A5028463597- Photoacoustic and Ultrasonic Imaging
- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- Optical Imaging and Spectroscopy Techniques
- Non-Invasive Vital Sign Monitoring
- Hemodynamic Monitoring and Therapy
- Cell Image Analysis Techniques
- Thermoregulation and physiological responses
- Body Composition Measurement Techniques
- Advanced Chemical Sensor Technologies
- Analytical Chemistry and Sensors
- Microbial Inactivation Methods
- Listeria monocytogenes in Food Safety
- Bioinformatics and Genomic Networks
- Spectroscopy Techniques in Biomedical and Chemical Research
- Optical Coherence Tomography Applications
- Genetics, Bioinformatics, and Biomedical Research
- Electrical and Bioimpedance Tomography
Technical University of Munich
2018-2021
Helmholtz Zentrum München
2018-2021
The University of Texas MD Anderson Cancer Center
2019
DKFZ-ZMBH Alliance
2019
German Cancer Research Center
2019
Tel Aviv University
2016
Consorci d’Atenció Primària de Salut Barcelona Esquerra
2004
Respiratory motion in living organisms is known to result image blurring and loss of resolution, chiefly due the lengthy acquisition times corresponding methods. Optoacoustic tomography can effectively eliminate vivo artifacts its inherent capacity for collecting data from entire imaged region following a single nanoseconds-duration laser pulse. However, multi-frame analysis often essential applications relying on spectroscopic or scanning-based systems. Thereby, efficient methods correct...
Abstract Tracking of biodynamics across entire living organisms is essential for understanding complex biology and disease progression. The presently available small‐animal functional molecular imaging modalities remain constrained by factors including long image acquisition times, low spatial resolution, limited penetration or poor contrast. Here flash scanning volumetric optoacoustic tomography (fSVOT), a new approach high‐speed fast kinetics biodistribution optical contrast agents in...
Adequate capillary blood flow is a critical parameter for tissue vitality. We present novel non-invasive method measuring based on the acousto-optic effect, using ultrasound modulated diffused light. The benefits of presented are: deep sampling (> 1cm), continuous real time measurement, simplicity apparatus and ease operation. demonstrate ability to measure scattering fluid calibrated phantom model. Fluid was generated by syringe pump phantom's sampled volume contained millimeter size...
We demonstrate the ability of a novel device employing ultrasound modulation near infrared light (referred as "Ultrasound tagged light" or UTL) to perform non-invasive monitoring blood flow in microvascular level tissue. Monitoring microcirculatory is critical clinical situations affecting different organs, such brain limbs. . However, currently there are no devices that measure deep tissue continuously. Our prototype (Ornim Medical, Israel) was used monitor on anesthetized swine during...
Goal. The purpose of this computer modeling study is to validate the feasibility a home monitoring system for wrist bone mineral density (BMD) measurement which based on parametric electrical impedance tomography (pEIT) method. Methods. A solution forward problem developing potential around due current injection was developed using Matlab numerical simulation an adult human phantom. backward solved by building lookup table different densities represent disease stages. Results. real part...
We describe a stable and reproducible liquid tissue mimicking phantom optimized for applications involving both ultrasound light waves. The has optical acoustic properties similar to soft biological tissue. base material is Glycerol. TiO2 added the Glycerol as scattering particles. An absorbing dye obtain desired absorptions in Near IR range. phantom's absorption was measured by Spatially Resolved Spectroscopy (SRS). In addition, were calculated based on spatial decay of an acousto-optic...
Doxorubicin (DOX) is a widely used chemotherapeutic anticancer drug. Its intrinsic fluorescence properties enable investigation of tumor response, drug distribution and metabolism. First phantom studies in vitro showed optoacoustic property DOX. We therefore aimed to further investigate the DOX biological tissue order explore its potential as theranostic agent. analysed doxorubicin hydrochloride (Dox·HCl) liposomal encapsulated (Dox·Lipo), two common drugs for anti-cancer treatment clinical...
The International Photoacoustic Standardisation Consortium (IPASC) emerged from SPIE 2018, established to drive consensus on photoacoustic system testing. As imaging (PAI) matures research laboratories into clinical trials, it is essential establish best-practice guidelines for image acquisition, analysis and reporting, a standardised approach technical validation. primary goal of the IPASC create widely accepted phantoms testing preclinical PAI systems. To achieve this, has formed five...
An industrial prototype developed to control the microbiological safety of packaged UHT milk is described. The method used consists basically continuous through-transmission measurement travel time and signal amplitude an ultrasonic burst passing through commercial carton-like packages - Tetrabrik, Combibloc-, each placed in individual thermostatized cavities. changes velocity during incubation can be correlated with microorganisms growth. Previous studies made a variety types, containers...
Visualizing whole-body dynamics across entire living organisms is crucial for understanding complex biology, disease progression as well evaluating efficacy of new drugs and therapies. Existing small animal functional molecular imaging modalities either suffer from low spatial temporal resolution, limited penetration depth or poor contrast. In this work, we present flash scanning volumetric optoacoustic tomography (fSVOT) system that enables the acquisition speeds required visualizing fast...
In article number 2000484, Avihai Ron, Sandeep Kalva, and co-workers introduce a new biomedical imaging approach termed flash-scanning volumetric optoacoustic tomography (fSVOT). The method offers unprecedented abilities for preclinical whole-body anatomical, functional, molecular with superb contrast, resolution, speed, further enabling time-lapse fully multiplexed observations of contrast agent perfusion accumulation across multiple organs.
<p>All supplementary data</p>
<p>Figure S3 shows local oxygen saturation responses to a dynamic challenge in the different animals (n=6).</p>
<div>Abstract<p>Mapping tumor heterogeneity and hypoxia within a living intact organism is essential for understanding the processes involved in cancer progression assessing long-term responses to therapies. Efficient investigations into mechanisms have been hindered by lack of intravital imaging tools capable multiparametric probing entire solid tumors with high spatial temporal resolution. Here, we exploit volumetric multispectral optoacoustic tomography (vMSOT) accurate,...
<p>A time-lapse video of the Local sO2 responses in single voxels to an oxygen challenge</p>
<p>All supplementary data</p>
<p>Figure S1 shows averaged oxygen saturation profiles for three different tumors.</p>
<div>Abstract<p>Mapping tumor heterogeneity and hypoxia within a living intact organism is essential for understanding the processes involved in cancer progression assessing long-term responses to therapies. Efficient investigations into mechanisms have been hindered by lack of intravital imaging tools capable multiparametric probing entire solid tumors with high spatial temporal resolution. Here, we exploit volumetric multispectral optoacoustic tomography (vMSOT) accurate,...
<p>A time-lapse video of the Local sO2 responses in single voxels to an oxygen challenge</p>
<p>Figure S3 shows local oxygen saturation responses to a dynamic challenge in the different animals (n=6).</p>
<p>Figure S2 shows average oxygen saturation responses to a dynamic challenge for three different tumors.</p>
<p>Figure S1 shows averaged oxygen saturation profiles for three different tumors.</p>