Objective— ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats-13) cleaves von Willebrand factor, thereby modulating thrombosis inflammation. Low plasma activity is associated cardiovascular events, including myocardial cerebral infarction. Here, we investigated the role of in development early atherosclerosis a murine model. Methods Results— Apolipoprotein E–null (ApoE −/− ) Adamts13-null (Adamts13 ApoE mice were fed high-fat Western diet for 12 weeks....

Psoriasis is one of the most common immune-mediated chronic inflammatory skin disorders, characterized by hyperproliferation keratinocytes, dilation and growth dermal capillary vasculature, cellular infiltration T cells, dendritic cells (DCs), neutrophils. Paeoniflorin (PF), principal component total glucosides paeony (TGP), displays anti-inflammatory antioxidant properties in several animal models. In this study, we investigated effects mechanisms PF imiquimod (IMQ)-induced psoriasis-like...

High-mobility group box-1 (HMGB1) has been implicated as a pro-inflammatory cytokine in the pathogenesis of various inflammatory and autoimmune diseases. However, information about HMGB1 Henoch-Schönlein purpura (HSP) is still unclear. Herein, we investigated role patients with HSP effects on human dermal microvascular endothelial cell line (HMEC-1). Serum levels together allergic vasculitis (AV) urticarial (UV) were detected by enzyme-linked immunosorbent assay (ELISA). HMEC-1 cells treated...

SOCS3 is tumor suppressor which has been identified as upstream of JAK/STAT3 signaling by specific kinase inhibition. However, additional regulations especially through a non-coding RNA approach were remained unknown.We performed case-control study focusing on the miRNAs associated SNPs in to investigate further relationship with among Chinese gastric cancer (GC) patients. Genotyping, real time PCR assay, cell transfection and dual luciferase reporter assay used our study.We found that...

In the previous work, we have indicated that HMGB1, a pro-inflammatory cytokine, is closely associated with pathogenesis of psoriasis. To further clarify role HMGB1 in psoriasis, investigated direct function application and blockade imiquimod (IMQ)-induced psoriatic mouse model this study. Mice were treated (IMQ) to induce psoriasis-like inflammation, consecutively injected recombinant or phosphate-buffered saline (PBS) i.d. Abundant cytoplasmic expression was observed lesional skin from...

Abstract Tumor necrosis factor ( TNF )‐like weak inducer of apoptosis TWEAK ), a member the family, has been implicated as pro‐inflammatory cytokine in many types autoimmune and infectious diseases. However, information about dermatological diseases is limited. To date, no studies have investigated roles patients with urticarial vasculitis UV ). This study aimed to assess serum levels, together fibroblast growth factor‐inducible 14 F n14) expressions skin lesions . Serum levels , cutaneous...

Interferon (IFN)-λ1, also named Interleukin (IL)-29, is a new member of the Type III IFN or IFN-λ family. IL-29 plays an important role in pathogenesis many types autoimmune and inflammatory diseases. To study psoriasis vulgaris. The authors detected serum levels forty-one patients with vulgaris, twenty-three atopic dermatitis thirty-eight age gender-matched controls by sandwich Enzyme-Linked Immunosorbent Assay (ELISA). effects on expression cytokines, such as IL-6, IL-17, IL-8, IL-4, IL10,...

Glycolysis is an important metabolic oncogenic change also play a pivot role in the Warburg effect. related gene PKM2 expressed differently individually. Presently, we sought to investigate effect of single nucleotide polymorphism (SNP) at rs61991156 miR-379 on gastric cancer (GC) proliferation and metabolism. The genotype was investigated by using real-time PCR. glycolysis-related metabolites were determined GC–TOF–MS. biological effects explored vitro studies. In this study, found that...

Monoammonim glycyrrhizate (MAG) derived from licorice has been shown to have anti-inflammatory properties. Chemokines are vital inflammatory mediators that involved with endothelial damage leukocyte infiltrates in various skin diseases. In this study, we investigated the effects and mechanisms of MAG on tumor necrosis factor-α (TNF-α) induced chemokine production a human dermal microvascular cell line (HMEC-1). HMEC-1 cells were treated TNF-α, or without MAG. The results showed suppressed...

Tumour necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) is a pro-inflammatory cytokine, which closely associated with the pathogenesis various types cutaneous vasculitis (CV).To investigate therapeutic effects an anti-TWEAK monoclonal antibody (mAb) in mouse model reverse passive Arthus (RPA) reaction.Cutaneous RPA reaction was induced BALB/c mice by intradermal injection anti-ovalbumin IgG into left ear followed immediately intravenous chicken ovalbumin. After treatment,...

Abstract Benzoic acid naturally exists in a variety of plants and fermented foods, jujube contains natural benzoic acid. This study scrutinises the content diverse cultivars, its modulation by variables such as harvest timing, product types, drying techniques. The methodology encompasses tracking progressive augmentation throughout maturation process jujube, with apex being 144.4 mg kg −1 Junzao cultivar. It further investigates substantial fluctuations powder under disparate processing...

Objective: Anti-high-mobility group box 1 (HMGB1) is involved in the pathogenesis of many inflammatory and autoimmune diseases, including psoriasis. The present study aimed to investigate therapeutic effects HMGB1 monoclonal antibody (mAb) keratin 14 (K14)-vascular endothelial growth factor (VEGF) transgenic homozygous mice. Methods: Twelve VEGF mice were randomly divided into two groups six each: anti-HMGB1 mAb immune complex (IC) group. underwent intraperitoneal injection or IC once every...