Introduction Triple-negative breast cancer (TNBC) presents unique challenges indiagnosis and treatment.Resveratrolexhibits potential as a therapeutic intervention for TNBC byregulating various pathways such the PI3K/AKT, RAS/RAF/ERK, PKCδ,and AMPK, leading to apoptosis through ROS-mediated CHOP activationand expression of DR4 DR5. However, clinical efficacy resveratrol is limited due itspoor biopharmaceutical characteristics low bioavailability at thetumor site. Nanotechnology offers...

The oldest remedies identified to mankind are herbal medicines. India is recognized worldwide for its Ayurvedic treatment. has rich history of using many plants medicinal purposes. Remedial cooperating extremely dynamic position in customary drugs the action a variety illness. However key obstacle, which hindered promotion use alternative medicines developed countries, no evidence documentation and absence stringent quality control measures. There demand every investigate effort execute on...

Diabetes, a state of improperly regulated homeostasis carbohydrate and lipid metabolism is one the major killers in recent times. Most prevalent form diabetes non-insulin dependent mellitus (NIDDM/type II). Rapid hydrolysis starch mediated by pancreatic α-amylase α-glucosidases followed glucose uptake at intestine results sudden rise blood levels, causing hyperglycemia type II patients. α-glucosidase inhibitors act as competitive enzymes needed to digest carbohydrates: specifically...

The essential oil of Rosmarinus officinalis L. leaves growing in Erbil, Iraq was investigated by GC/MS. (EO) extracted hydro-distillation method. EO R. leaf examined in-vitro for antidiabetic and anticancer effects. α-glucosidase enzyme inhibition assay performed to determine effects EO. MTT carried out the potential antiproliferative cytotoxic properties yielded 42 constituents amounting 99.84 %. major were verbenone (23.46 %), 1,8-cineol (15.96 α-pinene (12.10 camphor (10.98 bornyl acetate...

The essential oil of Lavandula angustifolia Mill.growing spontaneously in Iraq was investigated by GC and GC/MS for the first time.The extracted from flowers hydro-distillation.Thirty-four components amounting to 98.91 % were identified.The major component being linalool (24.63 %).The other significant constituents camphor (13.58 %), linalyl acetate (8.89 (Z)-β-ocimene (7.59 1,8-cineole (7.14 borneol (6.41 (E)β-ocimene (4.76 hotrienol (4.42 hexyl butyrate (2.96 α-bisabolol (1.13 %)...

Pelargonium graveolens (Geranium) is a source of the finest quality fragrance and its essential oils are used as antibacterial, antifungal agents. The aim current research to determine chemical constituents in oil P. by GC-MS evaluate antidiabetic activity via α-glucosidase inhibition assay. composition was determined GC/MS assessed through enzyme in-vitro models. analysis determines 36 components leaves, citronellyl isovalerate (10.41 %), menthol (9.61 linalool (8.63 p-menthone (6.31...

This review aims to present the information related chemical composition of Momordica charantia Linn.(Cucurbitaceae), which is used in many Asian countries as a traditional functional food and medicine especially for treatment diabetes mellitus.Our main objective was collect about active constituents this plant.Review literature included PubMed searches with ʻMomordica charantiaʼ, ʻBitter gourdʼ or melonʼ initial key words.The search further refined by looking terms such ʻConstituentsʼ (or...

<strong>Objective:</strong> Swertiamarin is a common secoiridoid found among the members of Gentianaceae. The present study aimed to establish effectiveness swertiamarin in achieving glucose homeostasis via inhibition carbohydrate metabolizing enzymes by in-vitro and in-vivo studies. <strong>Materials methods:</strong> was obtained from dried whole plant samples <em>Enicostemma littorale</em> Blume chromatographic fractionation over silica gel column. Its...

Gymnemic acid and charantin are well-established antidiabetic phytosterols found in Gymnema sylvestre Momordica charantia, respectively. The fact that these plants often used together poly-herbal formulations lured us to develop an HPTLC densitometric method for the simultaneous quantification of their bioactive compounds. Indirect estimation gymnemic as gymnemagenin β-sitosterol after hydrolysis has been proposed. Aluminum-backed silica gel 60 F254 plates (20 × 10 cm) were stationary phase...

Lavandula angustifolia is a major source of high-quality fragrance and extensively used in aromatherapy. Lavender widely found the Jammu Kashmir region India. The aim present study to determine chemical constituents essential oil L. flowers by gas chromatography-mass spectrometry evaluate its antihyperglycemic activity via inhibition α-glucosidase enzyme. were determined was evaluated yielded 41 which constitute about 99.28 % total include linalyl acetate (39.28 %), linalool (26.76...

Phytochemical investigation of the methanolic extract stem bark Ficus bengalensis L. (Moraceae) resulted in isolation two new phytoconstituents characterized as lanost-5,24-dien-3β-yl-β-d-glucopyranosid-2′-O-yl-docos-11″-enoate (lanostadienylglucosyl cetoleate) (1) and 3β-acetoxy-stigmast-22-en-26-oic acid (bengalensisteroic ester) (2) together with known compounds heneicosanyl cis-octadec-9-enoate (heneicosanyl oleate) (3), urs-12-en-3β-yl acetate (α-amyrin acetate) (4), lup-20(29)-en-3β-ol...