A5028345995- Elasticity and Material Modeling
- Connective tissue disorders research
- Coronary Interventions and Diagnostics
- Cardiovascular Health and Disease Prevention
- Aortic aneurysm repair treatments
- Cellular Mechanics and Interactions
- Force Microscopy Techniques and Applications
- Advanced MEMS and NEMS Technologies
- Mechanical and Optical Resonators
- Collagen: Extraction and Characterization
- Cardiovascular Function and Risk Factors
- Statistical Methods and Inference
- Adhesion, Friction, and Surface Interactions
- Bone Tissue Engineering Materials
- Single-cell and spatial transcriptomics
- Cancer Cells and Metastasis
- Cardiomyopathy and Myosin Studies
- Sparse and Compressive Sensing Techniques
- Aortic Disease and Treatment Approaches
- Hippo pathway signaling and YAP/TAZ
- Thermoregulation and physiological responses
- Fault Detection and Control Systems
- Heart Rate Variability and Autonomic Control
- Advanced Fluorescence Microscopy Techniques
- Acoustic Wave Resonator Technologies
Boston University
2016-2025
Harbin Institute of Technology
2018-2019
Beijing Normal University
2017
Boston Engineering (United States)
2015
Tsinghua University
2014-2015
Institute of Microelectronics
2015
University of Colorado Boulder
2003-2005
University of Colorado System
1999-2001
Many biological tissues are piezoelectric and pyroelectric with spontaneous polarization. Ferroelectricity, however, has not been reported in soft yet. Using piezoresponse force microscopy, we discover that the porcine aortic walls only piezoelectric, but also ferroelectric, coefficient order of $1\text{ }\text{ }\mathrm{pm}/\mathrm{V}$ coercive voltage approximately 10 V. Through detailed switching spectroscopy mapping relaxation studies, find polarization is internally biased outward,...
In the last several years, we have witnessed significant advances in molecular ferroelectrics, with ferroelectric properties of crystals approaching those barium titanate. addition, ferroelectricity has been observed biological systems, filling an important missing link bioelectric phenomena. this perspective, will present short historical notes on followed by overview fundamentals ferroelectricity. The latest developments ferroelectrics and then be highlighted, their implications potential...
Significance Ferroelectricity has long been speculated to have important biological functions, although its very existence in biology never firmly established. Here, we present, our knowledge, the first macroscopic observation of ferroelectric switching a system, and elucidate origin mechanism underpinning elastin. It is discovered that polarization elastin intrinsic at monomer level, analogous unit cell level classical perovskite ferroelectrics. Our findings settle long-standing question on...
Elastin is an intriguing extracellular matrix protein present in all connective tissues of vertebrates, rendering essential elasticity to subjected repeated physiological stresses. Using piezoresponse force microscopy, we show that the polarity aortic elastin switchable by electrical field, which may be associated with recently discovered biological ferroelectricity aorta. More interestingly, it switching largely suppressed glucose treatment, appears freeze internal asymmetric polar...
Collagen type I scaffolds are commonly used due to its abundance, biocompatibility, and ubiquity. Most applications require the operate under mechanical stresses. Therefore understanding being able control structural-functional integrity of collagen becomes crucial. Using a combined experimental modeling approach, we studied structure function Type gel with effects spatial fiber alignment crosslinking. Aligned were created through flow magnetic particles enmeshed in fibrils mimic anisotropy...
As major extracellular matrix components, elastin, and collagen play crucial roles in regulating the mechanical properties of aortic wall and, thus, normal cardiovascular function. The aorta, known to vary with age multitude diseases as well proximity heart, have been attributed variations content architecture constituents. This study is focused on role layer-specific undulation variation along porcine descending thoracic aorta. Planar biaxial tensile tests are performed characterize...
Sirtuin-1 (SirT1), a nicotinamide adenine dinucleotide(+)-dependent deacetylase, is key enzyme in the cellular response to metabolic, inflammatory, and oxidative stresses; however, role of endogenous SirT1 vasculature has not been fully elucidated. Our goal was evaluate vascular smooth muscle physiological aortic wall angiotensin II, potent hypertrophic, oxidant, inflammatory stimulus.Mice lacking (ie, knockout) had drastically high mortality (70%) caused by dissection after II infusion (1...
This study aims to provide understanding of the macroscopic viscoelastic behavior collagen matrices through studying relaxation time distribution spectrum obtained from stress tests. Hydrated gel and dehydrated thin film was exploited as two different hydration levels matrices. Genipin solution used induce crosslinking in Biaxial tests were performed characterize The rate both hydrated shows a linear initial level dependency. Increased reduces viscosity gel, but effect is negligible for...
Aortic dissection is a devastating cardiovascular disease known for its rapid propagation and high morbidity mortality. The mechanisms underlying the of aortic are not well understood. Our study reports discovery avalanche-like failure aorta during that results from local buildup strain energy followed by cascade inhomogeneously distributed interlamellar collagen fibers. An innovative computational model was developed successfully describes mechanics propagation. provides first quantitative...
Hard Thresholding Pursuit (HTP) has aroused increasing attention for its robust theoretical guarantees and impressive numerical performance in non-convex optimization. In this paper, we introduce a novel tuning-free procedure, named Full-Adaptive HTP (FAHTP), that simultaneously adapts to both the unknown sparsity signal strength of underlying model. We provide an in-depth analysis iterative thresholding dynamics FAHTP, offering refined insights. specific, under beta-min condition $\min_{i...
The double sparse linear model, which has both group-wise and element-wise sparsity in regression coefficients, attracted lots of attention recently. This paper establishes the sufficient necessary relationship between exact support recovery optimal minimum signal conditions model. Specifically, sharply under proposed conditions, a two-stage iterative hard thresholding procedure achieves with suitably chosen threshold parameter. Also, this maintains asymptotic normality aligning an OLS...
Joint estimation of multiple graphical models (i.e., precision matrices) has emerged as an important topic in statistics. Unlike separate estimation, joint can leverage shared structural patterns across graphs to yield more accurate results. In this paper, we present efficient and tuning-free method named MIGHT (Multi-task Iterative Graphical Hard Thresholding) jointly estimate models. We reformulate the model into a series multi-task learning problems column-by-column manner, then solve...