A5023999680- Sirtuins and Resveratrol in Medicine
- Cancer Mechanisms and Therapy
- PARP inhibition in cancer therapy
- Autophagy in Disease and Therapy
- Peptidase Inhibition and Analysis
- Glaucoma and retinal disorders
- Adipose Tissue and Metabolism
- Microtubule and mitosis dynamics
- Hippo pathway signaling and YAP/TAZ
- Renal and related cancers
- Corneal surgery and disorders
- Developmental Biology and Gene Regulation
- Cancer-related Molecular Pathways
- Antioxidant Activity and Oxidative Stress
- Mitochondrial Function and Pathology
- Reproductive System and Pregnancy
- Synthesis and bioactivity of alkaloids
- Ovarian cancer diagnosis and treatment
- Biological Research and Disease Studies
- Advanced Breast Cancer Therapies
- Glioma Diagnosis and Treatment
- RNA modifications and cancer
- FOXO transcription factor regulation
- Cancer Cells and Metastasis
- Histone Deacetylase Inhibitors Research
Consejo Superior de Investigaciones Científicas
2016-2021
Instituto de Biomedicina de Sevilla
2015-2021
Universidad de Sevilla
2015-2021
Instituto de Salud Carlos III
2017-2021
Centro de Investigación Biomédica en Red
2021
Hospital Universitario Virgen del Rocío
2015-2021
Centro de Investigación Biomédica en Red de Cáncer
2017-2020
Universidad de Málaga
2013-2014
University of Łódź
2013
Abstract Purpose: Colorectal cancer is the second most common in women and third men worldwide. However, despite current progress, many patients with advanced metastatic tumors still die from malignancy. Refractory disease often relies on nicotinamide adenine dinucleotide (NAD)-dependent mechanisms. NAD metabolism a stable regeneration circuit are required to maintain tissue homeostasis metabolism. high levels of confer therapy resistance tumors. Experimental Design: Ectopic overexpression...
Ovarian cancer is one of the most common and malignant cancers, partly due to its late diagnosis high recurrence. Chemotherapy resistance has been linked poor prognosis believed be stem cell (CSC) pool. Therefore, elucidating molecular mechanisms mediating therapy essential finding new targets for therapy-resistant tumors.shRNA depletion MYPT1 in ovarian lines, miRNA overexpression, RT-qPCR analysis, patient tumor samples, line- tumorsphere-derived xenografts, vitro vivo treatments, analysis...
// Antonio Lucena-Cacace 1, 2 , Daniel Otero-Albiol Manuel P. Jiménez-García Javier Peinado-Serrano 1 and Amancio Carnero Instituto de Biomedicina Sevilla, IBIS, Hospital Universitario Virgen del Rocio, Universidad Consejo Superior Investigaciones Cientificas, Spain CIBER DE CANCER, Salud Carlos III, Madrid, Correspondence to: Carnero, email: acarnero-ibis@us.es Keywords: NAMPT, cancer initiating cell, gene signature, glioma, glioblastoma Received: June 22, 2017 Accepted: July 25, Published:...
Sarcomas are malignant tumors accounting for a high percentage of cancer morbidity and mortality in children young adults. Surgery radiation therapy the accepted treatments most sarcomas; however, patients with metastatic disease treated systemic chemotherapy. Many display marginal levels chemoresponsiveness new treatment approaches needed. Deregulation G1 checkpoint is crucial various oncogenic transformation processes, suggesting that many cell types depend on CDK4/6 activity. Thus,...
Ovarian cancer is the leading cause of gynecologic cancer-related death, due in part to a late diagnosis and high rate recurrence. Primary acquired platinum resistance related low response probability subsequent lines treatment poor survival. Therefore, comprehensive understanding mechanisms that drive urgently needed.We used bioinformatics analysis public databases RT-qPCR quantitate relative gene expression profiles ovarian tumors. Many dysregulated genes were stem cell (CSC) factors, we...
Abstract The PIM family of serine/threonine kinases has three highly conserved isoforms (PIM1, PIM2 and PIM3). proteins are regulated through transcription stability by JAK/STAT pathways overexpressed in hematological malignancies solid tumors. possess weak oncogenic abilities, but enhance other genes or chemical carcinogens to induce We generated conditional transgenic mice that overexpress PIM1 male reproductive organs analyzed their contribution tumorigenesis. found an increase...
// Manuel-Pedro Jiménez-García 1 , Antonio Lucena-Cacace María-José Robles-Frías Irene Ferrer Maja Narlik-Grassow 2 Carmen Blanco-Aparicio and Amancio Carnero 1, 3 Instituto de Biomedicina Sevilla, IBIS, Hospital Universitario Virgen del Rocío, Universidad Consejo Superior Investigaciones Científicas, Seville, Spain Experimental Therapeutics Programme, Spanish National Cancer Centre (CNIO), Madrid, CIBER Cáncer, Salud Carlos III, Pabellón 11, Planta 0, Correspondence to: Carnero, email:...
Oxidative stress may play a role in the pathogenesis of keratoconus (KC) and Fuchs endothelial corneal dystrophy (FECD). Iron promote by Fenton reaction, so its homeostasis should be strictly controlled. Transferrin is essential for iron because it transports from plasma into cells. The malfunction transferrin, which caused variation gene (TF) variation, contribute to oxidative change KC FECD risk. To verify this hypothesis we investigated association between three polymorphisms TF gene,...
The EMX (Empty Spiracles Homeobox) genes EMX1 and EMX2 are two homeodomain gene members of the family transcription factors involved in regulation various biological processes, such as cell proliferation, migration, differentiation, during brain development neural crest migration. They play a role specification positional identity, proliferation stem cells, differentiation certain neuronal phenotypes. In general, they act early embryogenesis neuroembryogenesis from metazoans to higher...
Sarcomas are a very heterogeneous group of tumors with intrinsic developmental programs derived from the cell origin. This implies functional hierarchy inside governed by sarcoma stem cells. Therefore, genetic and/or epigenetic changes profoundly affect biology tumor EMX genes proposed to be transcription factors that involved in sarcomagenesis process, regardless neural or mesodermal embryological It has been shown EMX1 EMX2 overexpression reduces tumorigenic properties, while reducing...
Gliomas are highly metabolically active tumors. Cancer metabolism is currently of great interest to researchers. Nicotinamide adenine dinucleotide (NAD) central in cell metabolism. NAD+ plays a crucial role wide spectrum metabolic processes the cancer metabolism, boosting and feeding enzymes as cofactor, an important driver reprograming. biology goes through most essential pathways helping derive energy multiple ways, depicting one metabolites maintain cellular homeostasis. Understanding its...
Introduction In recent years, the molecular mechanisms involved in development of ovary tumours have been studied, although little is known about high resistance these to conventional therapies. We found that expression myosin phosphatase-targeting subunit 1 (MYPT1), which has related cancer progression, tumour samples versus normal tissues was reduced, as also overall survival patients. MYPT1 a regulator protein phosphatase (PP1C), play critical roles controlling phosphorylation states...
Abstract Background. PIM proteins belong to a family of ser/thr kinases composed 3 members, PIM1, 2 and 3, with overlapping functions mainly regulated by pathways controlled JAK/STAT transcription factors. The have been implicated in the regulation apoptosis, metabolism, cell cycle, homing migration, they found be overexpressed many sort tumors, therefore these are interesting targets for anticancer drug therapy. Although identified as oncogenes transgenic models, weak transforming abilities...
<p>Figure S1: Overall survival probability of the patients according to NAMPT levels segregated by colon cancer stage. Figure S2. Tumorigenic properties induces S3. Effect a second shRNA against in tumorigenic capability tumor cells. S4. CD133+ single cell derived tumorspheres HCT116. S5.Tumorigenic capabilities NAMPT-dependent HCT 116 +/+ p53 wild type. S6. (A) GSE34053 database, from human tumors, have transcription profiles sorted We analyzed correlation cells with expression along...
<p>Figure S1: Overall survival probability of the patients according to NAMPT levels segregated by colon cancer stage. Figure S2. Tumorigenic properties induces S3. Effect a second shRNA against in tumorigenic capability tumor cells. S4. CD133+ single cell derived tumorspheres HCT116. S5.Tumorigenic capabilities NAMPT-dependent HCT 116 +/+ p53 wild type. S6. (A) GSE34053 database, from human tumors, have transcription profiles sorted We analyzed correlation cells with expression along...
<div>Abstract<p><b>Purpose:</b> Colorectal cancer is the second most common in women and third men worldwide. However, despite current progress, many patients with advanced metastatic tumors still die from malignancy. Refractory disease often relies on nicotinamide adenine dinucleotide (NAD)-dependent mechanisms. NAD metabolism a stable regeneration circuit are required to maintain tissue homeostasis metabolism. high levels of confer therapy resistance...
<div>Abstract<p><b>Purpose:</b> Colorectal cancer is the second most common in women and third men worldwide. However, despite current progress, many patients with advanced metastatic tumors still die from malignancy. Refractory disease often relies on nicotinamide adenine dinucleotide (NAD)-dependent mechanisms. NAD metabolism a stable regeneration circuit are required to maintain tissue homeostasis metabolism. high levels of confer therapy resistance...