A5100368222- Antibiotic Resistance in Bacteria
- Hydrogels: synthesis, properties, applications
- Pneumonia and Respiratory Infections
- Bacterial Identification and Susceptibility Testing
- Bacteriophages and microbial interactions
- Antibiotics Pharmacokinetics and Efficacy
- Electrospun Nanofibers in Biomedical Applications
- Cystic Fibrosis Research Advances
- Tracheal and airway disorders
- Curcumin's Biomedical Applications
- Bone Metabolism and Diseases
- Vibrio bacteria research studies
- Biosensors and Analytical Detection
- Advanced Materials and Mechanics
- Bone and Dental Protein Studies
- Polymer Nanocomposites and Properties
- Bacterial Genetics and Biotechnology
- Advanced Sensor and Energy Harvesting Materials
- Tuberculosis Research and Epidemiology
- Escherichia coli research studies
- Microbial infections and disease research
- Mycobacterium research and diagnosis
- Antibiotic Use and Resistance
- Heme Oxygenase-1 and Carbon Monoxide
- Advanced Cellulose Research Studies
Jilin University
2024
Jiaxing University
2019-2024
First Hospital of Jiaxing
2020-2024
Central People's Hospital of Zhanjiang
2021-2024
Chengdu University of Traditional Chinese Medicine
2024
Xinjiang Agricultural University
2024
Jiangxi Academy of Agricultural Sciences
2023
Animal Science Research Institute
2023
Bengbu Medical College
2022
Binzhou Medical University
2022
Poultry is one of the most commonly farmed species and widespread meat industries. However, numerous poultry flocks have been long threatened by pathogenic bacterial infections, especially antimicrobial resistant pathogens. Here prevalence resistance (AMR) profiles pathogens isolated from in Jiangxi Province, China were investigated. From 2020 to 2022, 283 tissue liquid samples collected clinically diseased poultry, including duck, chicken, goose, with an overall positive isolation rate...
Rapid and accurate pathogen identification is essential for the treatment of pneumonia. Metagenomic next-generation sequencing (mNGS) a newly developed technology to obtain microbial nucleic acid sequence information quickly, efficiently, without bias.We performed shotgun metagenomic bronchoalveolar lavage fluid (BALF) in pneumonia prospective study with 138 patients from single center. We compared results mNGS standard methods including culture, staining, targeted PCR evaluated clinical...
ABSTRACT A kind of novel hemicellulose‐based hydrogel with excellent water absorbency was synthesized by the graft copolymerization acrylic acid (AA), amide (AM) hemicellulose. The various factors that influenced modified hemicellulose were studied, including AA content, neutralization degree AA, and weight ratio (to monomer) cross‐linker initiator. optimal conditions found as follows: m(AA) : m(AM) m(hemicellulose) = 15 3.5 1, 75%, monomers) initiator 0.03% 1.0%, respectively. maximum...
Abstract This paper presents a compact broadband antenna that overcomes bandwidth limitations in diamond NV center-based quantum magnetic sensor. Conventional antennas struggle to achieve both operation and integration, restricting the sensitivity dynamic range of The based on dual-frequency monopole structure achieves extension 777 MHz at Zeeman splitting frequency 2.87 GHz, with dual resonant points positioned near GHz. Additionally, high-resolution imaging microwave field surface was...
Abstract Background Bronchiectasis is a chronic inflammatory respiratory disease mainly caused by pathogenic infections. However, standard methods of pathogen detection show prolonged cycle durations and unsatisfactory sensitivity rates. Macrogenomic next-generation sequencing (mNGS) emerges as promising technique for swift, effective, unbiased subsequent data interpretation. Methods Here, retrospective analysis 93 patients with suspected bronchiectasis was performed to assess the clinical...
The tough polyacrylamide/Laponite/titania (TiO 2 ) dual nanocomposite (NC) hydrogel was fabricated by in situ radical polymerization of acrylamide (AAm) the dispersion Laponite and TiO . nanoparticles were prepared sol‐gel method used as both inorganic filler multi‐functional crosslinking agent. morphology tuned functions sodium hydroxide (NaOH) concentration ratio Ti (mmol) to clay (g) (mmol Ti/g clay). SEM HR‐TEM morphologies revealed that tended form a uniform regular microstructure like...
ABSTRACT Laponite or graphene oxide (GO) is usually used as a multifunctional crosslinker nanofiller to improve the nanocomposite gel strength. To explore strengthening mechanism of GO/Laponite‐based dual hydrogels, we synthesized hydrogel through in situ polymerization acrylamide (AM) dispersion GO and Laponite. The interactions between were confirmed by rheological test. nanosheets exfoliated well dispersed uniformly hydrogels at low concentration GO. Crosslinking network thermal behaviors...
The emergence of carbapenemase-producing Enterobacterales (CPE) infections is a major global public health threat. Rapid and accurate detection pathogenic bacteria essential to optimize treatment timely avoid further transmission these bacteria. Here, we aimed develop rapid on site visualization method for CPE using improved recombinase polymerase amplification (RPA) combined with lateral flow strip (LFS) method, based four most popular carbapenemase genes: bla KPC , NDM OXA-48-like IMP ....
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Anti-restriction proteins are typically encoded by plasmids, conjugative transposons, or phages to improve their chances of entering a new bacterial host with type I DNA restriction and modification (RM) system. The invading is normally destroyed the RM anti-restriction ArdA, KlcA, homologues usually on plasmid carbapenemase-resistant Klebsiella pneumoniae . We found that sequence affected horizontal gene transfer, confirmed anti-methylation activities ArdA KlcA during transformation...
Although the clinical features of
The second messenger c-di-GMP [bis-(3′-5′)-cyclic dimeric guanosine monophosphate] plays a key role in bacterial growth, survival and pathogenesis, thus its intracellular homeostasis should be finely maintained. Mycobacterium smegmatis encodes GAF (mammalian cGMP-regulated phosphodiesterases, Anabaenaadenylyl cyclases Escherichia coli transcription activator FhlA) domain containing bifunctional enzyme DcpA (diguanylate cyclase phosphodiesterase A) that catalyzes the synthesis hydrolysis of...
Highly virulent Klebsiella pneumoniae often causes invasive infections with high morbidity and mortality rates, posing an immense clinical challenge. Rapid accurate detection of pathogenic bacteria is great significance for treatment preventive control. Conventional by polymerase chain reaction (PCR) limited a dependence on laboratory equipment professional staff. Recombinase amplification (RPA) combined lateral flow strip (LFS) can rapidly amplify visualize target genes in short period...
The inappropriate use of cephalosporins lead to the occurrence and global spread bacteria resistant these antimicrobials. In this study, we isolated four Escherichia albertii (E. albertii) strains from broilers in Eastern China. antimicrobial susceptibility genomic characterization E. isolates were determined. Our results revealed that exhibited resistance tetracyclines, chloramphenicol, β-lactams, aminoglycosides, polymyxin B, sulfonamides, quinolones, other Among them, EA04 isolate was...
Chronic obstructive pulmonary disease (COPD) is one of the most prevalent and severe diseases worldwide with high societal health care costs. The pathogenesis COPD very complicated, no curative treatment available. Cellular senescence promotes development COPD. Type II alveolar epithelial cells (AECII) play a momentous role in lung tissue repair maintenance homeostasis. Sirtuin 1 (SIRT1), an antiaging molecule involved response to chronic inflammation oxidative stress, regulates many...
Abstract This study aimed to investigate the disparities between metagenomic next-generation sequencing (mNGS) and conventional culture results in patients with bronchiectasis. Additionally, we sought correlation clinical characteristics of their microbiome profiles. The overarching goal was enhance effective management treatment bronchiectasis patients, providing a theoretical foundation for healthcare professionals. A retrospective survey conducted on 67 admitted First Hospital Jiaxing...
The outer membrane (OM) of Gram-negative bacteria is an evolving antibiotic barrier composed a glycerophospholipid (GP) inner leaflet and lipopolysaccharide (LPS) leaflet. two-component regulatory system CrrAB has only recently been reported to confer high-level polymyxin resistance virulence in Klebsiella pneumoniae. Mutations crrB have shown lead the modification lipid A moiety LPS through activation. However, functions activation regulation other lipids are unclear. Work here demonstrates...
The clinical isolation rates of carbapenem-resistant Klebsiella pneumoniae (CR-KP) continue to increase. In China, CR-KP isolates are mainly attributed the blaKPC-2 gene carried on plasmids, and copy number correlates with expression KPC enzymes, which can cause elevated carbapenem MICs.Thirty-seven were collected at Second People's Hospital Lianyungang City between January 2020 March 2021, no duplicate isolates, screened for PCR. Analysis current CRKP resistance clinically relevant...
Hypervirulent Klebsiella pneumoniae (hvKP) with a high mucus phenotype, can cause liver abscess and extrahepatic invasive infection. The morbidity of hvKP infections has increased recently. Here we describe case report septicemia caused by due to the term septic arthritis right knee joint in 29-year-old male. patient was persistent fever peak temperature at 40.6 °C. However, based on drug sensitivity, treatment failed frequently. did not improve clinically susceptible monotherapy...
Three-network hydrogels have a wide range of applications due to their different network structures and diverse cross-linking methods. In this work, triple-network hydrogel strategy based on double coordination is proposed, including gelatin (Gelatin) network, polyacrylamide acrylic acid (PAMAAc) sodium alginate (SA) network. SA AAc molecular chains contain large amount -COO-, which can coordinate with metal ions generate number dynamic bonds. The forms the PAMAAc through free radical...