A5064010392- Microbial Natural Products and Biosynthesis
- Plant biochemistry and biosynthesis
- Natural product bioactivities and synthesis
- Fungal Biology and Applications
- Traditional Chinese Medicine Analysis
- Marine Sponges and Natural Products
- Genomics and Phylogenetic Studies
- Alkaloids: synthesis and pharmacology
- Chemical synthesis and alkaloids
- Sesquiterpenes and Asteraceae Studies
- Microbial Metabolism and Applications
- Chromatography in Natural Products
- Tuberculosis Research and Epidemiology
- Drug-Induced Hepatotoxicity and Protection
- Berberine and alkaloids research
- Enzyme Catalysis and Immobilization
- Viral gastroenteritis research and epidemiology
- Ion channel regulation and function
- Clostridium difficile and Clostridium perfringens research
- Synthesis of β-Lactam Compounds
- Traditional and Medicinal Uses of Annonaceae
- Autoimmune and Inflammatory Disorders Research
- Studies on Chitinases and Chitosanases
- Insect symbiosis and bacterial influences
- Mycorrhizal Fungi and Plant Interactions
Griffith University
2020-2025
The University of Queensland
2024-2025
Guangdong University of Technology
2024
Institute of Microbiology
2014-2021
Chinese Academy of Sciences
2014-2021
University of Chinese Academy of Sciences
2016-2019
China Institute of Daily Chemical Industry
2012
Yuhan University
1999
Laboratoire de Génétique Médicale
1995
Laboratory of Molecular Genetics
1995
The chromosomal location of SCN5A, the gene encoding principal voltage-gated Na<sup>+</sup> channel expressed in human heart, has been determined by three independent methodologies: somatic cell hybrid mapping, micro-dissection-polymerase chain reaction, and fluorescence situ hybridization. SCN5A was assigned to short arm chromosome 3 (band 3p21) all approaches. These data are further evidence that striated muscle genes dispersed genome.
Background: The increasing prevalence of drug-resistant tuberculosis (TB) underscores the urgent need for novel antimicrobial agents. Methods: This study integrates cultivation optimization, nuclear magnetic resonance (NMR) fingerprinting, and principal component analysis (PCA) to explore microbial secondary metabolites as potential anti-TB Results: Using combined approach, 11 bioactive compounds were isolated identified, all exhibiting anti-Mycobacterium bovis BCG activity. Notable findings...
The marine-derived fungus Aspergillus fumigatus MF071, isolated from sediment collected the Bohai Sea, China, yielded two new compounds 19S,20-epoxy-18-oxotryprostatin A (1) and 20-hydroxy-18-oxotryprostatin (2), in addition to 28 known (3–30). chemical structures were established on basis of 1D, 2D NMR HRESIMS spectroscopic data. This is first report data monomethylsulochrin-4-sulphate (4) pseurotin H (10) as naturally occurring compounds. Compounds 15, 16, 20, 23, 30 displayed weak...
The growing number of sequenced microbial genomes has revealed a remarkably large secondary metabolite biosynthetic clusters for which the compounds are still unknown. aim present work was to apply strategy detect newly induced natural products by cultivating microorganisms in different fermentation conditions. metabolomic analysis 4160 fractions generated from 13 actinomycetes under 32 culture conditions carried out 1H NMR spectroscopy and multivariate analysis. principal component (PCA)...
Elucidation of the mechanism action compounds with cellular bioactivity is important for progressing into future drug development. In recent years, phenotype-based discovery has become dominant approach to over target-based discovery, which relies on knowledge a specific target disease. Still, when targeting an infectious disease via high throughput phenotypic assay it highly advantageous identifying compound’s activity. A fraction derived from plant Polyalthia sp. showed activity against...
A chemical investigation of the Australian pasture soil-derived Actinomadura sp. S4S-00245B09, supported by chemical, bioactivity and cultivation profiling, yielded a new class terpenyl-quinolin-4(1H)-ones, goondolinones B (1 2), featuring an unprecedented fused seven-membered ether. Structures were assigned to 1 2 on basis detailed spectroscopic analysis, including X-ray analysis 1, biosynthetic considerations. Goondolinone (1) lacks antibacterial or antifungal properties, is noncytotoxic...
Four new alkaloids, (R)-nomimantharine trifluoroacetate (2), 12-demethylphaeantharine (3), nominanthranal (4), and the enolic form of 1-hydroxy-6,7-dimethoxy-2-methylisoquinoline (5), together with known dimeric alkaloid phaeantharine (1), have been isolated from extract leaves rainforest tree Doryphora aromatica (Monimiaceae). The structures these compounds were elucidated by HRMS 1D 2D NMR data. (R)-Nomimantharine (2) contains an ether linkage connecting a benzylisoquinoline unit...
A new NMR-based method to access the unique components of drug-like natural product metabolome termite-gut associated<italic>Streptomyces strains</italic>has been developed.
A chemical investigation of Australian soil-derived bacteria
Fragment-based drug discovery (FBDD) focuses on small compounds, known as fragments, typically with a molecular weight of less than 300 Da. This study highlights the benefits employing pure natural product library for FBDD, contrasting predominant use synthetic libraries. Practical methods rapidly constructing such libraries from crude extracts were demonstrated across various plant and microbial samples. Twenty-nine (29) including new compound (20), identified. Antimicrobial activities...
A bioassay-guided chemical investigation of an Australian pasture-soil-derived Streptomyces sp. yielded the rare carbocyclic ansa-polyketide kendomycin (1) along with a series new analogues, goondomycins A–H (2–9), featuring unprecedented carbo/heterocyclic scaffolds and chromophores, structures assigned by detailed spectroscopic analysis, biochemical transformations, biosynthetic considerations. Goondomycins B (2) F (7) are noteworthy in being potent motility inhibitors heartworm...
Microbes serve as the most important resource for drug discovery. During our screening bioactive compounds from natural products library, a pathogenic fungus, Microdochium majus strain 99049, wheat was selected further investigation. A new alkaloid named brocaeloid D (1), together with six previously characterized (2-7) were identified. Compound 1 belongs to 4-oxoquinoline C-2 reversed prenylation and succinimide substructure. All structures of these newly isolated determined by different...
Two potent anti-MRSA tanshinone glycosides (1 and 2) were discovered by targeted microbial biotransformation, along with rapid identification via MS/MS networking. Serial reactions including dehydrogenation, demethylations, reduction, glycosylation methylation have been observed after incubation of IIA fungus Mucor rouxianus AS 3.3447. In addition, tanshinosides B (2) showed activities against serial clinical isolates oxacillin-resistant Staphylococcus aureus MIC values 0.78 μg/mL. This is...
Background/Objectives: There is an urgent need for new and improved anthelmintics that are not constrained by existing resistance pathways can safeguard the health welfare of animals. Methods: An integrated platform chemical, bioassay, cultivation profiling applied to a library microbes isolated from Australian livestock pasture soil was used detect guide production, isolation, characterization, identification, evaluation natural products with anthelmintic properties. Results: A global...