A5076030951- Pancreatic function and diabetes
- Aldose Reductase and Taurine
- Pituitary Gland Disorders and Treatments
- Ovarian function and disorders
- Growth Hormone and Insulin-like Growth Factors
- Diet, Metabolism, and Disease
- Cardiovascular Function and Risk Factors
- Diabetes Management and Research
- Diabetes Treatment and Management
- Menopause: Health Impacts and Treatments
- Neonatal Health and Biochemistry
- Cardiac Ischemia and Reperfusion
- Estrogen and related hormone effects
- Retinal Imaging and Analysis
- Metabolism and Genetic Disorders
- Diabetes and associated disorders
- Alcohol Consumption and Health Effects
- Reproductive Biology and Fertility
- Diabetes Management and Education
- Diet and metabolism studies
- Gynecological conditions and treatments
- Neurological and metabolic disorders
- Hemoglobin structure and function
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Mitochondrial Function and Pathology
Case Western Reserve University
2023
Yale University
2023
Abbott Fund
2023
North American Menopause Society
2023
University of Colorado Denver
2020-2023
National Institute on Aging
2003-2023
Massachusetts General Hospital
2020-2023
National Institute of Nursing Research
2023
National Institutes of Health
2023
University of Massachusetts Chan Medical School
2023
Previous reports have suggested that estrogen replacement therapy (ERT) in women may exert a protective effect on their risk of developing Alzheimer9s disease (AD). We investigated this relationship the Baltimore Longitudinal Study Aging (BLSA), prospective multidisciplinary study normal aging conducted by National Institute Aging. The sample consisted 472 post- or perimenopausal followed for up to 16 years BLSA. documented ERT prospectively at each BLSA visit, and we categorized who had...
<b><i>Background:</i></b> Recent studies have suggested that AD may reflect a chronic process begins many years before the clinical expression of dementia. The current study examines premorbid Benton Visual Retention Test (BVRT) and Wechsler Adult Intelligence Scale–vocabulary (WAIS-voc) test scores in order to determine whether long-term deficits these tests can predict development decades later Baltimore Longitudinal Study Aging (BLSA). <b><i>Method:</i></b> Participants are volunteers...
Human erythrocytes incubated in medium containing 50 mM glucose have increased intracellular sorbitol and fructose concentrations as compared with samples 5 glucose. Increased concentration did not significantly alter total consumption or lactate production. However, the lactate:pyruvate ratio rose, of diphosphate, triose phosphates increased, 2,3-diphosphoglycerate fell. [(14)C]O(2) production from glucose-1-(14)C also concentration. These changes are believed to reflect redox states...
Abstract Background A test that helps predict the time to final menstrual period (FMP) has been sought for many years. Objective To assess ability of antimullerian hormone (AMH) measurements predictions FMP. Design Prospective longitudinal cohort study. Setting The Study Women’s Health Across Nation. Participants and Measurements AMH FSH were measured in 1537 pre- or early perimenopausal women, mean age 47.5 ± 2.6 years at baseline, then serially until 12 months amenorrhea occurred. was...
Data in the literature suggest that circulating levels of lipoprotein(a) [Lp(a)] and insulinlike growth factor I (IGF-I) respond similarly to therapy with hormone, estrogen, or tamoxifen. To more clearly document these relations, we designed a randomized, double-blind, placebo-controlled study effects tamoxifen continuous estrogen on Lp(a), IGF-I, IGF binding protein 3 (IGFBP-3) healthy postmenopausal women. Both decreased serum IGF-I 30% below baseline during months treatment, while IGFBP-3...
A seasonal component to bone loss has been reported in some postmenopausal women. We hypothesized that elderly women northern New England would be at high risk for during winter because of their age, diet and lack sunlight. Eighteen but healthy (mean age 77 years) started a 2-year observational study remote area northwestern Maine (Greenville: 45.5°N latitude). Fifteen completed the study. Bone mineral density spine (L-BMD) hip (F-BMD) biochemical markers turnover were measured biannually....
Aldose reductase is present in human and rabbit aortas provides a mechanism whereby hyper-glycemia can alter the metabolism of arterial wall. Aortic sorbitol concentration regulated by ambient glucose increased epinephrine, isoproterenol, dibutyryl-3',5'-adenosine monophosphate, ouabain, angiotensin II.
An in vitro preparation of rabbit aortic "intima-media" previously shown to exhibit stable rates respiration and glucose metabolism the high rate aerobic glycolysis considered characteristic this tissue was subjected electron microscopic examination. In samples examined immediately after aortae were dissected free adipose adventitia, under conditions similar those now common use, marked widespread alterations endothelial cell structure present, including loss integrity. The vascular smooth...
The effects of elevated glucose concentrations on the metabolism aortic wall were examined in a preparation tubular segments rabbit descending thoracic aorta comprised intima and media only. Increased medium (20-50 mm) resulted increased sorbitol fructose an rate release into medium. This flux through polyol pathway can be explained as consequence both free intracellular concentration kinetic characteristics alditol: NADP oxidoreductase l-iditol: NAD isolated partially purified from aorta....
The Diabetes Control and Complications Trial (DCCT) demonstrated the powerlul impact of glycemic control on progression diabetic retinopathy. A large number individuals (2,771) underwent stereoscopic color photography fluorescein angiography as part screening for participation in DCCT. subgroup those screened participated DCCT evaluation their retinal vasculature semiannually 4-9 years. These data were evaluated to determine how 2000 American Association position statement would apply...
Abstract Background Innovative approaches to the widespread delivery of evidence‐based dementia care are needed. The aims this study were determine whether a telephone screening method could efficiently identify individuals in community need for and develop multidimensional needs assessment tool identifying type frequency unmet related memory disorders home setting. Methods This was cross‐sectional evaluation 292 community‐residing aged 70 older Maryland. Participants given brief cognitive...
Glucose effects on islet phospholipids were examined during direct incubation or after 3 days of 32P prelabeling in primary culture. In both cases, glucose increased the content phosphatidic acid (PA), phosphatidylinositol (PI), and polyphosphoinositides (PPI). Glucose-induced increases PA, PI, PPI culture-prelabeling experiments evident within 1 min, dose related, reflective phospholipid mass, which was confirmed incubations by measurement PI phosphorus. Thus, addition to increasing PI-PPI...
Paired samples of an intact rabbit aortic intima-media preparation were incubated for short periods under aerobic or anoxic conditions in Krebsbicarbonate buffer containing 6% albumin and 5 mM glucose. During incubation as long 1 h the retained electron microscopic (EM) appearance similar to that tissue fixed situ, scanning EM confirmed presence uninterrupted endothelial surface. After 2.5 min anoxia there was widespread swelling, but alterations these cells not striking did progress during...
Background. The incidence of medical failure for prolactin (PRL)-secreting pituitary tumours is not well known. Object. purpose this study to report clinical, radiographic and laboratory findings PRL-secreting that predict failed management. Methods. An analysis 92 consecutive patients was performed met the inclusion criteria. Decision surgery made based on dopamine agonists either control clinical symptoms normalise hormonal level or diminish mass effect follow-up evaluation. Results. Of...
The efficacy of soluble immune complexes (IC) different sizes prepared in vitro or present RA sera and synovial fluids to induce the release β-glucuronidase (BG) neutral protease (NP) from PMN has been examined. Immune human HGG-rabbit anti-human HGG 5, 10 20 times excess antigen equivalence were fractionated into three pools, PI (22S-13S), PII (13S-7S) PHI (7S) using Sephadex G-200 column chromatography. NP BG-releasing activity was mostly associated with PII. Similar fractions obtained...