Retinyl palmitate is a vitamin A ester belonging to the family of endogenous natural retinoid and used treat various skin disorders like acne, aging, wrinkles, dark spots, as well protect against psoriasis. Despite known therapeutic benefits retinyl palmitate, conventional topical delivery commonly associated with adverse reactions such irritation, redness, excessive peeling, dryness. Therefore, current study aims encapsulate in nanoemulsion then incorporate it into hydrogel system improve...

The concept of tailored medicine for individual patients have been around a while but recently earned much attention. Great interest is given to 3D printing technology due its immense application potential in the pharmaceutical industry and other health care sectors. involves Layer-by-layer fabrication 3Dgra objects from digital designs. This review gives detailed yet much-focused discussion about technology, outline printing-based drug delivery product development process. Based on method...

The current investigation aimed to improve the topical efficacy of imiquimod in combination with curcumin using nanoemulsion-based delivery system through a combinatorial approach. Co-delivery acts as an adjuvant therapeutic and minimize adverse skin reactions that are frequently associated therapy for treatment cutaneous infections basal cell carcinomas. low-energy emulsification method was used nano-encapsulation nanodroplet oil phase, which stabilized Tween 20 aqueous dispersion system....

Thymoquinone is a natural bioactive with significant therapeutic activity against multiple ailments including wound healing. The poor aqueous solubility and low skin permeability limit its efficacy. present investigation aimed to improve the biopharmaceutical attributes of thymoquinone enhance topical efficacy in A nanoemulsion-based hydrogel system was designed characterized as nanotechnology-mediated drug delivery approach thymoquinone, utilizing high-energy emulsification technique. black...

Introduction Triple-negative breast cancer (TNBC) presents unique challenges indiagnosis and treatment.Resveratrolexhibits potential as a therapeutic intervention for TNBC byregulating various pathways such the PI3K/AKT, RAS/RAF/ERK, PKCδ,and AMPK, leading to apoptosis through ROS-mediated CHOP activationand expression of DR4 DR5. However, clinical efficacy resveratrol is limited due itspoor biopharmaceutical characteristics low bioavailability at thetumor site. Nanotechnology offers...

Hydrogels being a drug delivery system has great significance particularly for topical application in cutaneous open wound. Its specific physicochemical properties such as non-adhesiveness, moisture retention, exudate absorption, and gas permeability make them ideal vehicle wound healing application. Further, curcumin (a natural bioactive) was selected therapeutic agent to incorporate into the hydrogel design develop nanogel pharmaceutical products healing. Although, possesses remarkable...

The 3D printing techniques have been explored extensively in recent years for pharmaceutical manufacturing and drug delivery applications. current investigation aims to explore the design development of a nanomedicine-based oral solid dosage form poorly water-soluble drug. A self-nanoemulsifying tablet formulation dapagliflozin propanediol monohydrate was developed utilizing semisolid pressure-assisted microsyringe (PAM) extrusion-based technique. system consists two major components (liquid...

3D printing of pharmaceutical formulations requires juggling between the material properties and process to achieve geometry printed products with desired dose release. The purpose current investigation is identify suitability for semisolid extrusion-based advanced drug delivery system. In this study, technique was optimized print a controlled release shell as vehicle/carrier oral consistency printable paste by screening different solvents polymer interest (cellulose acetate optimum)...

Interest in nanoemulsion technology has increased steadily recent years for its widespread applications the delivery of pharmaceuticals, nutraceuticals, and cosmeceuticals. Rational selection composition preparation method is crucial developing a stable system with desired physicochemical characteristics. In present study, we investigate influence intricate factors including conditions that affect characteristic parameters stability formation prepared by spontaneous emulsification method....

A primary energy consumption and CO2 emission source stems from buildings infrastructures due to rapid urbanisation social development. An accurate method forecast in a building is thus critically needed enable successful management of adaptive ease the level emission. However, forecasting for buildings, especially residential has several challenges, such as significant variations usage patterns unpredicted demands residences some intricate factors, which can randomly affect patterns....

The use of 3D printing techniques to control drug release has flourished in the past decade, although there is no generic solution that can be applied full range drugs or solid dosage forms. present study provides a new concept, using technique print coating system form shells with various designs control/modify immediate-release tablets. A cellulose acetate an encapsulating shell was printed through extrusion-based technology, where propranolol HCl tablet placed inside achieve sustained...

Curcumin (CUR) has impressive pharmacologic properties, including cardioprotective, neuroprotective, antimicrobial, and anticancer activity. However, the pharmaceutical application of CUR is limited due to its poor aqueous solubility low bioavailability. The development novel formulations attracted considerable attention idea applying nanobiotechnology improve therapeutic efficacy these challenging compounds. In this study, CUR-loaded lecithin−chitosan nanoparticles (CUR/LCSNPs) were...

Aim: The current study aimed to explore the feasibility of nanoemulgel for topical delivery aceclofenac. Materials & methods: Solubility drugs in formulation systems was determined and aceclofenac nanoemulsion (NE) prepared by high-pressure homogenization technique. Carbopol 940 added as a gelling agent. Results conclusion: composition optimized NE consist labrafil along with triacetin oil, tween 80 cremophor EL combination surfactant transcutol HP PEG 400 ethanol cosurfactant. droplet size...

Objective: This research aimed to assess the level of satisfaction among mental patients at Armed Forces Hospital Southern Region (AFHSR) in Asser, Saudi Arabia, and determine a link between demographic factors. Methods: A descriptive cross-sectional was conducted from August November 2024. The comprised 400 AFHSR. Face-to-face interviews were collect data, which included an Arabic version Charleston Psychiatric Outpatient Satisfaction Scale (CPOSS) other sociodemographic Results: average...

Introduction and aim: Cardiovascular diseases are a major cause of morbidity mortality on the rise in developing countries, including Saudi Arabia. This analytical cross-sectional study aimed to identify prevalence such modifiable lifestyle risk factors (LRFs) for cardiovascular (CVDs) among adults Taif city, Kingdom Arabia (KSA), where urbanization is taking place at very fast pace. Methods: In this case, 300 people responded survey that adopted stratified random sampling method recruit...

The accelerated transformation in the healthcare system supported by Saudi Vision 2030 makes present best time to start real application of pharmacogenomics Arabia. current study aimed assess knowledge, perception and status among pharmacists hospital settings Arabia.This cross-sectional observational survey was conducted 206 qualified working hospitals. A self-administered questionnaire sent all participants.Only 30% had received any type formal training on PGx. Of these, only nine...

The current study aims to utilize the concept of hydrophilic–lipophilic balance (HLB) value ingredients for development a stable emulsion-based moisturizing cream and lotion cosmetic application. combination hydrophilic lipophilic emulsifier such as glyceryl stearate (HLB 3.8) PEG-100 18.8) were found be effective emulsify chosen oil phase system at specific concentration achieve required HLB system. developed formulation was characterized pH, viscosity, spreadability, rheology, droplet...

The main user of three dimensional (3D) printing for drug dispensing will be the hospital pharmacist. Yet despite tremendous amount research and industrial initiatives, there is no evaluation pharmacist’s knowledge opinion this technology. present study aimed to assess attitude among pharmacists about 3D technology as an innovative method personalized medicine barriers implementation in Saudi Arabia. We found that 53% participants were aware general, but only 14–16% specific application...

Introduction Patients with carpal tunnel syndrome have a high prevalence of hypothyroidism, therefore, it is recommended to assess thyroid function routinely in patients syndrome. This study aims determine the hypothyroidism among and relate other socio-demographic factors. Methods was retrospective carried out King Fahad Medical City (KFMC) Riyadh, Saudi Arabia. A total 422 samples were collected conveniently from files who underwent release surgery. The Statistical Package for Social...