A5090558909- Ubiquitin and proteasome pathways
- Cellular transport and secretion
- Endoplasmic Reticulum Stress and Disease
- Protein Degradation and Inhibitors
- Photosynthetic Processes and Mechanisms
- Mitochondrial Function and Pathology
- Multiple Myeloma Research and Treatments
- Autophagy in Disease and Therapy
- Fungal and yeast genetics research
- Protein Tyrosine Phosphatases
- Protein Kinase Regulation and GTPase Signaling
- Cellular Mechanics and Interactions
- Hippo pathway signaling and YAP/TAZ
- Cancer-related gene regulation
- Microtubule and mitosis dynamics
- Genomics, phytochemicals, and oxidative stress
- ATP Synthase and ATPases Research
- Click Chemistry and Applications
- Calcium signaling and nucleotide metabolism
- Redox biology and oxidative stress
- Heat shock proteins research
- Herpesvirus Infections and Treatments
- Erythrocyte Function and Pathophysiology
- Lipid Membrane Structure and Behavior
- Poxvirus research and outbreaks
Howard Hughes Medical Institute
2015-2024
University of California, Berkeley
2015-2022
Cornell University
2010-2016
Proteolysis-targeting chimeras (PROTACs), heterobifunctional compounds that consist of protein-targeting ligands linked to an E3 ligase recruiter, have arisen as a powerful therapeutic modality for targeted protein degradation (TPD). Despite the popularity TPD approaches in drug discovery, only small number recruiters are available >600 ligases exist human cells. Here, we discovered cysteine-reactive covalent ligand, EN106, targets FEM1B, recently critical component cellular response...
Although oxidative phosphorylation is best known for producing ATP, it also yields reactive oxygen species (ROS) as invariant byproducts. Depletion of ROS below their physiological levels, a phenomenon reductive stress, impedes cellular signaling and has been linked to cancer, diabetes, cardiomyopathy. Cells alleviate stress by ubiquitylating degrading the mitochondrial gatekeeper FNIP1, yet unknown how responsible E3 ligase CUL2FEM1B can bind its target based on redox state this adjusted...
Membrane lipid dynamics must be precisely regulated for normal cellular function, and disruptions in homeostasis are linked to the progression of several diseases. However, little is known about sensory mechanisms detecting membrane composition how metabolism response stress. We find that phosphoinositide (PI) kinase signaling controls a conserved PDK-TORC2-Akt cascade as part network allows endoplasmic reticulum (ER) modulate essential responses, including Ca 2+ -regulated biogenesis, upon...
Effector-triggered immunity (ETI) is a form of pathogen sensing that involves detection pathogen-encoded virulence factors or 'effectors'. To discover novel ETI pathways in mammals, we developed screening approach which individual are expressed human monocytes and transcriptional responses assessed by RNA-seq. Using this approach, identify poxvirus effector, myxoma virus M3.1, elicits an anti-viral NF-κB response. We find unleashed pathway senses M3.1 attack two complexes: ZAP TBK1....
Abstract Proteolysis Targeting Chimeras (PROTACs), heterobifunctional compounds that consist of protein-targeting ligands linked to an E3 ligase recruiter, have arisen as a powerful therapeutic modality for targeted protein degradation (TPD). Despite the popularity TPD approaches in drug discovery, only small number recruiters are available >600 ligases exist human cells. Here, we discovered cysteine-reactive covalent ligand, EN106, targets FEM1B, recently critical component cellular...
Information transfer between intracellular organelles must take place to regulate the size, shape, composition, and function of individual organelles, as well for normal cell growth development. The endoplasmic reticulum (ER) forms an expansive membrane network that contacts participates in crosstalk with several other cell, most notably plasma (PM). ER‐PM junctions have well‐established functions movement signaling molecules, such lipids ions, ER PM. However, little is known about...