A5078022468- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer, Stress, Anesthesia, and Immune Response
- Carcinogens and Genotoxicity Assessment
- Hemodynamic Monitoring and Therapy
- Airway Management and Intubation Techniques
- Cardiac Arrest and Resuscitation
- Intensive Care Unit Cognitive Disorders
- Air Quality and Health Impacts
- Healthcare and Environmental Waste Management
- Climate Change and Health Impacts
- Respiratory Support and Mechanisms
- Cardiac Ischemia and Reperfusion
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Effects and risks of endocrine disrupting chemicals
- Veterinary Pharmacology and Anesthesia
- Neonatal Respiratory Health Research
- Aortic aneurysm repair treatments
- Animal testing and alternatives
- Thermal Regulation in Medicine
- Chemical Analysis and Environmental Impact
- Chemical Safety and Risk Management
- Diet, Metabolism, and Disease
- Pediatric health and respiratory diseases
Universidade Estadual Paulista (Unesp)
2016-2025
Surgical Specialties (United States)
2024
Centro Universitário de João Pessoa
2023
Tufts University
2014-2020
Jean Mayer Human Nutrition Research Center on Aging
2020
Fundação de Apoio à Universidade Federal de São Paulo
2014-2017
GTx (United States)
2009
University of Reading
1939
In 2006, a previous study at our institution reported high perioperative and anesthesia-related mortality rates of 21.97 1.12 per 10,000 anesthetics, respectively. Since then, changes in surgical practices may have decreased these rates. However, the actual Brazil remains unknown. The aimed to reexamine one Brazilian tertiary teaching hospital.In this observational study, deaths occurring operation room postanesthesia care unit between April 2005 December 2012 were identified from an...
To investigate the effects of occupational exposure to waste anesthetic gases on genetic material and antioxidant status in professionals during their medical residency.The study group consisted 15 residents from Anesthesiology Surgery areas, both genders, mainly exposed isoflurane a lesser degree sevoflurane nitrous oxide; control young adults not anesthetics. Blood samples were drawn residency (eight, 16 22 months gases). DNA damage was evaluated by comet assay, defense assessed total...
Abstract The objective of this longitudinal study was to jointly assess DNA damage, apoptosis, inflammatory marker levels and white blood cell (WBC) counts in physicians occupationally exposed inhalation anesthetics during specializations. Thus, we aimed identify a possible cause-effect relationship between occupational exposure waste anesthetic gases (WAGs), which were measured, genotoxic, cytotoxic immunotoxic effects. Nineteen medical residents evaluated at four time points: before...
Recent studies have demonstrated the genotoxicity of anesthetics in patients who undergone surgery and personnel are occupationally exposed to anesthetics. However, these findings controversial. Herein, we used comet assay (single-cell gel electrophoresis) investigate genotoxic effects two volatile compounds [isoflurane (ISF) sevoflurane (SVF)] that inhalation anesthesia, one intravenous (iv) anesthetic compound [propofol (PF)]. The groups consisted 45 underwent minimally invasive lasted at...
Isoflurane is a volatile halogenated anesthetic used especially for anesthesia maintenance whereas propofol venous utilized induction and maintenance, reportedly an antioxidant. However, there are still controversies related to isoflurane-induced oxidative stress it remains unanswered whether the antioxidant effects occur in patients under anesthesia. Taking into account importance of better understanding role anesthetics on anesthetized patients, present study was designed evaluate general...
The waste anesthetic gases (WAGs) present in the ambient air of operating rooms (OR), are associated with various occupational hazards. This paper intends to discuss exposure WAGs and its impact on exposed professionals, emphasis genetic damage oxidative stress. Despite emergence safer inhaled anesthetics, remains a current concern. Factors related techniques anesthesia workstations, addition absence scavenging system OR, contribute pollution. In order minimize health risks several countries...
summary Mineral trioxide aggregate (MTA) and Portland cement are being used in dentistry as root‐end‐filling material for periapical surgery the sealing of communications between root canal system surrounding tissues. However, genotoxicity tests complete risk assessment these compounds have not been conducted up to now. In present study, genotoxic effects MTA cements were evaluated peripheral lymphocytes from 10 volunteers by alkaline single cell gel (comet) assay. The results pointed out...
There are numerous studies reporting on the effects of inhalation anaesthesia in cells exposed individuals but not much is known about ability isoflurane (ISF) to induce oxidative DNA damage. However, surgery often associated with a temporary perioperative immunological alteration, and some volatile anaesthetics seem contribute transient lymphocytopenia after surgery. We conducted study evaluate possible genotoxic effect, including damage, apoptosis peripheral lymphocytes 20 patients...
The mechanism of doxorubicin (DOX)-induced cardiotoxicity remains controversial. Wistar rats (n = 66) received DOX injections intraperitoneally and were randomly assigned to 2 experimental protocols: (1) killed before (-24 h, n 8) 24 h after (+24 a single dose (4 mg/kg body weight) determine the acute effect (2) 58) 4 weight/week) first injection (M0) 1 week each (M1, M2, M3, M4) chronological effects. Animals used at M0 also moment -24 study. Cardiac total antioxidant performance (TAP), DNA...
Taking into account that there are controversial antioxidative effects of inhalational anesthetics isoflurane and sevoflurane absence comparison genotoxicity both in animal model, the aim this study was to compare DNA damage antioxidant status Wistar rats exposed a single time or sevoflurane. The alkaline single-cell gel electrophoresis assay (comet assay) performed order evaluate whole blood cells control animals (unexposed; n = 6) those 2% ( 4% for 120 min. Plasma determined by...
This cross-sectional study analyzed the impact of occupational waste anesthetic gases on genetic material, oxidative stress, and inflammation status in young physicians exposed to inhalational anesthetics at end their medical residency. Concentrations were measured operating rooms assess pollution. The group comprised individuals occupationally anesthetics, while control without exposure. We quantified DNA damage; instability (micronucleus-MN); protein, lipid, oxidation; antioxidant...
The effects of hydroethanolic extract Yacon leaves (HEYL) on antioxidant, glycemic, and inflammatory biomarkers were tested in diabetic rats. Outcome parameters included glucose, insulin, interleukin-6 (IL-6), hydrophilic antioxidant capacity (HAC) serum IL-6, HAC, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) soleus. rats (10/group) divided as follows: C, controls; C + Y, HEYL treated; DM, DM treated with HEYL. Diabetes mellitus was induced...
Abstract Propofol, which is widely used as an intravenous anesthetic, has a phenolic structure similar to that of α‐tocopherol with antioxidant properties could prevent genotoxicity and cytotoxicity in lymphocytes anesthetized patients. The aims this study were evaluate oxidative DNA damage apoptosis the expression repair genes blood cells from patients undergoing elective surgery under anesthesia propofol. Twenty healthy adults both genders (18–50 years old) who scheduled for...
Abstract We demonstrate the efficacy of propofol (2,6‐diisopropylphenol) as an anesthetic when administered to fish in immersion bath and show absence genetic side effects following short‐term exposure drug. All tested were anesthetized (as indicated by loss posture lack response physical stimulation), both comet assay (tail intensity) micronucleus revealed that does not induce primary DNA damage or chromosome Nile Tilapia Oreochromis niloticus . Our results should be considered light our...
Abstract This cross‐sectional study evaluated, for the first time, DNA damage, viability, and cell death of lymphocytes cycle phases mononuclear polymorphonuclear cells in veterinarians exposed to volatile anesthetic isoflurane. Veterinarians who were occupationally isoflurane (exposed group; n = 20) matched‐unexposed individuals (volunteers without occupational exposure; enrolled study. damage was assessed by micronucleus (MN) phosphorylated histone gamma‐H2AX (γ‐H2AX). Cell cytotoxicity,...
Summary Background Intra‐operative cardiac arrest is a rare but life‐threatening event. Over the past two decades, various initiatives have improved care of patients undergoing surgery at our quaternary teaching hospital in Brazil. We aimed to evaluate epidemiology intra‐operative and associated 30‐day mortality over an 18‐year period. A secondary aim was identify risk factors. Methods conducted retrospective observational study using data collected from 1 January 2005 31 December 2022....