A5036048718- Immune cells in cancer
- Zebrafish Biomedical Research Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Amyotrophic Lateral Sclerosis Research
- Autophagy in Disease and Therapy
- Phagocytosis and Immune Regulation
- Aquaculture disease management and microbiota
- Single-cell and spatial transcriptomics
- Nerve injury and regeneration
- Amino Acid Enzymes and Metabolism
- Pluripotent Stem Cells Research
- ATP Synthase and ATPases Research
- Neurogenetic and Muscular Disorders Research
- Barrier Structure and Function Studies
- Adenosine and Purinergic Signaling
- RNA Research and Splicing
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Centre National de la Recherche Scientifique
2013-2024
Inserm
2017-2024
Université Paris Cité
2020-2024
Institut des Maladies Génétiques Imagine
2024
Institut Pasteur
2013-2024
Biologie du Développement et Cellules Souches
2013-2024
Sorbonne Université
2017-2020
Institut du Cerveau
2017-2020
Hôpital Necker-Enfants Malades
2020
Laboratoire de Recherche Scientifique
2013
Microglia are specialized macrophages responsible for the clearance of dead neurons and pathogens by phagocytosis degradation. The degradation requires phagosome maturation acidification provided vesicular- or vacuolar-type H+-translocating adenosine triphosphatase (V-ATPase), which is composed cytoplasmic V1 domain membrane-embedded Vo domain. V-ATPase a subunit, an integral part domain, has four isoforms in mammals. functions different on cells/species remain controversial. Here we show...
ABSTRACT Macrophages infiltrate and establish in developing organs from an early stage, often before these have become vascularized. Similarly, leukocytes, general, can quickly migrate through tissues to any site of wounding. This unique capacity is rooted their characteristic amoeboid motility, the genetic basis which poorly understood. Trim33 (also known as Tif1-γ), a nuclear protein that associates with specific DNA-binding transcription factors modulate gene expression, has been found be...
The GGGGCC hexanucleotide repeat expansion (HRE) of the
ABSTRACT Most tissues harbor a substantial population of resident macrophages. Here, we elucidate functional link between the Slc7a7 cationic amino acid transporter and tissue We identified mutant zebrafish devoid microglia due to mutation in slc7a7 gene. found that Slc7a7-deficient larvae, macrophages do enter retina brain become microglia, but then die during developmental wave neuronal apoptosis, which triggers intense efferocytic work from them. A similar macrophage demise occurs other...
Neurofilaments (NFs), a major cytoskeletal component of motor neurons, play key role in the differentiation, establishment and maintenance their morphology mechanical strength. The de novo assembly these neuronal intermediate filaments requires presence neurofilament light subunit (NEFL), whose expression is reduced neurons amyotrophic lateral sclerosis (ALS). This study used zebrafish as model to characterize NEFL homologue neflb, which encodes two different isoforms via splicing primary...
Trim33 (Tif1γ) is a transcriptional regulator that notably involved in several aspects of hematopoiesis. It essential for the production erythrocytes zebrafish, and proper functioning aging hematopoietic stem progenitor cells (HSPCs) mice. Here, we have found that, zebrafish development, cell-autonomously lifespan yolk sac-derived primitive macrophages, as well initial definitive (HSPC-derived) macrophages first niche hematopoiesis, caudal tissue. Moreover, deficiency leads to an excess...
ABSTRACT Most tissues harbor a substantial population of resident macrophages. It is not quite known yet how their diverse phenotypes are shaped by the functions that they assume in each tissue. In this study, we elucidate functional link between Slc7a7 cationic amino acid transporter and tissue We had identified mutant zebrafish devoid microglia due to mutation slc7a7 gene. found deficient larvae, macrophages do enter retina brain become microglia, but then die during developmental wave...
ABSTRACT TRIM33 (Tif1-γ) is a transcriptional regulator notably involved in several aspects of hematopoiesis. It essential for the production erythrocytes zebrafish, and proper functionning aging hematopoietic stem progenitor cells (HSPCs) mice. Here we have found that zebrafish development, Trim33 cell-autonomously lifespan yolk sac derived primitive macrophages, as well initial definitive (HSPC-derived) macrophages first niche hematopoiesis, caudal tissue. Moreover, deficiency leads to an...