Resistance to standard Helicobacter pylori (HP) treatment regimens has led unsatisfactory cure rates in HP-infected patients. This study was designed evaluate a novel four-drug regimen (three antibiotics and proton pump inhibitor (PPI)) for eradication of HP infection treatment-naive patients.Patients with diagnosis gastritis or peptic ulcer disease confirmed using endoscopy stool antigen testing were eligible inclusion this study. All patients underwent washout period 6 weeks from any prior...

Clostridium difficile infection (CDI) is a recent epidemic in the United States, particularly hospital setting. Oral metronidazole standard therapy for C. infection, but resistance to becoming clinical challenge.We evaluated efficacy of nonsystemic oral antibiotic rifaximin treatment metronidazole-resistant infection. Twenty-five patients with were enrolled study. All had mild-to-moderate (5-10 bowel movements day without sepsis) unresponsive (i.e. stools positive toxins A and B after 500 mg...

Objective: Antioxidants, including alpha lipoic acid (ALA) and vitamin E, are efficacious for the treatment of nonalcoholic fatty liver disease (NAFLD). The objective was to evaluate effects ALA E alone or combined as therapy patients with NAFLD steatohepatitis (NASH). Design: Placebo-controlled, open-label, prospective study in which NASH were randomized 300 mg (n = 40), 700 IU plus placebo 35) daily 6 months. Body mass index, homeostasis model assessment scores, fibrosis steatosis markers,...

Introduction: We aimed to assess the impact of socio-economic determinants health (SEDH) on survival disparities within and between ethnic groups young-onset (<50 years age) colorectal adenocarcinoma patients. Patients Methods: Surveillance, epidemiology, end results (SEER) registry was used identify patients aged 25–49 from 2012 2016. Survival analysis performed using Kaplan–Meir method. Cox proportional hazards model determine hazard effect SEDH. American community survey (ACS) data...

Background: Melatonin is a safe and effective treatment for patients with functional pain gastrointestinal disorders. Objective: To evaluate the efficacy safety of melatonin 3 months in heartburn. Methods: In randomized, placebo-controlled pilot study, heartburn were treated omeprazole 20 mg before breakfast randomized to receive either 6 (n = 20), nortripty line 25 or placebo 20) at bedtime months. Gastroesophageal Reflux Disease-Health-Related Quality Life (GERD-HRQOL) scores assessed...

Background and Objectives: Conflicting guidelines exist for initiating average-risk colorectal cancer screening at the age of 45 years. The United States Preventive Services Task Force (USPSTF) changed its in 2021 to recommend years due an increasing incidence young-onset cancer. However, American College Physicians (ACP) recently recommended not individuals between 49 old. We aim study national trends sporadic malignant polyps (SMP) patients from 20 Materials Methods: analyzed Surveillance,...

Adenoma detection rate (ADR) is challenging to measure, given its dependency on pathology reporting. Polyp (PDR) (percentage of screening colonoscopies detecting a polyp) proposed alternative overcome this issue. Overall PDR from all relatively novel concept, with no large-scale studies comparing overall screening-only PDR. The aim the study was compare screening, surveillance, and diagnostic indications evaluate any correlation between individual endoscopist by indication determine if can...

Introduction: Acute hepatitis C has been increasing in incidence recently the USA. Traditional management with peg IFN α2a and weight based RBV had equivocal success SVR rates as low 30% some studies considerable side events. Recently oral DAA's have achieved exceeding 95% many cohorts. This clinical pilot study evaluates efficacy of Sofosbuvir (SOF) Ledipasvir (LDV) or Simeprevir (SIM) acute Hepatitis Methods: 29 patients a diagnosis (negative past HCV antibody + new onset RNA) were...

Pneumobilia is defined as air within the biliary system. It usually caused by an abnormal connection between gastrointestinal tracts. Persistent asymptomatic pneumobilia a rare occurrence and generally considered benign finding on imaging. Herein, we present case of 87-year-old male with long-standing no identifiable cause who eventually developed Klebsiella cholangitis bacteremia. In our report, attempt to elucidate causes spontaneous discuss its significance in context increased...

Abstract Aim Gastrointestinal malignant melanoma is a rare mucosal (MM). Other MM include the respiratory and genitourinary tract. All melanomas have poor prognosis when compared to cutaneous melanomas. Ano-rectal are by far most common studied gastrointestinal MM. Large-scale clinical data lacking due rarity of disease. We aim analyze epidemiology survival (G.I.) over 45 years using national database. Methods The Surveillance, Epidemiology End Results (SEER) database was queried identify...

Introduction: Cirrhotics with CHC still remain a challenge. Co-infected cirrhotics (HIV+CHC) are at greater risk for rapid decompensation affecting quality of life (QOL) and have higher transplant burden. Interferon-based therapy entails longer duration an increased susceptibility infections marrow suppression warranting use growth factors even discontinuation therapy/treatment failure. Telaprevir, protease inhibitor (PI)-based therapy, has proved efficacious in co-infected patients. Newer...

Purpose: Non-alcoholic fatty liver disease (NAFLD) is a global epidemic. NAFLD progresses to non-alcoholic steatohepatitis (NASH), cirrhosis and cancer. Obesity insulin insensitivity the hallmark. Liver participates in glucose acid homeostasis. Nonexpelled free its toxic metabolites impact oxidative stress; radicals influx which initiate inflammatory cascade (NASH) activate fibrotic path causing cirrhosis. This clinical trial highlights effects of anti-oxidants NAFLD. Methods: One hundred...

Background: Traumatic intracranial hemorrhage (ICH) often triggers a systemic inflammatory response and arrhythmias. Atrial fibrillation (AF), the most frequent arrhythmia, is linked with inflammation, increasing cardiovascular mortality risk twofold. Methods: This study explores link between traumatic ICH AF through case of 70-year-old female brain injury (TBI) leading to AF. Comprehensive clinical assessments, imaging, laboratory tests were conducted understand relationship TBI, ICH,...

Purpose: Pegylated interferon alfa (PEG IFN-a) and Ribavirin(RBV) are the backbone of therapy Chronic Hepatitis C with Sustained Virological Response (SVR) ˜50%, globally in all genotypes. A recent study reveals correlation rapid viral response(RVR) to SVR. Alinia® (nitazoxanide) is an (IFN) inducer that may increase SVR when used combination IFN RBV. More response or Very Rapid Viral (VRVR) defined as undetectable load at 14 days after initiation predict even higher rates. We assessed...