A5101584369- RNA modifications and cancer
- Neonatal Respiratory Health Research
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Immune Response and Inflammation
- Epilepsy research and treatment
- Ubiquitin and proteasome pathways
- Pharmacological Effects of Natural Compounds
- Cancer Immunotherapy and Biomarkers
- Rheumatoid Arthritis Research and Therapies
- Pharmacological Effects and Toxicity Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related Molecular Pathways
- Flavonoids in Medical Research
- Computational Drug Discovery Methods
- Vasculitis and related conditions
- Neonatal and fetal brain pathology
- Cardiac Arrhythmias and Treatments
- Pulmonary Hypertension Research and Treatments
- Systemic Lupus Erythematosus Research
- Neurology and Historical Studies
- Infant Nutrition and Health
- Galectins and Cancer Biology
- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
Xiangya Hospital Central South University
2024
Central South University
2024
Second Hospital of Shandong University
2011-2023
Hainan General Hospital
2020-2022
Hainan Medical University
2020
Shandong University
2013
The present study aimed to investigate the expression of microRNA (miRNA) 26a in blood mononuclear cells and serum neonatal sepsis, as well its role disease pathogenesis. In total 28 cases sepsis were included study. mRNA levels miRNA-26a interleukin (IL)-6 samples detected by reverse transcription-quantitative polymerase chain reaction. protein IL-6 was western blot analysis ELISA. vitro septic environment simulated lipopolysaccharide (LPS) THP-1 cells, determined. Interaction between...
Abstract Necrotizing enterocolitis (NEC) is a critical neonatal disease with high mortality. The possibility that miRNAs may play an important role in NEC has raised great attention. Hence, the present study identified biomarkers affected newborn progression through miRNA and gene expression profile analysis. chip GSE68054 GSE46619 of were analyzed to screen out differentially expressed genes (DEGs). Next, target predicted, miRNA-DEG regulatory network was constructed select key miRNAs....
Abstract Pituitary adenomas constitute one of the most common intracranial tumors. MicroRNAs play an important role in development and progression pituitary adenomas. In this study, we showed that miR-219a-2-3p was significantly down-regulated cells. Overexpression suppressed proliferation promoted apoptosis After bioinformatics analysis, found MDM2 downstream targets miR-219a-2-3p. Further researches could reduce protein level by binding to 3ʹ-UTR p53 expression. Then, overexpressed both...
Objective To investigate the feasibility of transferring p21 gene into lung tissue with recombinant adenovirus full-length cDNA D21 inserted in Wistar rat model pulmonary hypertension(PAH)induced by left-to-right shunt,study expression desired vivo,find if overexpression can inhibit hypertension.Methods With transfected HEK293 cells clonfectin.and was packed.amplified order to obtain high-titer adenovirus(AdCMV-p21).The infection titer determined TCID50 method and diluted 1.67 x 108...
The role of homologous recombination deficiency (HRD) in lower grade glioma (LGG) has not been elucidated, and accurate prognostic prediction is also important for the treatment management LGG. aim this study was to construct an HRD-based risk model explore immunological molecular characteristics model. HRD score threshold = 10 determined from 506 LGG samples Cancer Genome Atlas cohort using best cut-off value, patients with high scores had worse overall survival. A total 251 HRD-related...
Abstract Background: Bronchopulmonary dysplasia (BPD) is a complex disorder resulting from interactions between genes and the environment. The precise molecular etiology of BPD remains unclear. This study aimed to determine potential biomarkers possible therapeutic targets through competitive endogenous RNA (ceRNA) network analysis lay foundation for future clinical research. Methods : First, we downloaded mRNA, miRNA, long non-coding (lncRNA) expression profiles patients with Comprehensive...