A5050363056- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Drug Solubulity and Delivery Systems
- Nanoparticle-Based Drug Delivery
- Essential Oils and Antimicrobial Activity
- Ocular Surface and Contact Lens
- RNA Interference and Gene Delivery
- Analytical Methods in Pharmaceuticals
- Curcumin's Biomedical Applications
- Phytochemicals and Antioxidant Activities
- Nanoparticles: synthesis and applications
- Nanoplatforms for cancer theranostics
- Ocular Infections and Treatments
- Systemic Lupus Erythematosus Research
- Dermatology and Skin Diseases
- Advanced Nanomaterials in Catalysis
- Food Chemistry and Fat Analysis
- Drug Transport and Resistance Mechanisms
- Proteins in Food Systems
- Enzyme function and inhibition
- 3D Printing in Biomedical Research
- Lipid Membrane Structure and Behavior
- Bee Products Chemical Analysis
- Additive Manufacturing and 3D Printing Technologies
- Electrochemical sensors and biosensors
Taif University
2018-2025
Jamia Hamdard
2010-2018
Galgotias University
2016-2017
Hamdard University
2011-2015
Cancer is among the most dreadful fatal diseases globally, and efficacy of recent chemotherapeutic approaches limited due to many related drawbacks. The major limitation associated with cancer chemotherapy poor aqueous solubility anticancer drugs, development multidrug resistance, low bioavailability, small plasma half-life, serious side effects healthy tissues unspecific distribution drugs. Advancement in nanoscience provides means specific selective targeting cells. Chitosan, one naturally...
The goal of current research was to develop a new form effective drug, curcumin-loaded solid lipid nanoparticles (Cur-SLNs) and test its efficacy in the treatment lung cancer. Different batches SLNs were prepared by emulsification–ultrasonication method. For optimization formulation, each batch evaluated for particle size, polydispersity index (PI), zeta potential (ZP), entrapment efficiency (EE) drug loading (DL). formulation components process parameters largely affected quality SLNs....
To overcome problems associated with topical delivery of tacrolimus (TCS), a thermoresponsive in situ gel system containing pluronic F127 (PL), and chitosan (CS) was developed, to enhance the precorneal retention, sustain release drug. The PL-CS optimized using 2-factor-3-level central composite experimental design by selecting concentration PL CS as independent variables while gelation time, temperature, spreadability dependent variables. formulation developed 22.5 g 0.3 CS, gels at 33.6...
A comparative study of physical parameters selected ketorolac tromethamine tablets available in the pharma market BangladeshNishat Nasrin, Muhammad Asaduzzaman, Rumana Mowla, Farhana Rizwan, Ashiqul Alam
Breast cancer is the most common in females and ranked second after skin cancer. The use of natural compounds a good alternative for treatment breast with less toxicity than synthetic drugs. aim present study to develop characterize hybrid Apigenin (AN) Nanoparticles (NPs) oral delivery (AN-NPs). AN-NPs were prepared by self-assembly method using lecithin, chitosan TPGS. Further, NPs optimized Box-Behnken design (3-factor, 3-level). evaluated particle size (PS), entrapment efficiency (EE),...
A wound refers to a cut or blow that may result in primary secondary infection even death, if untreated. In the current study, we have explored wound-healing properties of lidocaine nanogel, owing its antioxidant and neutrophilic modulatory potential. Initially, pre-formulation study was performed then using central composite design (CCD) fabrication characterization lidocaine-loaded nanoemulsion carried out. After preparation nanogel nanoemulsion, it evaluated on various parameters, such as...
Cerium oxide nanoparticles (CNPs), owing to their antioxidant property, have recently emerged as therapeutic candidate for Alzheimer's disease (AD). However, intravenous CNPs are limited due poor physicochemical properties, rapid blood clearance and blood-brain penetration. Thus, we developed intranasal evaluated its potential in experimental AD. were synthesized using homogenous precipitation method optimized through Box-Behnken Design. The formation of was confirmed by UV spectroscopy...
Encapsulation of Ganciclovir in lipophilic vesicular structure may be expected to enhance the oral absorption and prolong existence drug systemic circulation. So purpose present study was improve bioavailability by preparing nanosized niosomal dispersion. Niosomes were prepared from Span40, Span60, Cholesterol molar ratio 1:1, 2:1, 3:1, 3:2 using reverse evaporation method. The developed dispersions characterized for entrapment efficiency, size, shape, vitro release, release kinetic study,...
Aim: The current study aimed to explore the feasibility of nanoemulgel for topical delivery aceclofenac. Materials & methods: Solubility drugs in formulation systems was determined and aceclofenac nanoemulsion (NE) prepared by high-pressure homogenization technique. Carbopol 940 added as a gelling agent. Results conclusion: composition optimized NE consist labrafil along with triacetin oil, tween 80 cremophor EL combination surfactant transcutol HP PEG 400 ethanol cosurfactant. droplet size...
Santolina chamaecyparissus is an important medicinal plant growing in the Mediterranean region and has been reported as a potent anti-inflammatory, antibacterial, antioxidant, antifungal agent. The purpose of current research to identify chemical constituents ethyl acetate extract (EAE) from leaves S. chamaecyparissus, evaluate antidiabetic, anticancer activity. Chemical EAE were identified by GC-MS, antidiabetic activity was evaluated α-glucosidase inhibition assay. assessed Epidermal...
Introduction: Cerium oxide nanoparticles (CONPs) have been investigated for their therapeutic potential in Parkinson's disease (PD) due to potent and regenerative antioxidant activity. In the present study, CONPs were used ameliorate oxidative stress caused by free radicals haloperidol-induced PD rats following intranasal administration. Method: The of was evaluated vitro using ferric reducing power (FRAP) assay. penetration local toxicity ex-vivo goat nasal mucosa. acute also studied rat....
A lipid-based nanocarrier system is a novel technique for the delivery of poorly soluble drugs through topical delivery. This study developed dual-drug (luliconazole: LZ, and niacinamide: NM) loaded lipid (LN)-laden gel treatment vaginal candidiasis. The LNs were prepared using cholesterol soya-α-lecithin thin-film hydration technique. average vesicle size, polydispersity index, zeta potential optimized LZNMLNs 126.40 ± 1.30 nm, 0.276, -34.6 0.8 mV, respectively, formulation showed sustained...
Among primary brain tumors, glioma has one of the highest fatality rates. Routine chemotherapy often faces off-target drug loss and sub-optimal availability at tissue. The present study aims development transferrin-conjugated gemcitabine loaded poly (lactic co glycolic acid) nanoparticles (Tf-GB-PLGA-NPs) targeted strategy for cancer cell. GB-PLGA-NPs were prepared using solvent evaporation nanoprecipitation method then conjugated with Tf. formulation was characterized physicochemical...