group with known chronic obstructive pulmonary disease and sputum atypia moderate-risk randomly selected general population Veterans Affairs Medical Center. All subjects must be 50-80 years age 30 more pack-years cigarette smoking not have undergone chest CT during...