A5102368394- Cell death mechanisms and regulation
- DNA Repair Mechanisms
- 14-3-3 protein interactions
- 3D IC and TSV technologies
- Cancer-related Molecular Pathways
- Interconnection Networks and Systems
- Biological Research and Disease Studies
- Gear and Bearing Dynamics Analysis
- Photonic and Optical Devices
- Thermochemical Biomass Conversion Processes
- Escherichia coli research studies
- ATP Synthase and ATPases Research
- Histone Deacetylase Inhibitors Research
- Tribology and Lubrication Engineering
- Ubiquitin and proteasome pathways
- VLSI and Analog Circuit Testing
- Genomics, phytochemicals, and oxidative stress
- Lignin and Wood Chemistry
- Advanced Measurement and Metrology Techniques
- MicroRNA in disease regulation
- Protein Degradation and Inhibitors
- Advanced biosensing and bioanalysis techniques
- Copper Interconnects and Reliability
- HIV/AIDS drug development and treatment
- Viral gastroenteritis research and epidemiology
Shanghai Jiao Tong University
2023-2025
Commercial Aircraft Corporation of China (China)
2023
Institute of Semiconductors
2023
Indiana University School of Medicine
2023
Chinese Academy of Sciences
2023
East China University of Science and Technology
2023
Indiana University – Purdue University Indianapolis
2023
University of Toledo
2022
Abstract Survivin, the smallest member of Inhibitor Apoptosis Protein (IAP) family, forms homodimers and coordinates with other IAPs to inhibit apoptosis by suppressing pro-apoptotic caspase 3/9 activation, contributing drug resistance. Due its overexpression in cancer cells lack expression normal adult tissues, survivin is an attractive target. However, developing survivin-selective inhibitors has been challenging due absence suitable active sites for targeting. Strategies have pursued...
Hybrid Bonding (HB) process has gradually become the primary choice of advanced packaging in processor-memory heterogeneous stacking scenarios with its huge advantages high interconnection density and low power consumption. However, enormous disparity between bandwidth upper bound processors extremely HB results resource usage robustness. In this paper, we propose a 3D interconnect design method "Multi-Bond Attach" (MBA) to improve bonding resources utilization reliability during chip...
<div>Abstract<p>Many oncoproteins are considered undruggable because they lack enzymatic activities. In this study, we present a small-molecule–based anticancer agent that acts by inhibiting dimerization of the oncoprotein survivin, thereby promoting its degradation along with spontaneous apoptosis in cancer cells. Through combination computational analysis interface and <i>in silico</i> screening, identified one compound induced proteasome-dependent survivin...
<div>Abstract<p>Many oncoproteins are considered undruggable because they lack enzymatic activities. In this study, we present a small-molecule–based anticancer agent that acts by inhibiting dimerization of the oncoprotein survivin, thereby promoting its degradation along with spontaneous apoptosis in cancer cells. Through combination computational analysis interface and <i>in silico</i> screening, identified one compound induced proteasome-dependent survivin...
<p>Effect of compounds from in-silico screening on cancer cell survival.</p>
<p>Effect of compounds from in-silico screening on cancer cell survival.</p>
<p>Supplemental Table S1. Sequence of shRNAs and siRNAs. Supplemental S2. Sequences primers for real time RT-PCR.</p>
<p>Supplemental Table S1. Sequence of shRNAs and siRNAs. Supplemental S2. Sequences primers for real time RT-PCR.</p>
<p>Figure S1. 14-3-3σ contributes to IR resistance. Figure S2. resistance in H1299 cells. S3. modulates IR-induced γ-H2AX S4. promotes NHEJ but not HR repair of DSBs. S5. Role PARP1 DNA-PKcs recruitment. S6. regulation Chk2 expression S7. regulates vice versa.</p>
<p>Figure S1. 14-3-3σ contributes to IR resistance. Figure S2. resistance in H1299 cells. S3. modulates IR-induced γ-H2AX S4. promotes NHEJ but not HR repair of DSBs. S5. Role PARP1 DNA-PKcs recruitment. S6. regulation Chk2 expression S7. regulates vice versa.</p>
Abstract In order to investigate the thermal variations of axial static stiffness motorized spindle unit, a modeling method is established by combining numerical simulation technology with analytical method. Firstly, based on thermoelastic ring cylinder model and Hertz contact theory, temperature rise - variation effect spindle-angular ball bearing system constructed; then, structural considering its coolant heat transfer obtained using finite element heat-fluid-solid coupling technology,...
The explosive growth of the data-intensive AI computing demands for datacenter interconnects with ever-increasing bandwidth (BW). Traditional pluggable optical modules can hardly meet DC power and form-factor requirements by new 51.2T ethernet switch. By tightly integrating compact engine (OE) into switch package, on-board metal traces are mostly replaced fiber, which thereby saves signaling improves front-panel BW-density. Depicted in Fig. 1(a), each 3.2T OE employs 4 quad-lane transceivers...
In the post-Moore era, chiplet heterogeneous integration technology is gaining attention as a way to address scaling limitations of monolithic chips. The Universal Chiplet Interconnect Express (UCIe) standard defines complete stack for inter-chiplet communication, ensuring interoperability among chiplets. This paper introduces MUG5, UCIe link model that enables accurate latency estimation through gem5-based simulation. targeted mode operation in PCIe 6.0 with 256B flit (flow control unit)....
<div>Abstract<p>Platinum-based concurrent chemoradiotherapy is considered a standard treatment approach for locoregionally advanced nasopharyngeal carcinoma. However, only minority of patients benefit from this regimen compared with radiotherapy alone. Identification set molecular markers predicting sensitivity platinum-based chemotherapy may contribute to personalized carcinoma better clinical outcome less toxicity. Previously, we generated cisplatin-sensitive cell line, S16, by...
<div>Abstract<p>14-3-3σ has been implicated in the development of chemo and radiation resistance poor prognosis multiple human cancers. While it postulated that 14-3-3σ contributes to these resistances via inhibiting apoptosis arresting cells G<sub>2</sub>–M phase cell cycle, molecular basis this regulation is currently unknown. In study, we tested hypothesis causes DNA-damaging treatments by enhancing DNA repair arrested following treatments. We showed contributed...