A5016777285- Cutaneous lymphoproliferative disorders research
- Skin Diseases and Diabetes
- Lymphoma Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Nail Diseases and Treatments
- Dermatologic Treatments and Research
- Inflammatory Myopathies and Dermatomyositis
- Nonmelanoma Skin Cancer Studies
- Autoimmune Bullous Skin Diseases
- Vascular Malformations and Hemangiomas
- Infectious Diseases and Tuberculosis
- Psoriasis: Treatment and Pathogenesis
- Soft tissue tumors and treatment
- melanin and skin pigmentation
- Skin Protection and Aging
- Leprosy Research and Treatment
- Vascular Tumors and Angiosarcomas
- Cancer and Skin Lesions
- Tumors and Oncological Cases
- Genetic and rare skin diseases.
- Cutaneous Melanoma Detection and Management
- Mycobacterium research and diagnosis
- Urticaria and Related Conditions
- Drug-Induced Adverse Reactions
- Mast cells and histamine
Mackay Medical College
2012-2025
Mackay Memorial Hospital
2016-2025
Mackay Junior College of Medicine, Nursing and Management
2012-2025
Primary Source
2010
National Science and Technology Council
2006
Academia Sinica
2006
Taipei Medical University
2003
National Taipei University of Nursing and Health Science
2003
The anticonvulsant carbamazepine (CBZ) frequently causes cutaneous adverse drug reactions (cADRs), including maculopapular eruption (MPE), hypersensitivity syndrome (HSS), Stevens–Johnson (SJS) and toxic epidermal necrolysis (TEN). We reported that SJS/TEN caused by CBZ is strongly associated with the HLA-B*1502 gene in Han Chinese. Here, we extended our genetic study to different types of CBZ-cADRs (91 patients, 60 patients SJS/TEN, 13 18 exanthema versus 144 tolerant controls). used...
Abstract Background Cutaneous tuberculosis is especially difficult to distinguish from other granulomatous dermatoses. We used polymerase chain reaction (PCR) evaluate the incidence of cutaneous and atypical mycobacterial infection in formalin‐fixed, paraffin‐embedded tissues with unspecified inflammation negative results for acid‐fast bacilli (AFB), analyzed pattern this group patients. Methods A total 38 specimens which had been collected 36 patients fulfillled criteria described above...
Glomus tumors are rare, benign, cutaneous neoplasms that must be excised completely to prevent recurrence.To investigate factors associated with recurrence of glomus after surgery.Fifty-eight women and 17 men digital underwent surgery between 1990 2008 at our hospital. These cases were retrospectively analyzed. RESULTS Mean age diagnosis was 41.8, an average diagnostic delay 3.9 years. The tumor located on a finger in 70 (right, 29; left, 41) toe five 3; 2). recurred 13 (17%) patients....
Hydroa vacciniforme (HV) is a chronic photosensitivity disorder induced by ultraviolet radiation. vacciniforme-like lymphoma rare cutaneous T-cell occurring mainly in childhood. Recent studies have demonstrated an association between latent Epstein-Barr virus (EBV) infection and both the benign skin lymphoma. The authors report 6-year-old boy with EBV infection, HV-like eruptions, hepatitis. Histopathologic examination of biopsy specimen epidermal ballooning degeneration dense superficial...
Giant cell elastolytic granuloma, also known as annular giant granuloma or actinic is histologically characterized by elastophagocytosis. Recent studies have revealed various clinical presentations in both sun-exposed and non-sun-exposed areas.To clarify characteristics based on case series observation.We retrospectively reviewed patients who fulfilled the pathological diagnosis criteria for seen at Mackay Memorial Hospital from 2000 to 2014. Patient characteristics, presentation, duration,...
The bowenoid transformation of seborrheic keratosis (SK) has rarely been reported. purpose this study is to identify their diagnostic immunohistochemical features and association with human papillomavirus (HPV) infection. Skin biopsy specimens the phenomenon were retrieved from 2001 2010. Benign SK, Bowen disease, papulosis, squamous cell carcinoma included as controls. All stained for hematoxylin eosin, Ki-67, p21, p16, p53, cyclin D1. Polymerase chain reaction-amplified HPV DNA was...
Plaque psoriasis is a debilitating condition that significantly affects patient well-being. Limited data are available regarding the effect of and treatment on health-related quality life (HRQoL) work ability among Taiwanese patients. To document compare HRQoL, satisfaction, disability patients with current past moderate-to-severe plaque psoriasis. This was multicenter, non-interventional, cross-sectional study adult During single clinic visit, each assessed for body surface area (BSA)...
Thioredoxin-interacting protein (TXNIP), also known as Vitamin-D upregulated protein-1 (VDUP-1), interacts with thioredoxin to regulate redox responses and participates in diverse disorders including metabolic, cardiovascular, inflammatory malignant diseases. Psoriasis is characterized by chronic skin inflammation an aberrant pattern of keratinocyte differentiation. Clinically, psoriasis associated various cardiometabolic comorbidities but studies on TXNIP's biological role are limited. In...
There are discrepancies in findings on direct immunofluorescence (DIF) examinations for livedoid vasculopathy. We sought to assess the usefulness of DIF as an adjunct diagnosis Clinical data and were retrospectively collected from our laboratory database 27 patients with a histopathologic vasculopathy made between July 2002 December 2008. The patterns analyzed. Positive depositions immunoreactants found 100%. A characteristic pattern homogenous vascular deposition both superficial deep blood...
Ablative laser therapy with carbon dioxide is effective for acne scars; however, the long downtime limits its use, especially in types III and IV skin. The fractional ablative 10,600-nm system reportedly maximizes efficacy minimizes side effects. goal of this study was to evaluate safety an a single treatment session on atrophic scars Asian patients. Twenty-five patients were enrolled. fluences delivered using Deep FX mode. Comparative photographs taken VISIA complexion analysis. Physician...
Neutrophilic figurate erythema (NFE) has been rarely reported. This study aimed to identify the clinical and pathological features of NFE. We retrospectively reviewed information from diagnostic cases 2000 2013. The diagnosis NFE includes clinically annular rash, histopathologically predominant neutrophilic perivascular interstitial infiltrate in dermis without evidence vasculitis, exclusion other known specific entities. Fifteen were identified, including 11 women 4 men. age distribution...
Urticaria is a prevalent disease with substantial physical, psychological, and economic impacts. With the advent of understandings emerging evidence treatments, international guidelines for treating urticaria have been updated in recent years. In order to update 2014 edition Taiwanese Dermatological Association (TDA) consensus urticaria, total 17 dermatologists extensive experience management were invited attended TDA meetings. All specific aspects content approved by at least 75% experts...
Dear Editor, In the era of coronavirus disease 2019 (COVID-19), diverse mucocutaneous responses have emerged, linked to both active COVID-19 infection and its vaccines.[1,2] These ranged from common presentations, such as erythematous maculopapular lesions, urticaria, purpuric eruptions, rare conditions Stevens–Johnson syndrome, bullous diseases, sweet syndrome. While vaccination can manifestations, they also trigger distinct reactions. Herein, we present a case lymphomatoid reaction...
A 27‐year‐old man presented with a slow‐growing, painless mass on the right anterior forearm of 4 years’ duration. Because apparent rapid enlargement mass, he underwent surgical excision in local clinic without histopathologic examination June 1999. Recurrence tumor was noted August 1999, when an excisional biopsy performed. The pathologic diagnosis giant cell tendon sheath. In December to our dermatology recurrence at same site. He denied any history trauma or particular event preceding...
Abstract: Verruciform xanthoma is xanthomatous dermal infiltrate in a proliferating epidermal lesion and an uncommon phenomenon. It has been reported various neoplastic or inflammatory conditions. We report 72‐year‐old man who had asymptomatic 1‐cm black nodule on his abdomen. Histopathology showed typical acanthotic type of seborrheic keratosis characterized by basaloid keratinocyte proliferation pseudohorn cysts. Many aggregated xanthomatized cells were seen papillae within the epithelium....
Prurigo pigmentosa is a rare inflammatory dermatosis whose exact etiology not understood yet. The purpose of this study was to provide evidence hair follicle involvement in the pathogenesis by analyzing its clinicopathologic features.Patients who fulfilled both clinical and histological diagnostic criteria prurigo were recruited. Their histopathologic findings, features medical histories analyzed.A total 32 confirmed patients enrolled from 2002 2013. ages ranged 11 79 years with female...
<b><i>Background/Aims:</i></b> Cutaneous plasmacytosis is rare and still not well understood. A retrospective study was made of 9 Chinese patients with 1- to 15-year histories biopsy-proven cutaneous diagnosed between 2003 2015. <b><i>Methods:</i></b> Patient records archival photographs helped establish the pattern duration skin lesions, biopsy specimens provided additional data. <b><i>Results:</i></b> The mean age at...
Making a clinical and histological distinction between condyloma seborrheic keratosis in the genitofemoral area can be difficult. This study aimed to find reliable immunohistological criteria diagnose these entities. We retrospectively studied skin biopsy specimens obtained January 2004 December 2007 that had been diagnosed as showing or keratosis. The findings were assessed immunohistochemical stains performed for human papillomavirus, Ki-67, p21. DNA was extracted from paraffin sections...