Abstract Cough is a protective respiratory reflex used to clear airway mucus. For patients with cough weakness, such as chronic obstructive pulmonary disease, neuromuscular weakness disease and other diseases, assisted coughing techniques are essential help them In this study, the Eulerian wall film model was applied simulate clearance process through computational fluid dynamics methodology. Airway generation 0 2 based on realistic geometry considered in study. To quantify effectiveness,...

Glioblastoma (GBM), a formidable and highly aggressive form of brain cancer, is predominantly driven by GBM stem cells (GSCs), which are characterized their ability for self-renewal aberrant differentiation. Targeting the terminal differentiation GSCs represents promising therapeutic strategy. This study aimed to elucidate role synapsin III (SYN3) in driving into neuron-like its effect on tumor-suppressive pathways GBM. Proliferation assays, limited dilution immunocytochemistry, western...

Mechanical ventilation is an effective treatment for critically ill patients and those with pulmonary diseases. However, patient-ventilator asynchrony (PVA) remains a significant challenge, potentially leading to high mortality. Improving synchrony poses complex decision-making problem in clinical practice. Traditional methods rely heavily on clinicians' experience, often resulting inefficiencies, delayed ventilator adjustments, resource shortages. This paper proposes novel approach using...

Abstract Bronchial diameter is a key parameter that affects the respiratory treatment of mechanically ventilated patients. In this paper, to reveal influence bronchial on airflow dynamics pressure‐controlled patients, new system model presented combines multigeneration airways with lungs. Furthermore, experiments and simulation studies verify are performed. Finally, through study, it can be determined in airway generations 2 7, when reduced half original value, maximum air pressure (maximum...

A cough is a respiratory reflex for mucus clearance. The airflow dynamics can be characterized by three parameters, which are peak flow rate (CPFR), velocity time (PVT), and expired volume (CEV). In this study, the three-dimensional human airways from generation 0 to 5 reconstructed computerized tomography images. non-Newtonian property of considered. airflow–mucus interaction phenomenon has been analyzed in space based on Eulerian wall film model. maximum air shear stress could reach 38 m/s...

Secretions in the airways of mechanical ventilated patients are extremely dangerous to patients' health. In recent studies, continuous constant airflow is adopted, however, it not consistent with a clinical situation. To study respiratory dynamic characteristics secretion airways, mathematical model based on ventilation established this paper. illustrate secretion's influence dynamics system, three key parameters which cross section area ratio secretion/ pipe, air-secretion contact area, and...

Mechanical ventilation is an important life support treatment of critically ill patients, and air pressure dynamics human lung affect effects. In this paper, in order to obtain the influences seven key parameters mechanical system on lung, firstly, was considered as a pure pneumatic system, then its mathematical model set up. Furthermore, verify model, prototype simulator proposed for experimental study. Last, simulation studies flow dynamic were done, characteristics obtained. The study can...

Abstract Coughing is an irritable reaction that protects the respiratory system from infection and improves mucus clearance. However, for patients who cannot cough autonomously, assisted device essential Considering low efficiency of current devices, a new simulated based on pneumatic proposed in this paper. Given uncertainty airflow rates necessary to clear airways, computational fluid dynamics Eulerian wall film model (CE) were used study simulate process evaluate effectiveness. The...

Sputum deposition blocks the airways of patients and leads to blood oxygen desaturation. Medical staff must periodically check breathing state intubated patients. This process increases workload. In this paper, we describe a system designed acquire respiratory sounds from subjects, extract audio features, classify these detect presence sputum. Our method uses 13 features extracted time-frequency spectrum sounds. To test our system, 220 sound samples were collected. Half collected with sputum...

Mechanical ventilation is an important and effective method for the treatment of pulmonary diseases patients with spontaneous breathing. Spontaneous breathing refers to physiological activity caused by respiratory muscle. These retain some ability breathe spontaneously, but do not reach level normal Mathematical simulation modeling mechanical system are crucial research on ventilation. In this paper, a novel pneumatic model considering patients' presented. equations accurately derived...

Volume controlled mechanical ventilation system is a typical time-delay system, which applied to ventilate patients who cannot breathe adequately on their own. To illustrate the influences of key parameters ventilator dynamics ventilated respiratory this paper firstly derived new mathematical model system; secondly, simulation and experimental results are compared verify model; lastly, carried out. This study can be helpful in VCV treatment diagnostics.

Cough is a respiratory protective behavior for clearing the secretion. The cough process can be characterized by three features which are peak flow rate, velocity time, and expired volume. volume (CEV) rate (CPFR) important medical diagnosis effectiveness assessment. In this study, CEV CPFR values of 700 healthy participants were measured collected using portable pulmonary function device. gender, age, height, weight, smoking status information also collected. Meanwhile, integration...

In clinic, the acquisition of airflow with nasal prongs, masks, thermistor to monitor respiratory function is more uncomfortable and inconvenience than surface diaphragm electromyography (EMGdi) using electrode pads. The EMGdi strong electrocardiograph (ECG) interference affect extraction its characteristic information. this work, signals 20 subjects were collected under 5 incremental inspiratory threshold loading protocols from quiet breathing maximum forced breathing. First, we filtered...

The COVID-19 pandemic has caused a severe global problem of ventilator shortage. Placing multiple patients on single (ventilator sharing) or dual patient ventilation been proposed and conducted to increase the cure efficiency for ventilated patients. However, ventilator-sharing method needs use same settings all patients, which cannot meet different Therefore, novel multivent system non-invasive in this study. close loop consists proportional valve flow-pressure sensor can regulate airway...

Purpose This paper aims to carry out the research on influence of ground effect performance robotic fish propelled by oscillating paired pectoral fins. Design/methodology/approach The two-dimensional model fin without considering flexible deformation is established introducing a fluid model. parameters are analyzed. Finally, test platform built, and series hydrodynamic experiments carried study propulsion fins under different motion parameters. Findings thickness trailing edge effective...

Secretions of ventilated patients must be cleared efficiently and timely; to improve the secretion clearance efficiency an insufflation-exsufflation device (IL-IE device) lay a foundation for optimization IL-IE device, mathematical model ventilation system with is set up. Through experimental simulation research on system, it can concluded that, firstly, proved authentic reliable. Secondly, deposition or increase in respiratory compliance, peak exsufflation airflow may reduced. Thirdly,...

The synchrony of patient-ventilator interaction affects the process mechanical ventilation which is clinically applied for respiratory support. occurrence asynchrony (PVA) not only increases risk ventilator complications but also comfort patients. To solve problem uncertain in system, a novel method to evaluate proposed this article. Firstly, pneumatic model established simulate verified be accurate by experiments. Then, PVA phenomena are classified and detected based on analysis waveforms....

Underwater laser communication is an efficient method used in underwater environment. It has been many instruments to achieve high speed and wide band data transmission. In the presented paper, we simulate analyze affection on transmitting caused by random particle. We use Monte carol mechanism as tool a scenario of communication. focus relationship between density different particles water transmission area. Simulation results show that output intensity under rule exponential distribution...

In order to achieve precise respiratory therapy for mechanically ventilated patients, real-time monitoring of the state parameters inhaled and exhaled gases is required. These are primarily measured by ventilators, with limitations such as insufficient parameters, circuit leaks, constraints imposed distance obstacles. This paper designs a low-power wireless sensor multi-parameter near patient, which can be used continuously approximately 60 days. Based on this sensor, an intelligent system...