A5075880256- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Extracellular vesicles in disease
- Sinusitis and nasal conditions
- MicroRNA in disease regulation
- Renal Transplantation Outcomes and Treatments
- Pediatric health and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Olfactory and Sensory Function Studies
- Vitamin D Research Studies
- Molecular Biology Techniques and Applications
- Otitis Media and Relapsing Polychondritis
- Tracheal and airway disorders
- Renal Diseases and Glomerulopathies
- Mesenchymal stem cell research
- Coastal and Marine Management
- Pregnancy and Medication Impact
- Biomedical Research and Pathophysiology
- Transplantation: Methods and Outcomes
- Antimicrobial Peptides and Activities
- Respiratory and Cough-Related Research
- Mast cells and histamine
- T-cell and B-cell Immunology
- Cytomegalovirus and herpesvirus research
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2018-2024
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2020-2023
Universitat de Barcelona
2020-2023
Instituto de Salud Carlos III
2023
Fundació Clínic per a la Recerca Biomèdica
2018
Obesity and asthma are associated with systemic inflammation maintained by mediators released adipose tissue lung. This study investigated the inflammatory serum mediator profile in obese subjects (O) (n = 35), non-obese (NOA) patients 14), asthmatics (OA) 21) healthy controls (HC) 33). The effect of weight loss after bariatric surgery (BS) was examined 10 OA 31 O subjects. We analyzed markers including leptin, adiponectin, TGF-β1, TNFR2, MCP-1, ezrin, YKL-40, ST2, IL-5, IL-9, IL-18....
Human adult basal stem/progenitor cells (BSCs) obtained from chronic rhinosinusitis with nasal polyps (CRSwNP) when differentiated in an air-liquid interface (ALI) usually provide a pseudostratified airway epithelium similar abnormalities than original vivo phenotype. However, the intrinsic mechanisms regulating this complex process are not well defined and their understanding could offer potential new therapies for CRSwNP (incurable disease).We performed transcriptome-wide analysis during...
Mesenchymal stromal cells (MSCs) from different sources possess great therapeutic potential due to their immunomodulatory properties associated with allograft tolerance. However, a crucial role in this activity resides extracellular vesicles (EVs) and signaling molecules secreted by cells. This study aimed evaluate the of donor recipient MSCs isolated adipose tissue (AD) or bone marrow (BM) EVs on kidney outcome rat transplant model.The heterotopic-kidney-transplant Fisher-to-Lewis model...
Abstract Colorectal cancer (CRC) occurs with more aggressiveness in kidney transplant recipients compared to the general population. Immunosuppressive therapy plays a crucial role development of post-transplant malignancy. Concretely, cyclosporine A (CsA) has intrinsic pro-oncologic properties, while several studies report regression after introduction rapamycin (RAPA). However, their effect on extracellular vesicle (EV) content from CRC cell lines and relevance pre-metastatic niche have not...
In Brief Background The progression from acute to chronic antibody-mediated rejection in kidney transplant recipients is usually not prevented by current therapeutic options. Here, we investigated whether the use of tofacitinib (TOFA), a Janus kinase 3 inhibitor, was capable preventing allograft dysfunction Fisher-to-Lewis rat model transplantation. Methods Rats were treated third week after transplantation allow development rejection. Treatment based on cyclosporin A, rapamycin or TOFA....
Asthma is a complex condition resulting from the interaction of genes and environment. Obesity risk factor to develop asthma contributes poor response therapy severity. The aim study was evaluate effect obesity on expression levels previously associated with severe asthma. Three groups subjects were studied: non-obese asthmatics (NOA), obese patients (OA), non-asthmatic (O). Previously reported overexpressed (IL-10, MSR1, PHLDA1, SERPINB2, CD86) underexpressed (CHI3L1, CPA3, IL-8, PI3) in...
Abstract Background and Aims Fabry's disease (FD), a hereditary condition, is linked to the X chromosome due mutation in gene encoding alpha-galactosidase A (alpha-GalA). This results defect metabolism of glycosphingolipids, leading deposition globotriaosylceramide (GB3) primarily organs such as heart, kidneys, nervous system. Renal injury can affect any level structure, with podocytes being most commonly affected their low regeneration high contact GB3. leads proteinuria, if it exceeds 0.5...
The Platelet-Activating Factor (PAF)/receptor (PAFR) system is involved in asthma and allergic rhinitis; however, its role chronic rhinosinusitis (CRS) still unclear. This study aimed to assess the expression of PAFR concentration Lyso-PAF isoforms nasal polyps (NP) patients suffering from CRS with/without comorbidities such as NSAID-exacerbated respiratory disease (N-ERD) compared healthy mucosa (NM) control subjects. NM (n = 8) NP tissues were obtained undergoing surgery for septal...
Background: Living-donor kidney transplant (LDKT) recipients undergoing desensitization for Human Leukocyte Antigen (HLA)-incompatibility have a high risk of developing antibody-mediated rejection (ABMR). The purpose the study is to evaluate if residual B cell activity after could be estimated by presence circulating cell-derived extracellular vesicles (BEVs). Methods: BEVs were isolated Sepharose-based size exclusion chromatography and defined as CD19+ HLA-II+ vesicles. We analyzed stored...
Obesity is known to impair the efficacy of glucocorticoid medications for asthma control. Glucocorticoid-induced gene expression studies may be useful discriminate those obese asthmatic patients who present a poor response glucocorticoids. The genes interest normalized with respect reference (RGs). Ideally, RGs have stable in different samples and are not affected by experimental conditions. objective this work was analyze suitable study role glucocorticoid-induced further research. eight...
The aggressiveness of colorectal cancer in kidney transplantation is much more significant than the increase its incidence compared with general population. molecular mechanism different immnosuppressive drugs antagonistic antineoplasic properties not well characterized. Exosomes (Ex) are involved tumor immunity, angiogenesis and metastasis. Exosomal miRNAs can affect expression a variety target genes. Our aim to investigate if distinct colon cells treated Cyclosporin A (CsA) Rapamycin...
Introduction: Kidney Transplant Recipients (KTRs) submitted to desensitization for a positive cross-match have high risk of developing AntiBody-Mediated Rejection (ABMR). We hypothesized that residual B cells activity after can be estimated by the presence circulating cells-derived Exosomes (BExos) and this could reflect humoral alloreactivity. Methods: were extracted from stored prospectively collected serum samples means sepharose-based size-exclusion chromatography. BExos defined as CD19+...
<b>Background:</b> Recent studies show the immunomodulatory effect of 1,25-dihydroxyvitamin D<sub>3</sub> (vitD<sub>3</sub>), active form vitamin D. Its deficiency has been described in obesity and is related with less control asthma symptomatology. We hypothesized that vitD<sub>3</sub> treatment could enhance <i>in vitro</i> corticosteroid (CS) response by modifying anti-inflammatory pathways altered obese asthmatic patients. Furthermore, bariatric surgery increase CS sensitivity these...
Abstract MP‐AzeFlu (intranasal fluticasone and azelastine) has been widely studied demonstrated efficacy in Allergic rhinitis with a superior effect compared to these drugs administered individually; however, the mechanism by which produces this improved clinical not yet fully explained. In study, we investigated of propionate (FP) on arachidonic acid metabolism as measured changes regulation cyclooxygenase (COX) isoforms, prostaglandin (PG) D 2 , PGE receptor (EP) 2, EP3. Expression key...