A5103177200- Intracranial Aneurysms: Treatment and Complications
- Liver Disease Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Pulmonary Hypertension Research and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Liver Disease and Transplantation
- Hippo pathway signaling and YAP/TAZ
- Cancer-related molecular mechanisms research
- Fetal and Pediatric Neurological Disorders
- Signaling Pathways in Disease
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer, Lipids, and Metabolism
- Viral Infections and Immunology Research
- Autophagy in Disease and Therapy
- Drug Transport and Resistance Mechanisms
- Muscle Physiology and Disorders
- Lung Cancer Research Studies
- Vascular Malformations Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Gestational Diabetes Research and Management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Head and Neck Surgical Oncology
- Deception detection and forensic psychology
- Cervical and Thoracic Myelopathy
Xuzhou Medical College
2023-2025
Brigham and Women's Hospital
2024-2025
Harvard University
2024-2025
Sichuan University
2017-2024
Shandong Provincial Hospital
2024
Shandong First Medical University
2024
Shanghai Clinical Research Center
2024
Sichuan Tourism University
2023-2024
Capital Medical University
2021-2024
Beijing Chao-Yang Hospital
2021-2024
Summary Background Previous studies have demonstrated an association between nonselective beta‐blockers (NSBBs) and lower risk of hepatocellular carcinoma (HCC) in cirrhosis. However, there has been no population‐based study investigating the HCC among cirrhotic patients treated using carvedilol. Aims To determine with NSBBs including Methods This retrospective cohort utilised Cerner Health Facts database United States from 2000 to 2017. Kaplan‐Meier estimate, Cox proportional hazards...
As machine learning is becoming the fashion in disease prediction while no model has performed very efficiently and accurately on predicting pregnancy diseases up to now, it's necessary compare several common methods' performance select out best one. The data of two complications, pregnancy-induced hypertension (PIH) Intrahepatic cholestasis (ICP), based various maternal characteristics measured patients' routine blood examination 10-19 weeks gestation are considered be suitable learned....
Objectives: DS-6157a is a first-in-class antibody–drug conjugate (ADC) that targets G protein-coupled receptor 20 (GPR20) and comprises humanized anti-GPR20 monoclonal antibody covalently conjugated to an enzyme-cleavable linker, topoisomerase I inhibitor payload (DXd, also known as MAAA-1181a) at drug-to-antibody ratio of ~8. We aimed characterize the pharmacokinetics (PK) (intact ADC) DXd (released payload) through development population PK (PopPK) model evaluate exposure–response (ER)...
Abstract Background: Social determinants of health (SDOH) are crucial in shaping outcomes, yet comprehensive studies that span all key SDOH domains (economic stability, education, healthcare access and quality, neighborhood built environment, social community context) to examine their associations with liver cancer risk sparse. We developed validated a Determinants Disadvantage Score (SDDS) address this knowledge gap. Methods: conducted cross-sectional analysis 117, 783 participants from the...
An increased neutrophil-to-lymphocyte ratio (NLR) is associated with poorer prognostic outcomes in numerous types of cancer. However, a small number studies have demonstrated the role NLR patients laryngeal The present study evaluated association between and survival squamous All were scheduled for follow-up visits. levels cytokines from tumor tissues analyzed by ELISA. A classification regression tree (CART) was used to determine optimal cutoff values NLR. clinical features determined using...
Oxidative stress and metabolic disorders are involved in the pathogenesis of polycystic ovary syndrome (PCOS). Heme oxygenase 2 (HMOX2) plays a critical role preserving heme metabolism as well modulating glycolipid metabolism, oxidative stress, inflammation. This study examined correlation between HMOX2 G554A (rs1051308) A-42G (rs2270363) genetic variants with risk PCOS assessed effects these genotypes on clinical, hormonal, metabolic, indices using case–control design that included 1014...
Balloon pulmonary angioplasty (BPA) is an established treatment for inoperable chronic thromboembolic hypertension (CTEPH), but its efficacy in CTEPH patients with a comorbidity has not been well-studied. Here, we compared post-BPA outcomes between and without disease at baseline analyzed predictors of BPA success. From August 2017 to October 2022, 62 who underwent were consecutively enrolled grouped based on the presence baseline. All transthoracic echocardiography, function tests, right...
Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disease associated with significant risk fetal complications including pre-term delivery and death. Typically, it was diagnosed in the third trimester pregnancy. This study utilized characteristics from routine maternal examinations first 20 weeks' gestation to predict ICP pregnant women.This retrospective case-control study. 13,329 medical records were collected on women presenting West China Second University...
Alpha-calcitonin gene-related peptide (αCGRP) plays a significant pathophysiological role in the regulation of bone metabolism. Our previous research indicated that αCGRP might have potential application enhancing osseointegration vivo. To further uncover intrinsic mechanism its networks regeneration, here we investigate impact on osteogenic differentiation marrow-derived mesenchymal stem cells (BMSCs) from both wild-type and -/- mice. Considering half-life plasma is only 10 min, applied...
ABSTRACTDrawing upon presence theory, this study seeks to unravel the critical determinants converting engagement into value cocreation in travel livestreaming. To configure an optimal path for real-time interaction, live room setting, and product attributes livestreaming via viewers' sense of presence, we performed a scenario-based quasi-experiment with four alternative models. Model 1 elucidated direct influence mechanism how authenticity, remuneration evoke cocreation, while 2 reflected...
Abstract Human periodontal ligament cells (hPDLCs) are considered as an ideal cell type for tissue engineering hPDLCs own mesenchymal stem cell‐like properties. Additionally, it is suggested that α‐calcitonin gene‐related peptide (αCGRP) plays a pivotal role in the pathogenesis of periodontitis. However, specific αCGRP on regulation alveolar bone regeneration which essential treatment periodontitis remains unclear. In this study, lentiviral expression vector was first transfected into...
Background: Right ventricular (RV) function plays a vital role in the prognosis of patients with chronic thromboembolic pulmonary hypertension (CTEPH). We used new machine learning (ML)-based fully automated software to quantify RV using three-dimensional echocardiography (3DE) predict adverse clinical outcomes CTEPH patients. Methods: A total 151 consecutive were registered this prospective study between April 2015 and July 2019. New ML-based methods for data management, quantitative...
Purpose This study aimed to investigate the associations between hemoglobin (HGB) levels and bone mineral density (BMD) fracture risk in type 2 diabetes mellitus(T2DM) population of different ages. Method cross-sectional included 641 patients with T2DM (57.9% males). BMD femoral neck (FN), total hip (TH), lumbar spine (LS) were measured using dual-energy X-ray absorptiometry. The 10-year probability was assessed a assessment tool (FRAX). HGB other biochemical indices certified laboratory at...