A5089997177- Advanced Measurement and Metrology Techniques
- Adaptive optics and wavefront sensing
- Carbon and Quantum Dots Applications
- Biosensors and Analytical Detection
- Mycotoxins in Agriculture and Food
- Optical Systems and Laser Technology
- Optical measurement and interference techniques
- Sensor Technology and Measurement Systems
- Selenium in Biological Systems
- Advanced Image Processing Techniques
- Advanced biosensing and bioanalysis techniques
- HVDC Systems and Fault Protection
- Gene expression and cancer classification
- Cardiac Structural Anomalies and Repair
- RNA modifications and cancer
- Astronomical Observations and Instrumentation
Zhejiang Cancer Hospital
2024-2025
Chinese Academy of Sciences
2018-2025
Institute of Optics and Electronics, Chinese Academy of Sciences
2018-2020
University of Chinese Academy of Sciences
2018-2020
DNA-related enzymes are associated with various diseases and have been potential biomarkers for clinical diagnosis. Developing robust ultrasensitive methods is extremely favorable the detection of these biomarkers. To this purpose, a primer-regulated rolling circle amplification (RCA) strategy was ingeniously proposed. Briefly, RCA primer, which invalidated 3'-inverted dT (locked state) unable to initiate an reaction by phi29 DNA polymerase, embedded recognition substrate specific enzyme. In...
Molecular diagnosis of biliary tract cancer (BTC) remains a significant clinical challenge due to the lack sensitive and specific diagnostic tools. Although large panels based on multi‐biomarkers have demonstrated potential in enhancing accuracy, their application is hindered by complexity high costs. To overcome these limitations, we developed DNA‐based molecular computation system that integrates detection plasma circular RNAs (circRNAs) with computation, enabling intelligent rapid BTC. By...
Molecular diagnosis of biliary tract cancer (BTC) remains a significant clinical challenge due to the lack sensitive and specific diagnostic tools. Although large panels based on multi‐biomarkers have demonstrated potential in enhancing accuracy, their application is hindered by complexity high costs. To overcome these limitations, we developed DNA‐based molecular computation system that integrates detection plasma circular RNAs (circRNAs) with computation, enabling intelligent rapid BTC. By...
The next generation of optical telescopes will provide high-resolution imaging celestial objects by using the aperture synthesis technique. To preserve quality image, fast corrections pistons among subapertures have to be applied, namely, co-phasing array. image-based method via an optimization procedure has been newly developed. Despite simplicity and strong commonality, when dealing with large piston errors, this correction is also faced a problem in which metric function easily falls into...
Post-transcriptional modification of N6-methyladenosine (m6A) is crucial for ribonucleic acid (RNA) metabolism and cellular function. The ability to visualize site-specific m6A methylation at the single-cell level would markedly enhance our understanding its pivotal regulatory functions in field epitranscriptomics. Despite this, current situ imaging techniques are constrained, posing a significant barrier epitranscriptomic studies pathological diagnostics. Capitalizing on precise targeting...
Photoelectric angle encoders, working as position sensors, have a great influence on the accuracy and stability of telescope control systems (TCS). In order to improve tracking precision TCS, method based subdivision error compensation for photoelectric encoders is proposed. First, mathematical analysis six types errors (DC error, phase amplitude harmonic noise quantization error) presented, which different from previously used Lissajous figure method. fact, we believe that more efficient...
It is a crucial premise for Fizeau interferometric imaging that all the optical axes of sub-apertures are well aligned. What challenging in tip/tilt alignment such interferometers superposition sub-aperture spots on focal plane generation fringes. In this paper, we propose and demonstrate simple scheme via defocus-based sub-spot separation (TADS). The interference function divided into sparse defocused sub-spots at long defocusing distance. Then servo-control technology with centroid...