A5068269640- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Plant Virus Research Studies
- DNA Repair Mechanisms
Universidade de São Paulo
2021-2024
Host manipulation is a common strategy for invading pathogens. Trypanosoma cruzi, the causative agent of Chagas Disease, lives intracellularly within host cells. During infection, parasite-associated modifications occur to cell metabolism and morphology. However, little known about effect T. cruzi infection on nucleus nuclear functionality. Here, we show that can modulate transcription splicing machinery in non-professional phagocytic cells during infection. We found regulates RNA polymerase...
Trypanosoma cruzi, the etiological agent of Chagas disease, invades many cell types affecting numerous host-signalling pathways. During T. cruzi infection, we demonstrated modulations in host RNA polymerase II activity with downregulation ribonucleoproteins transcription and splicing machinery. These alterations could be a result initial damage to DNA caused by presence parasite, however, mechanisms are not well understood. Herein, examined whether infection coincided enhanced cell. We...