A5033524731- Head and Neck Cancer Studies
- Oral health in cancer treatment
- Lung Cancer Treatments and Mutations
- Advanced Radiotherapy Techniques
- Cancer Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Medical Imaging Techniques and Applications
- Salivary Gland Tumors Diagnosis and Treatment
- Effects of Radiation Exposure
- Colorectal and Anal Carcinomas
- Growth Hormone and Insulin-like Growth Factors
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Thyroid Disorders and Treatments
- Dysphagia Assessment and Management
- Statistical Methods in Clinical Trials
- Erythropoietin and Anemia Treatment
- Pain Management and Opioid Use
- Radiation Therapy and Dosimetry
- Pain Mechanisms and Treatments
Skåne University Hospital
2014-2025
Lund University
2014-2025
Centre de Recherche en Cancérologie de Lyon
2019
University of Gothenburg
2000
We performed an open-label randomized controlled phase III study comparing treatment outcome and toxicity between radiotherapy (RT) with concomitant cisplatin versus cetuximab in patients locoregionally advanced head neck squamous cell carcinoma (HNSCC; stage III-IV according to the Union for International Cancer Control TNM classification, 7th edition).Eligible were randomly assigned 1:1 receive either intravenous 400 mg/m2 1 week before start of RT followed by 250 mg/m2/wk, or weekly 40...
There are indications that PRL may exert important metabolic actions on adipose tissue in different species. However, with the exception of birds, receptor has not been identified white tissue. The present study was designed to examine possible expression and regulation (PRLR) mouse long PRLR messenger RNA (mRNA) splice form (L-PRLR) two short forms (S2- S3-PRLR) were detected by RT-PCR. Furthermore, L-PRLR mRNA ribonuclease protection assay. Immunoreactive a relative molecular mass 95,000...
Circulating tumour (ct) human papillomavirus (HPV) DNA is detectable in HPV-related oropharyngeal carcinoma (OPSCC) patients and has the potential to become an important clinical tool. This study aimed evaluate prognostic significance of ctHPV16-DNA kinetics during treatment with chemoradiotherapy OPSCC. Patients p16-positive OPSCC recruited ARTSCAN III trial, comparing radiotherapy plus cisplatin cetuximab, constituted cohort.Blood samples before start at end 136 were analysed. was...
Introduction: Trismus is a treatment-related late side effect in patients treated for cancer the head and neck region (HNC). The condition can have considerable negative impact on nutrition, dental hygiene, ability to speak quality of life. We previously studied trismus within frame randomized phase 3 study HNC with mainly three-dimensional (3D) conformal radiotherapy (CRT) found strong association mean radiation dose mastication muscles, especially ipsilateral masseter muscle (iMAS). In...
Highlights•Daily imaging was used to assess adaptive radiotherapy for head and neck cancer.•Plan adaptation on synthetic CT deformed contours clinically feasible.•With 2 mm margin, 16/31 of patients 77/902 fractions needed plan adaptation.•Adaptation with smaller margins required reduced doses organs at risk.AbstractBackground PurposeAdaptive (ART) involves treatment re-planning based anatomical changes, which may improve target coverage sparing organs-at-risk (OARs). This study...
Abstract Background The prescribed radiation dose to patients with oropharyngeal squamous cell carcinoma (OPSCC) is standardized, even if the prognosis for individual may differ. Easy-at-hand pre-treatment risk stratification methods are valuable individualize therapy. In current study we assessed prognostic impact of primary tumor volume p16-positive and p16-negative tumors in relationship other factors outcome OPSCC treated therapy (RT). Methods Five hundred twenty-three p16-status RT...
Abstract Background A large tumor volume negatively impacts the outcome of radiation therapy (RT). Altered fractionation (AF) can improve local control (LC) compared with conventional (CF). The aim present study was to investigate if response AF differs in oropharyngeal cancer. Methods Three hundred and twenty four patients cancer treated a randomized, phase III trial comparing CF (2 Gy/d, 5 d/wk, 7 weeks, total dose 68 Gy) (1.1 Gy + 2 4.5 were analyzed. Results Tumor had less impact on LC...
Abstract Background This exploratory, registry‐based, cross‐sectional study aimed to evaluate patients' health‐related quality of life (HRQOL) in a subsite oropharyngeal cancer: cancer the base tongue (CBT). Methods CBT patients, treated with curative intent, completed EORTC QLQ‐C30 and QLQ‐H&N35 questionnaires 15 months after diagnosis. The HRQOL patients was compared reference scores from general population that tonsillar carcinoma patients. Results 190 scored significantly worse than...
Abstract Introduction Head and neck cancer of unknown primary (HNCUP) is a rare condition whose prognostic factors that are significant for survival vary between studies. No randomized treatment study has been performed thus far, the optimal not established. Objective The present aimed to explore various compare two main treatments HNCUP: dissection (chemo) radiation vs radiation. Methods A national multicenter was with data from Swedish Neck Cancer Register (SweHNCR) patients' medical...
Abstract Background The health‐related quality of life (HRQOL) tonsillar carcinoma survivors was explored to investigate any HRQOL differences associated with tumor stage and treatment. survivors' also compared reference scores from the population. Methods In this exploratory cross‐sectional study patients were invited 15 months after their diagnosis asked answer two questionnaires (EORTC QLQ‐ C30, EORTC HN35), 405 participated. Results gender, males scoring better than females on a few...
Background and purposeAn earlier prospective randomised multicentre study (ARTSCAN) in head neck cancer patients that compared conventionally fractionated radiotherapy (CF) with accelerated (AF) was inconclusive. In the subgroup of oral cavity squamous cell (OCSCC) a large absolute, but not statistically significant, difference local control seen favour AF. This more pronounced resectable tumours. The finding raised hypothesis AF could be beneficial for OCSCC patients. addition, longstanding...
Several studies on the use of erythropoietin (Epo) to treat anaemia in patients undergoing cancer treatment have shown adverse effects tumour control and survival. Experimental indicate that this could be linked an interaction with wound healing processes not effect cells per se. We previously combination surgical trauma stimulates growth. In present study, we investigated surgery Epo gene expression. Human tumours from oral squamous cell were xenotransplanted nude mice treated Epo. The then...
The purpose of this study was to compare complication rates at the mandibulotomy site between patients receiving preoperative radiotherapy (RT) and those postoperative RT during treatment for oral oropharyngeal cancer where surgical procedure required a mandibular osteotomy gain access tumour. Sixty-four consecutive treated period 2000–2015 were available analysis. Their medical records reviewed retrospectively. All followed least 1 year postoperatively. A subgroup received on several...
Analyses of clinical outcomes following radiotherapy (RT) have advanced our understanding fundamental radiobiological characteristics in head and neck squamous cell carcinoma (HNSCC). Low fractionation sensitivity appears to be a common feature, as well susceptibility changes overall treatment time (OTT). Large tumors should harder cure if successful RT requires the sterilization all clonogenic cells. Congruently, primary tumor volume has proven an important parameter. However, most findings...
All Nordic countries have national cancer registries collecting data on head and neck (HNC) incidence survival. However, there is a lack of consensus how other quality aspects should be monitored.
Objectives: This study aimed to describe the clinical experience of health-care professionals (HCPs) responsible for introduction methadone, treatment complex cancer pain, at a low-resource hospital in India patient-group, burdened by illiteracy, and low socio-economic status. Materials Methods: Ten HCPs: Four medical doctors, four nurses, one pharmacist, administrator were interviewed. The interviews are examined using qualitative conventional content analysis. Results: showed confidence...