A5002494950- Analytical Chemistry and Sensors
- Geology and Paleoclimatology Research
- 3D Printing in Biomedical Research
- Carbon and Quantum Dots Applications
- Electrochemical sensors and biosensors
- Nanoplatforms for cancer theranostics
- Molecular Sensors and Ion Detection
- Evolution and Paleontology Studies
- Plant Diversity and Evolution
- Advanced Nanomaterials in Catalysis
- Bone Tissue Engineering Materials
- Endodontics and Root Canal Treatments
- Nanocluster Synthesis and Applications
- Marine and environmental studies
- Microfluidic and Capillary Electrophoresis Applications
- Plant and Fungal Species Descriptions
- Innovative Microfluidic and Catalytic Techniques Innovation
- Paleontology and Stratigraphy of Fossils
- Electrospun Nanofibers in Biomedical Applications
- Dental materials and restorations
- Dental Radiography and Imaging
- Nanoparticle-Based Drug Delivery
- Marine and coastal plant biology
- Connective tissue disorders research
- Silk-based biomaterials and applications
Jain University
2023-2024
Istituto di Nanotecnologia
2020-2022
National Research Council
2020-2022
Institute of Nanotechnology
2020
National Academies of Sciences, Engineering, and Medicine
2020
Istituto Nanoscienze
2020
King George's Medical University
2014-2018
Indian Institute of Technology Delhi
2014-2018
National Chemical Laboratory
2014
Sanjay Gandhi Post Graduate Institute of Medical Sciences
2014
Despite the promising photophysical properties of fluorescent graphene quantum dots (GQDs), their cellular toxicity needs to be addressed before full potential could completely realized in biomedicine. A simple method for mitigating GQDs by embedding them PEG matrix is reported here. The enhanced biocompatibility polymer modified, P-GQDs, attributed reduced reactive oxygen species generation, as measured an intracellular ROS assay. We also demonstrate loading and efficient delivery...
The design of powerful in vitro cell culture platforms to support precision medicine can contribute predict therapeutic success cancer patients. Electrospun nanofibers applied mimic extracellular matrix and improve behavior. Here, we describe biocompatible blended polyvinyl-alcohol (PVA)/gum arabic (GA) (ECM)-like for cultures capable delivering nanocomposite desired biomedical application. Therefore, PVA/GA ECM-like electrospun were developed characterized. Heat treatment was used crosslink...
We report here a 3D cell culture microgel-based system containing carbon dots capable of sensing the pH changes in cellular microenvironment. have utilized simple droplet-based microfluidics methodology for encapsulating cells and fluorescent sensitive polyethylene glycol microgels. Since assembly is developed from components that can be modified easily to yield microgels different size, composition, architecture, it develop complex scaffolds desired composition along with spatial control on...
We report the development of a platform for sensing bacterial growth by observing pH change via in fluorescence. While allows rapid detection bacteria it is sensitive enough to detect even ∼104 CFU bacteria. The can differentiate between resistant and non-resistant strains E. coli ∼4 6 hours, which better than currently used clinical methods.
The detection of extracellular pH at single cell resolution is challenging and requires advanced sensibility. Sensing high spatial temporal might provide crucial information in understanding the role its fluctuations a wide range physio-pathological cellular processes, including cancer. Here, method to embed silica-based fluorescent sensors into alginate-based three-dimensional (3D) microgels tumour models, coupled with computational for fine data analysis, presented. By means confocal laser...
Abstract We report here carbon dots (CDs) that can be utilized for intracellular pH sensing via fluorescence emission monitoring. The are synthesized using a simple procedure from an economical source Agaricus bisporus . Along with the excitation dependent emission, typical to dots, these CDs were found have distinct maxima peaks at 450 nm and 550 when excited by 365 500 respectively. Interestingly, while was unaffected changes in solution, intensity increased decrease pH, making potential...
Abstract Despite numerous advances in the field of tissue engineering and regenerative medicine, monitoring formation regeneration its metabolic variations during culture is still a challenge mostly limited to bulk volumetric assays. Here, simple method adding capsules‐based optical sensors cell‐seeded 3D scaffolds presented potential these monitor pH changes space time cell growth demonstrated. It shown that decreased over scaffolds, with more prominent decrease at edges scaffolds....
Pyranine (HPTS) is a remarkably interesting pH-sensitive dye that has been used for plenty of applications. Its high quantum yield and extremely sensitive ratiometric fluorescence against pH change makes it very favorable pH-sensing applications the development nano-/microsensors. However, its strong negative charge lack easily modifiable functional groups difficult to use with charged substrates such as silica. This study reports methodology noncovalent HPTS immobilization on silica...
Fluorescence imaging allows for non-invasively visualizing and measuring key physiological parameters like pH dissolved oxygen. In our work, we created two ratiometric fluorescent microsensors designed accurately tracking oxygen levels in 3D cell cultures. We developed a simple cost-effective method to produce hybrid core-shell silica microparticles that are biocompatible versatile. These sensors incorporate oxygen-sensitive probes (Ru(dpp) or PtOEP) reference dyes (RBITC A647 NHS-Ester)....
pH balance and regulation within organelles are fundamental to cell homeostasis proliferation. The ability track in cells becomes significantly important understand these processes detail. Fluorescent sensors based on micro- nanoparticles have been applied measure intracellular pH; however, an accurate methodology precisely monitor acidification kinetics of living has not established, limiting the scope this class sensors. Here, silica-based fluorescent microparticles were utilized probe...
The homeostatic control of their environment is an essential task living cells. It has been hypothesized that, when microenvironmental pH inhomogeneities are induced by high cellular metabolic activity, diffusing protons act as signaling molecules, driving the establishment exchange networks sustained cell-to-cell shuttling overflow products such lactate. Despite fundamental role, extent and dynamics largely unknown due to lack methods in single-cell flux analysis. In this study, we provide...
Associations of miospores and marine acritarchs are described from the intercalations in Lower Gondwanas near Manendragarh Umaria. The mioflora is typically Talchir its dominating content monosaccate forms. Associated very rare. Umaria assemblage poor but arc abundant amongst which Foveofusa gen. nov. distinguished. palynological, biostratigraphical environmental aspects palynological associations briefly discussed.
Background: Oligodendrogliomas are infiltrative astrocytic tumors. They constitute about 1-5% of intracranial These have been graded into benign and malignant grades. The single nucleotide polymorphisms (SNPs) in the promoter regions MMP genes may influence tumor development progression. This study was done to explore correlations SNPs MMP-1, MMP-2 MMP-7 susceptibility progression oligodendrogliomas. Objectives: We aimed investigate association MMP1 (−1607A > G), (−1306 C/T) MMP-7(−181A...
Miospore assemblages are, for the first time, recorded from Talchir Boulder Bed and overlying Needle Shales in South Rewa Basin: The assemblage contains 13 genera 20 species, while shales have 17 24 species. Both assemblages, having several common taxa, are predominated by monosaccate pollen as is generally characteristic of other known miofloras. In details composition, however, appears to be distinct that similar sediments Jayanti Coalfield. present findings lend further support existence...
Objective: To comparatively evaluate the cytotoxicity of EndoREZ (urethane dimethacrylate based), RoekoSEAL (silicone based) and Kalsogen Plus (ZOE sealers on HEK-293 (human embryonic kidney epithelial cells) Vero (African green monkey cell lines in vitro.Materials methods: Sealers EndoREZ, were mixed according to manufacturer's instructions.Extract these then treated with cultured (HEK-293 Vero), evaluated using MTT assay.Cytotoxicity between fresh set specimens at 0h, 24h, 48h, 72h 1wk...
Palynological assemblage from DSDP Site 218 in the Bengal Fan comprises spores, pollen, fungal fruiting bodies and dinoflagellate cysts. The palynofloral composition has minor variation core no. 27 to 12. microthyriaceous remains show comparatively higher frequency than other entities. gymnosperms are represented mostly by pollen grains of Podocarpaceae Araucariaceae. Angiosperm sparsely observed assemblage. pteridophytic spores occur bottom middle cores (core nos. 27-26 23-20). Recycled...
Arberia surangei sp. nov. has been described from the coal-bearing (Karharbari?) formation of Birsinghpur Pali, Madhya Pradesh. The species Arberia, so far known India, are also reviewed.