A5066296813- Elasticity and Material Modeling
- Connective tissue disorders research
- Cardiovascular Health and Disease Prevention
- Aortic aneurysm repair treatments
- Coronary Interventions and Diagnostics
- Aortic Disease and Treatment Approaches
- Cardiomyopathy and Myosin Studies
- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
- Cellular Mechanics and Interactions
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Sirtuins and Resveratrol in Medicine
- Cardiac Valve Diseases and Treatments
- Effects of Vibration on Health
Boston University
2015-2023
Sirtuin-1 (SirT1), a nicotinamide adenine dinucleotide(+)-dependent deacetylase, is key enzyme in the cellular response to metabolic, inflammatory, and oxidative stresses; however, role of endogenous SirT1 vasculature has not been fully elucidated. Our goal was evaluate vascular smooth muscle physiological aortic wall angiotensin II, potent hypertrophic, oxidant, inflammatory stimulus.Mice lacking (ie, knockout) had drastically high mortality (70%) caused by dissection after II infusion (1...
Aortic dissection is a devastating cardiovascular disease known for its rapid propagation and high morbidity mortality. The mechanisms underlying the of aortic are not well understood. Our study reports discovery avalanche-like failure aorta during that results from local buildup strain energy followed by cascade inhomogeneously distributed interlamellar collagen fibers. An innovative computational model was developed successfully describes mechanics propagation. provides first quantitative...
Microstructural deformation of elastic lamellae plays important roles in maintaining arterial tissue homeostasis and regulating vascular smooth muscle cell fate. Our study unravels the underlying microstructural origin that enables lamellar layers to evenly distribute stresses through wall caused by intraluminal distending pressure, a fundamental requirement for cellular function. A new experimental approach was developed quantify spatial organization unfolding under pressurization mouse...
Metabolic syndrome increases the risk of cardiovascular diseases. Arteries gradually stiffen with aging; however, it can be worsened by presence conditions associated metabolic syndrome. In this study, we investigated combined effects diet-induced and aging on biomechanical properties mouse common carotid arteries (CCA). Male mice at 2 months age were fed a normal or high fat sucrose (HFHS) diet for (young group), 8 (adult group) 18–20 (old months. CCAs excised subjected to in vitro biaxial...
Arterial stiffening is a hallmark of aging, but how aging affects the arterial response to pressure still not completely understood, especially with regard specific matrix metalloproteinases (MMPs). Here, we performed biaxial inflation-extension tests on C57BL/6 mice study effects age and MMP12, major elastase, biomechanics. Aging from 2 24 months leads both circumferential axial stretch, these changes are associated an increased wall thickness, decreased inner radius-wall thickness ratio,...
Inter-fiber crosslinks within the extracellular matrix (ECM) play important roles in determining microstructural kinematics and mechanics of fibrous network. Discrete fiber network (DFN) models have been used to study biological material, however contribution inter-fiber is not well understood. In this study, a DFN model arterial elastin was developed based on measured structural features crosslinking properties density The generated by randomly placing line segments into given domain...