A5028726386- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Stress Responses and Cortisol
- Sleep and Wakefulness Research
- EEG and Brain-Computer Interfaces
- Zebrafish Biomedical Research Applications
- Advanced Wireless Communication Techniques
- Neural Networks and Applications
- Dementia and Cognitive Impairment Research
- Cognitive Science and Mapping
- Scientific Computing and Data Management
- Blind Source Separation Techniques
- Wireless Communication Networks Research
- Functional Brain Connectivity Studies
- Cell Image Analysis Techniques
- Single-cell and spatial transcriptomics
- Neuroinflammation and Neurodegeneration Mechanisms
Howard Hughes Medical Institute
2019-2025
University of California, San Francisco
2019-2024
University of California, Los Angeles
2024
University of Washington
2023
The University of Texas at Austin
2023
Boston University
2012
Representations related to past experiences play a critical role in memory and decision-making processes. The rat hippocampus expresses these types of representations during sharp-wave ripple (SWR) events, previous work identified minority SWRs that contain 'replay' spatial trajectories at ∼20x the movement speed animal. Efforts understand replay typically make multiple assumptions about which events examine what sorts constitute replay. We therefore lack clear understanding both prevalence...
Abstract The hippocampus is a mammalian brain structure that expresses spatial representations 1 and crucial for navigation 2,3 . Navigation, in turn, intricately depends on locomotion; however, current accounts suggest dissociation between hippocampal the details of locomotor processes. Specifically, thought to represent mainly higher-order cognitive variables such as position, speed direction movement 4–7 , whereas limb movements propel animal can be computed represented primarily...
ABSTRACT Executing memory-guided behavior requires both the storage of information about experience and later recall that to inform choices. Awake hippocampal replay, when neural ensembles briefly reactivate a representation related prior experience, has been proposed critically contribute these memory-related processes. However, it remains unclear whether awake replay contributes memory function by promoting past experiences, facilitating planning based on an evaluation those or both. We...
Abstract Scientific progress depends on reliable and reproducible results. Progress can also be accelerated when data are shared re-analyzed to address new questions. Current approaches storing analyzing neural typically involve bespoke formats software that make replication, as well the subsequent reuse of data, difficult if not impossible. To these challenges, we created Spyglass , an open-source framework enables analyses sharing both intermediate final results within across labs. uses...
Abstract Decoding algorithms provide a powerful tool for understanding the firing patterns that underlie cognitive processes such as motor control, learning, and recall. When implemented in context of real-time system, decoders also make it possible to deliver feedback based on representational content ongoing neural activity. That turn allows experimenters test hypotheses about role driving downstream activity behaviors. While multiple systems have been developed, they are typically C++...
The cognitive ability to go beyond the present consider alternative possibilities, including potential futures and counterfactual pasts, can support adaptive decision making. Complex changing real-world environments, however, have many possible alternatives. Whether how brain select among them represent alternatives that meet current needs remains unknown. We therefore examined neural representations of spatial locations in rat hippocampus during navigation a complex patch foraging...
The brain has the remarkable ability to learn and guide performance of complex tasks. Decades lesion studies suggest that different regions perform specialized functions in support behaviors. Yet recent large-scale neural activity reveal similar patterns encoding distributed widely throughout brain. How these are compatible with regional specialization function remains unclear. Two frontal regions, dorsal medial prefrontal cortex (dmPFC) orbitofrontal (OFC), a paradigm this conundrum. In...
Hippocampal replay – the time-compressed, sequential reactivation of ensembles neurons related to past experience is a key neural mechanism memory consolidation. Replay typically coincides with characteristic pattern local field potential activity, sharp-wave ripple (SWR). Reduced SWR rates are associated cognitive impairment in multiple models neurodegenerative disease, suggesting that clinically viable intervention promote SWRs and would prove beneficial. We therefore developed...
Hippocampal replay – the time-compressed, sequential reactivation of ensembles neurons related to past experience is a key neural mechanism memory consolidation. Replay typically coincides with characteristic pattern local field potential activity, sharp-wave ripple (SWR). Reduced SWR rates are associated cognitive impairment in multiple models neurodegenerative disease, suggesting that clinically viable intervention promote SWRs and would prove beneficial. We therefore developed...
Abstract Representations related to past experiences play a critical role in memory and decision-making processes. The rat hippocampus expresses these types of representations during sharp-wave ripple (SWR) events, previous work identified minority SWRs that contain “replay” spatial trajectories at ~20x the movement speed animal. Efforts understand replay typically make multiple assumptions about which events examine what sorts constitute replay. We therefore lack clear understanding both...
In the hippocampus, replay sequences are temporally compressed patterns of neural spiking that resemble occur when animal is moving through environment. Because typically at rest, hypothesized to be part an internal cognitive process enables retrieval past spatial memories and planning future movement. Traditionally, have been discovered by identifying sharp wave ripples (SWRs)-high frequency oscillations in association with replay-and then looking within SWRs for spatially continuous...
Denovellis et al., (2022). Spectral Connectivity: a python package for computing multitaper spectral estimates and frequency-domain brain connectivity measures on the CPU GPU. Journal of Open Source Software, 7(80), 4840, https://doi.org/10.21105/joss.04840
Humans can remember specific remote events without acting on them and influence which memories are retrieved based internal goals. However, animal models typically present sensory cues to trigger memory retrieval then assess action. Thus, it is difficult determine whether measured neural activity patterns relate the cue(s), memory, or behavior. We therefore asked retrieval-related could be generated in animals a behavioral report. focused hippocampal "place cells" primarily represent...
Hippocampal replay – the time-compressed, sequential reactivation of ensembles neurons related to past experience is a key neural mechanism memory consolidation. Replay typically coincides with characteristic pattern local field potential activity, sharp-wave ripple (SWR). Reduced SWR rates are associated cognitive impairment in multiple models neurodegenerative disease, suggesting that clinically viable intervention promote SWRs and would prove beneficial. We therefore developed...
Summary paragraph The hippocampus is a vertebrate brain structure that expresses spatial representations 1 and critical for navigation 2,3 . Navigation in turn intricately depends on locomotion; however, current accounts suggest dissociation between hippocampal the details of locomotor processes. Specifically, thought to primarily represent higher-order cognitive variables like position, speed, direction movement 4–7 , while limb movements propel animal are be computed represented...
SUMMARY Hippocampal replay – the time-compressed, sequential reactivation of ensembles neurons related to past experience is a key neural mechanism memory consolidation. Replay typically coincides with characteristic pattern local field potential activity, sharp-wave ripple (SWR). Reduced SWR rates are associated cognitive impairment in multiple models neurodegenerative disease, suggesting that clinically viable intervention promote SWRs and would prove beneficial. We therefore developed...
Hippocampal replay – the time-compressed, sequential reactivation of ensembles neurons related to past experience is a key neural mechanism memory consolidation. Replay typically coincides with characteristic pattern local field potential activity, sharp-wave ripple (SWR). Reduced SWR rates are associated cognitive impairment in multiple models neurodegenerative disease, suggesting that clinically viable intervention promote SWRs and would prove beneficial. We therefore developed...