A5009145170- Cell death mechanisms and regulation
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- interferon and immune responses
- PARP inhibition in cancer therapy
- Ubiquitin and proteasome pathways
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Trypanosoma species research and implications
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer therapeutics and mechanisms
- Biochemical and Molecular Research
- Cancer-related Molecular Pathways
- Cancer-related gene regulation
- Aquaculture disease management and microbiota
- CRISPR and Genetic Engineering
- Nitric Oxide and Endothelin Effects
- Signaling Pathways in Disease
- Cytomegalovirus and herpesvirus research
- Pancreatic function and diabetes
- MicroRNA in disease regulation
Keele University
2009-2022
British Geological Survey
2016
Natural Resources Canada
2009-2012
Sydney Children’s Hospitals Network
2004
St George's Hospital
1981-2000
St George's, University of London
1981-2000
University of Birmingham
1983-1993
University of Wales
1990
The Edgbaston Hospital
1986
Medical Research Council
1986
The control of growth lymphocyte populations is crucial to the physiological regulation immune system, and prevention both leukaemic autoimmune disease. This mediated through modulation cell cycle death. During log-phase rate proliferation high there a low As population density increases, extended apoptosis becomes more frequent as enters arrest. Here, we show that growth-arrest-specific transcript 5 (GAS5) plays an essential role in normal arrest T-cell lines non-transformed lymphocytes....
Herein we have investigated the ability of antigen to induce thymocyte death by apoptosis on basis that this may be mechanism for deletion autoreactive cells during T cell development. We show bacterial "superantigen" staphylococcal enterotoxin B cause specific depletion Vβ8+ when added thymus organ cultures is accompanied DNA degradation into oligonucleosomal fragments, indicating involves apoptosis. Our results provide first direct evidence antigen-induced can triggered in developing cells.
Programmed cell death through apoptosis plays an essential role in the hormone-regulated physiological turnover of mammary tissue. Failure this active gene-dependent process is central both to development breast cancer and appearance therapy-resistant cells that produce clinical relapse. Functional expression cloning two independent laboratories has identified Finkel–Biskis–Reilly murine sarcoma virus-associated ubiquitously expressed gene (Fau) as a novel regulator candidate tumour...
BACKGROUND New therapies are required for castrate‐resistant prostate cancer (CRPC), and growth‐arrest specific 5 (GAS5) lncRNA, which riborepresses androgen receptor action, may offer novel opportunities in this regard. This lncRNA promotes the apoptosis of cells its levels decline as acquire castrate‐resistance, so that enhancing GAS5 expression improve effectiveness chemotherapies. Since is a member 5' terminal oligopyrimidine gene family, we have examined mTOR inhibition strategy to...
// Mark R. Pickard 1 , Gwyn T. Williams Apoptosis Research Group, School of Life Sciences, Keele University, ST5 5BG, United Kingdom Correspondence to: Pickard, e-mail: m.r.pickard@keele.ac.uk Keywords: GAS5, lncRNA, apoptosis, breast cancer, oligonucleotide therapy Received: September 30, 2015 Accepted: January 23, 2016 Published: February 03, ABSTRACT Growth arrest-specific 5 (GAS5) lncRNA promotes and its expression is down-regulated in cancer. GAS5 a decoy glucocorticoid/related...
IDDM results from a progressive loss of pancreatic beta-cells that, in humans, may be triggered by combination genetic and environmental factors. Recently, attention has been focused on the hypothesis that is initiated inappropriate induction apoptosis. We now demonstrate human islets Langerhans undergo apoptosis upon exposure to interleukin-1beta. The cytokine also sharply increases number cells enter treatment with stimulatory anti-Fas antibody. Western blotting immunocytochemistry clearly...
The central importance of the serine/threonine protein kinase mTOR (mammalian Target Rapamycin) in control cell growth and proliferation is well established. However, our knowledge both upstream pathways controlling activity downstream events mediating these effects still seriously incomplete. We report a previously unsuspected role for nonprotein-coding RNA GAS5 inhibition T-cell produced by antagonists such as rapamycin. transcripts are up-regulated during arrest after rapamycin treatment,...