A5024585211- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Enzyme Structure and Function
- Cellular transport and secretion
- Genetic and phenotypic traits in livestock
- Calcium signaling and nucleotide metabolism
- Muscle Physiology and Disorders
- Genetic diversity and population structure
- Epigenetics and DNA Methylation
- Phagocytosis and Immune Regulation
- Livestock and Poultry Management
- Neonatal Respiratory Health Research
- Advanced Glycation End Products research
- Genetic Mapping and Diversity in Plants and Animals
- Alzheimer's disease research and treatments
- MicroRNA in disease regulation
- Identification and Quantification in Food
- Insect Utilization and Effects
- Pneumonia and Respiratory Infections
- Molecular Biology Techniques and Applications
- Birth, Development, and Health
- Agricultural Economics and Practices
- Circular RNAs in diseases
- RNA regulation and disease
- Bacterial Infections and Vaccines
University of New Mexico
2021-2025
Guangzhou Medical University
2016-2020
Guangzhou Women and Children Medical Center
2016-2019
Huazhong Agricultural University
2014-2016
National Bureau of Animal Genetic Resources
2010-2011
Kurukshetra University
2011
Island Hospital
2007
ATG5 is one of the core autophagy proteins with additional functions such as noncanonical membrane atg8ylation, which among a growing number biological outputs includes control tuberculosis in animal models. Here, we show that associates retromer’s components VPS26, VPS29, and VPS35 modulates retromer function. Knockout blocked trafficking key glucose transporter sorted by retromer, GLUT1, to plasma membrane. Knockouts other genes essential for component, affected GLUT1 sorting, indicating...
Canonical autophagy captures within specialized double-membrane organelles, termed autophagosomes, an array of cytoplasmic components destined for lysosomal degradation. An autophagosome is completed when the growing phagophore undergoes ESCRT-dependent membrane closure, a prerequisite its subsequent fusion with endolysosomal organelles and degradation sequestered cargo. ATG9A, key integral protein pathway, best known role in formation expansion phagophores. Here, we report hitherto...
We report that lysosomal damage is a hitherto unknown inducer of stress granule (SG) formation and the process termed membrane atg8ylation coordinates SG with mTOR inactivation during stress. SGs were induced by lysosome-damaging agents including SARS-CoV-2ORF3a, Mycobacterium tuberculosis, proteopathic tau. During damage, mammalian ATG8s directly interacted core proteins NUFIP2 G3BP1. Atg8ylation was needed for their recruitment to damaged lysosomes independently condensates whereupon...
Abstract Background Smoking leads to the aging of organs. However, no studies have been conducted quantify effect smoking on respiratory organs and aging-reversing ability cessation. Results We collected genome-wide methylation datasets buccal cells, airway esophagus tissue, lung tissue from non-smokers, smokers, ex-smokers. used “epigenetic clock” method epigenetic age acceleration in four The statistical analyses showed following: (1) increased cells by an average 4.9 years 4.3 years. (2)...
Knowing the biological age of neonates enables us to evaluate and better understand health maturity comprehensively. However, because dearth biomarkers, it is difficult quantify neonatal age. Here we sought assess variability in at birth how aging rates before are influenced by exposure intrauterine period employing a novel epigenetic biomarker (epigenetic clock). We observed that methylation was independent infant's sex but significantly race. Partial correlation analysis showed significant...
The functions of mammalian Atg8 proteins (mATG8s) expand beyond canonical autophagy and include processes collectively referred to as Atg8ylation. Global modulation protein synthesis under stress conditions is governed by MTOR liquid-liquid phase separated condensates containing ribonucleoprotein particles known granules (SGs). We report that lysosomal damage induces SGs acting a hitherto unappreciated inhibitor translation via EIF2A/eIF2α phosphorylation while favoring an ATF4-dependent...
MicroRNAs (miRNAs) play an imperative role in cell proliferation, differentiation, and metabolism through regulation of gene expression. Skeletal muscle hypertrophy that results from myostatin depression by its propeptide provides interesting model to understand how miRNA transcriptome is involved myostatin-based fiber hypertrophy. This study employed Solexa deep sequencing followed Q-PCR methods analyze skeletal transgenic mice comparison with their littermate controls. A total 461 mature...
ATG5 plays a pivotal role in membrane Atg8ylation, influencing downstream processes encompassing canonical autophagy and noncanonical processes. Remarkably, genetic ablation of myeloid cells leads to an exacerbated pathological state murine models tuberculosis, characterized by early surge mortality much more severe when compared the depletion other components involved Atg8ylation or autophagy. This study shows that absence ATG5, but not core factors, endolysosomal organelles display...
ATG5 is one of the core autophagy proteins with additional functions such as noncanonical membrane atg8ylation, which among a growing number biological outputs includes control tuberculosis in animal models. Here, we show that associates retromer’s components VPS26, VPS29, and VPS35 modulates retromer function. Knockout blocked trafficking key glucose transporter sorted by retromer, GLUT1, to plasma membrane. Knockouts other genes essential for component, affected GLUT1 sorting, indicating...
Now-a-days processed and canned food products are consumed in increasing quantity all developing developed countries following changes human lifestyle. However, customers often fooled by they buy such frauds frequently go unreported since species identification requires technical inputs considerable time efforts. We bought two meat packets labelled as 'classic delicious deer meat' from Shanghai Pudong International Airport, (People's Republic of China) to understand its origin is legally...
Single Nucleotide Polymorphisms (SNPs) are the most frequent form of DNA variation in genome. SNPs genetic markers which bi-allelic nature and grow at a very fast rate. Current genomic databases contain information on several million SNPs. More than 6 have been identified is publicly available through efforts SNP Consortium others data bases. The NCBI plays major role facillating identification cataloging creation maintenance public database (dbSNP) by biomedical community worldwide...
More than 40 million households in India depend at least partially on livestock production. Buffaloes are one of the major milk producers India. The prolactin receptor (PRLR) gene and peroxisome proliferators activated receptor-γ coactivator 1-alpha (PPARGC1A) reportedly associated with protein fat yields Bos taurus. In this study, we sequenced PRLR PPARGC1A genes water buffalo Bubalus bubalis. coded for 581 819 amino acids, respectively. B. bubalis differed from corresponding taurus 21...
Identification of the candidate genes that play key roles in phenotypic variations can provide new information about evolution and positive selection. Interleukin (IL)-32 is involved many biological processes, however, its role for immune response against various diseases mammals poorly understood. Therefore, current investigation was performed better understanding molecular selection single nucleotide polymorphisms IL-32 gene.By using fixation index (FST ) based method, (9375) gene found to...
When setting-up a captive population, genetic assessment of founders is essential to formulate effective breeding strategies that minimize the negative effects inbreeding in successive generations caused by mating between genetically related individuals. We carried out molecular analysis Cheer Pheasant and Western Tragopan populations Chail Sarahan Pheasantries State Himachal Pradesh. The results revealed stock sustaining well does not exhibit signatures inbreeding. Conversely, strongly...
Prolactin receptor (PRLR) and Peroxisome Proliferator Receptor Gamma Coactivator 1 Alpha (PPARGC1A) are candidate genes associated with milk protein fat yield in dairy cattle. These were sequence characterized to identify exonic SNPs water buffalo (Bubalus bubalis). Six novel specific identified PCR-RFLP loci for these developed validated. can effectively be used genotyping PRLR PPARGC1A recorded population association studies yield. Key words: Bubalus bubalis, PRLR gene, PCR-RFLP,...
ABSTRACT ATG5 is one of the core autophagy proteins with additional functions such as noncanonical membrane atg8ylation, which among a growing number biological outputs includes control tuberculosis in animal models. Here we show that associates retromer’s components VPS26, VPS29 and VPS35 modulates retromer function. Knockout blocked trafficking key glucose transporter sorted by retromer, GLUT1, to plasma membrane. Knockouts other genes essential for component, affected GLUT1 sorting,...