A5103058902- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Advancements in Transdermal Drug Delivery
- Crystallization and Solubility Studies
- Polysaccharides Composition and Applications
- Crystallography and molecular interactions
- Synthesis and biological activity
- Polysaccharides and Plant Cell Walls
- Nanocomposite Films for Food Packaging
- Hydrogels: synthesis, properties, applications
- Click Chemistry and Applications
- Pineapple and bromelain studies
- Curcumin's Biomedical Applications
- Nonlinear Optical Materials Research
- Complementary and Alternative Medicine Studies
- Advanced Cellulose Research Studies
- Proteoglycans and glycosaminoglycans research
- Computational Drug Discovery Methods
- Analytical Methods in Pharmaceuticals
- Carbohydrate Chemistry and Synthesis
- Synthesis and Characterization of Heterocyclic Compounds
- Health Systems, Economic Evaluations, Quality of Life
- Biochemical and Structural Characterization
- Research on Leishmaniasis Studies
- Ocular Surface and Contact Lens
Guru Jambheshwar University of Science and Technology
2015-2025
Central Council for Research in Homoeopathy
2015-2024
To overcome problems associated with topical delivery of tacrolimus (TCS), a thermoresponsive in situ gel system containing pluronic F127 (PL), and chitosan (CS) was developed, to enhance the precorneal retention, sustain release drug. The PL-CS optimized using 2-factor-3-level central composite experimental design by selecting concentration PL CS as independent variables while gelation time, temperature, spreadability dependent variables. formulation developed 22.5 g 0.3 CS, gels at 33.6...
Background: Azole and sulfonamide molecular frameworks are endowed with potent antimicrobial activity. Materials & methods: A series of azole–sulfonamide conjugates were synthesized using click reaction N-propargylated imidazole azide its efficacy was evaluated. Results: The compounds 7c, 7i 7r displayed promising antibacterial activities, better than the standards norfloxacin. All molecules exhibited antifungal activity, more fluconazole. Docking studies active signified importance...
Prokinetic agents are drugs used to enhance gastrointestinal motility and treat disorders such as Gastroesophageal Reflux Disease (GERD) gastroparesis. pH-dependent release systems offer targeted drug delivery, allowing prokinetic be released specifically in desired regions of the tract. This optimizes efficacy minimizes systemic side effects. Gastroretentive formulations enable sustained release, which is particularly beneficial conditions requiring prolonged gastric residence time,...
Thiol functionalization of psyllium was carried out to enhance its mucoadhesive potential. Thiolation achieved by esterification with thioglycolic acid. observed change the surface morphology from fibrous granular and result in a slight increase crystallinity swelling. Thiolated found contain 3.282 m moles thiol groups/g polymer. Mucoadhesive applications thiolated psylium were explored formulating gels using metronidazole as model drug. On comparative evaluation showed 3‐fold higher...
The aim of the present study was to improve release rate curcumin by microsponges prepared through quasi-emulsion solvent diffusion technique using ethylcellulose and PVA as carriers. were characterized FTIR, DSC, XRD SEM studies followed determination total drug content entrapment efficiency. further filled in hard gelatin capsule shell then loaded carbopol gel evaluate its potential oral topical delivery. Further, it observed from on that shells (batch MS4) showed 93.2% whereas pure only...
The purpose of the present study was to prepare itraconazole-loaded chitosan nanosuspension and evaluate it for ocular delivery. Itraconazole-loaded prepared by controlled co-precipitation itraconazole from aqueous acetate solution using a combination pH change non-solvent addition. co-precipitated suspension evaluated particle size, zeta-potential, entrapment efficiency solubility study. It observed that chitosan–lysine system in presence Poloxamer-188 as stabiliser provided smallest size...
In the present study piroxicam loaded starch nanoparticles were prepared to enhance solubility of by nanoprecipitation technique. The preparation was carried out as per central composite experimental design protocol, having concentration and drug independent variables particle size polydispersity index (PdI) dependent variables. PdI found be between 282-870 nm 0.339-0.772, respectively. After characterization FT-IR, TGA, XRD SEM studies, optimized batch evaluated for in-vitro release study,...
Background: Considering emerging drug resistance in microbes, this work is focused on the synthesis of azole hybrids as novel antimicrobials. Materials & methods: The triazole derivatives were prepared using azide alkyne cycloaddition reaction. antimicrobial potential these compounds was evaluated by serial dilution method. Results: A series containing benzimidazole-1,2,3-triazole skeleton designed and synthesized via click Compound 4s showed notable activity against Staphylococcus aureus...
The co-crystallization of pharmaceutical drugs is gaining consideration because it an environmentally friendly and potentially effective technique to improve the solubility bioavailability poorly soluble drugs.