A5060830800- Health Systems, Economic Evaluations, Quality of Life
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Diabetes Treatment and Management
- Diabetes Management and Research
- Liver Disease Diagnosis and Treatment
- HIV Research and Treatment
- Pharmaceutical studies and practices
- Liver Disease and Transplantation
- Food Allergy and Anaphylaxis Research
- Immunodeficiency and Autoimmune Disorders
- Respiratory and Cough-Related Research
- HIV/AIDS drug development and treatment
- Dermatology and Skin Diseases
- Autoimmune and Inflammatory Disorders Research
- Psoriasis: Treatment and Pathogenesis
- Assisted Reproductive Technology and Twin Pregnancy
- HIV/AIDS Research and Interventions
- Blood properties and coagulation
- Diet, Metabolism, and Disease
- Inhalation and Respiratory Drug Delivery
- Metabolism, Diabetes, and Cancer
- Platelet Disorders and Treatments
- Piperaceae Chemical and Biological Studies
- Plant Disease Management Techniques
University of Pavia
2020-2025
University of Colombo
2024
Center for Outcomes Research and Clinical Epidemiology
2024
Centro Studi Industriali
2013-2023
University of Bergamo
2020-2022
Istituto di Ricerche Economiche e Sociali
2013-2018
IRCCS Humanitas Research Hospital
2018
Hospital de São João
2014
Fondazione Andrea Cesalpino
1994
Sapienza University of Rome
1989
BackgroundAsthma is one of the most common non-communicable respiratory diseases, affecting about 6% general population. Severe asthma, even if afflicts a minority asthmatics, drives majority costs disease. The aim this study to create pharmacoeconomic model predict corticosteroid-related adverse events in severe asthmatics and applying it first published epidemiologic data from Asthma Network Italy (SANI) registry.MethodsThe analysis was conducted perspective Italian National Healthcare...
To evaluate if VSL#3® [a high-concentration multi-strain probiotic mix containing one strain of Streptococcus thermophilus BT01, three strains Bifidobacteria (B. breve BB02; B. animalis subspecies [subsp.] lactis BL03, previously identified as longum BL03; and subsp. BI04, infantis BI04), four Lactobacilli (L. acidophilus BA05, L. plantarum BP06, paracasei BP07, helveticus BD08, delbrueckii bulgaricus BD08)] therapy could improve hepatic parameters.We enrolled 60 Caucasian patients aged ≥ 18...
Abstract Objectives/purpose The costs attributable to antimicrobial resistance (AMR) remain theoretical and largely unspecified. Current figures fail capture the full health economic burden caused by AMR across human, animal, environmental health; historically many studies have considered only direct associated with human infection from a hospital perspective, primarily high-income countries. Global Antimicrobial Resistance Platform for ONE-Burden Estimates (GAP-ON€) network has developed...
In a recent prospective, multicenter, two-arm randomized controlled trial (RCT), we demonstrated that adjunctive reflectance confocal microscopy (RCM) in routine clinical practice provides benefits, including safe melanoma detection and 43.3% reduction the number needed to excise (NNE). A cost-benefit analysis was conducted based on NNEs for standard care (5.3) RCM (3.0). Cost data were supplied by one center, applying micro-costing approach from hospital's perspective. Costs calculated...
The international scientific literature is systematically analyzed in this review over a period of nearly 10 years with respect to the use active hemostat and surgical sealant patch TachoSil, considering its economic effects. It`s an update first published 2014. A PubMed systematic was done from Nov 2013 up December 2022. Based on criteria used select, papers were grouped terms study design, surgery type, reduction time hemostasis, shorter hospital stay, fewer number post-operative...
Background: to evaluate the effects of Vitamin D3 on glyco-metabolic control in type 2 diabetic patients with D deficiency. Methods: one hundred and seventeen were randomized placebo 122 D3. We evaluated anthropometric parameters, control, parathormone (PTH) value at baseline, after 3, 6 months. Results: a significant reduction fasting, post-prandial glucose was recorded group A HbA1c decrease observed (from 7.6% or 60 mmol/mol 7.1% 54 mmol) months compared (p < 0.05 for both). At end study...
In the study reported here, single-tablet regimen (STR) versus (vs) multi-tablet (MTR) strategies were evaluated through a cost analysis in large cohort of patients starting their first highly active antiretroviral therapy (HAART). Adult human immunodeficiency virus (HIV) 1-naïve patients, followed at San Raffaele Hospital, Milan, Italy, first-line from June 2008 to April 2012 included analysis.The most frequently used HAART regimens (>10%) grouped into two classes: 1) STR tenofovir...
Inadequately controlled severe asthma patients require additional therapy accounting for significant clinical and economic burden. Our analysis aims to determine the cost-effectiveness of omalizumab in management allergic Italy based on observational data from PROXIMA study.Observational efficacy, healthcare resource utilization changes quality life at 12 months after initiation were examined estimate compared pre-omalizumab period results expressed with Incremental Cost-Effectiveness Ratio...
Diabetes represents a relevant public health problem worldwide due to its growing prevalence and socioeconomic burden, principally the development of macrovascular microvascular complications as well continuous launch new even more expensive drugs. The aim our study is evaluate economic impact dulaglutide, weekly GLP-1 receptor agonist, on treatment diabetic patients an alternative both high dose sulphonylureas insulin basalization at failure oral therapies alone. We carried out...
The utilization of diagnostic imaging has substantially increased over the past decade in Europe and North America continues to grow worldwide. purpose this study was develop an economic evaluation a syringeless power injector (PI) versus dual-syringe PI for contrast enhanced computed tomography (CECT) hospital setting.Patients (n=2379) were enrolled at Legnano Hospital between November 2012 January 2013. They had been referred CECT analysis randomized into two groups. first group examined...
Diabetes represents a relevant public health problem worldwide due to its increasing prevalence and socioeconomic burden. There is no doubt that tight glycemic control reduces the development of diabetic complications such as long-term costs related disease. The aim our model was calculate total direct associated with two treatments considered in DUAL VII study, hence evaluate potential economic benefits for National Health System (NHS) deriving from use insulin degludec plus liraglutide...
To date, no study evaluated the cost-effectiveness of palbociclib (PAL) plus fulvestrant (FUL) vs ribociclib (RIB) FUL and abemaciclib (ABM) in Italy. Cost-effectiveness analysis comparing three cyclin-dependent 4/6 kinase inhibitors combination with endocrine therapies for management postmenopausal women HR+, HER2- advanced or metastatic breast cancer Italy was developed.To assess PAL RIB ABM FUL, a cost-minimization has been carried out conservative scenario considering CDK4/6 equal...
Secukinumab, a fully human monoclonal IgG1 antibody that selectively neutralizes the proinflammatory cytokine IL-17A, has been approved in Europe 2015 for treatment of adult patients with moderate-to-severe plaque psoriasis, psoriatic arthritis (PsA), and ankylosing spondylitis (AS). This analysis assessed budget impact introduction secukinumab to Italian market all three indications from perspective National Health Service.A cross-indication model was developed included biologic-treated...
In Italy, the adoption of a total lockdown has generated almost suspension outpatient visits except for emergencies. Even after lockdown, pandemic fear created additional barriers to access health services. The aim our study is evaluate economic impact COVID-19 on public in focusing its effects diabetic population.We analyzed excess mortality and morbidity Italian population during 2020. analysis was divided into several steps: quantification specialist visit reduction, calculation...
Background: Tamoxifen (TMX) has been in clinical use for over 40 years and can be considered the standard breast cancer chemoprevention high-risk patients. Unfortunately, patient compliance to treatment is low due systemic toxicity. Objective: The present study demonstrates of a nanochannel Delivery System (nDS) controlled sustained local release TMX mammary tissue. Method: vitro from nDS was assessed using two different concentrations solubilizer PEG400. optimal configuration then studied...
The importance of functional food and nutraceutical products to deal with cardiometabolic diseases (CMDs) metabolic syndrome (MetS) has gained attention in the past few years. aim this narrative review is highlight potential effectiveness improvement CMDs MetS biomarkers, alongside their burden disease economic health expenditure. A science database search was conducted between May June 2021. total 35 studies were included paper. We male female subjects, children, adults, good or...
We investigated the in vitro proliferation of peripheral blood mononuclear cells (PBMC) from Parietaria-allergic subjects, atopic patients with other sensitizations and healthy controls to Parietaria judaica pollen extracts. PBMC almost all 44 divided into five groups (Parietaria-, grass-, Dermatophagoides-sensitive normal individuals) were able proliferate response extract without statistically significant differences between groups. Mean values stimulation indexes for respectively: 10.73,...
Costs may play a role in deciding how and when to start highly active antiretroviral therapy (HAART) naïve patient. The aim of the present study was assess cost- effectiveness treatment with HAART large clinical cohort adults determine potential single-tablet regimens management patients human immunodeficiency virus (HIV). An incremental cost-effectiveness ratio analysis performed, including quality-adjusted life year approach.In total, 741 (females comprising 25.5%) were retrospectively...
Aim of our study is to evaluate the economic impact NASH among diabetic population in Italy and potential benefits treatments that can slow disease progression.A Markov model was conducted from Italian National Healthcare System perspective reporting results at 3, 5, 10 15 years. The included T2DM patients with all stages fibrosis (F0-F3), compensated cirrhosis (CC), decompensated (DCC), hepatocellular carcinoma (HCC), liver transplant (LT), post-LT death. A 1-year cycle length considered,...