A5100650166- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Wnt/β-catenin signaling in development and cancer
- Cell death mechanisms and regulation
- Fatigue and fracture mechanics
- Erythrocyte Function and Pathophysiology
- Parasite Biology and Host Interactions
- Curcumin's Biomedical Applications
- 14-3-3 protein interactions
- Developmental Biology and Gene Regulation
- Cancer-related gene regulation
- RNA Research and Splicing
- Blood disorders and treatments
- Toxin Mechanisms and Immunotoxins
- Nanoparticles: synthesis and applications
- Endoplasmic Reticulum Stress and Disease
- Zebrafish Biomedical Research Applications
- Bioinformatics and Genomic Networks
- Cancer, Hypoxia, and Metabolism
- Trace Elements in Health
- Animal Genetics and Reproduction
- Mechanisms of cancer metastasis
- Selenium in Biological Systems
- Cardiac Fibrosis and Remodeling
Yan'an University
2021
Jinzhou Medical University
2013-2021
Kunming Medical University
2018-2021
Affiliated Hospital of Jining Medical University
2020
Tianjin University of Science and Technology
2020
Luoyang Central Hospital Affiliated to Zhengzhou University
2020
Second Affiliated Hospital of Kunming Medical College
2018
Jiangsu Province Hospital
2013
Objectives This study was designed to investigate the role of circ_0078767/miR‐330‐3p/RASSF1A in non‐small‐cell lung cancer (NSCLC). Bioinformatic analysis performed screen for differentially expressed genes NSCLC tissues from adjacent tissues. Materials and Methods qRT‐PCR used detect RNA expression cells tissues, Western blot conducted determine protein levels RASSF1A cells. A miRanda algorithm predict targeted relationship among RNAs. dual‐luciferase reporter gene assay verify...
Radioresistance is a crucial factor for the failure of iodine 131 ( I)-based radiotherapy differentiated thyroid carcinoma (DTC). This study aimed to explore effect circ_NEK6 on development I resistance in DTC and its potential mechanism. In this study, we demonstrated that expression was significantly elevated I-resistant tissues cell lines. Knockdown repressed via inhibiting proliferation, migration, invasion abilities, inducing apoptosis DNA damage cells. Mechanistically, knockdown...
The pathogenesis of GC involves the complex networking multiple signaling pathways; however, detailed mechanisms tumorigenesis remains largely unknown. Therefore, it is necessary to explore novel diagnostic/prognostic biomarkers for GC. In this study, levels hsa_circRNA_100269 in gastric cancer (GC) samples and cells were examined, its effects on biological functions elucidated. specimens/cell lines examined using RT-qPCR. Cell models with overexpression or knockdown generated lentiviral...
Receptor of activated C Kinase 1 (RACK1) is an essential scaffold and anchoring protein, which serves important role in multiple tumorigenesis signaling pathways. The present study aimed to investigate the expression RACK1 gastric cancer (GC), its association with occurrence development GC. In addition, effect mechanism overexpression on growth, proliferation GC cells was examined. Firstly, protein detected 70 cases tissues 30 noncancerous using immunohistochemical staining, between clinical...
Notch and Wnt signaling play critical roles in the regulation of development diseases. Several studies have previously reported that may be a therapeutic target treatment various types human cancer. In this study, we report activation Notch1 inhibits proliferation BGC-823 gastric cancer cells. However, Wnt/β‑catenin pathway promotes growth Furthermore, combinational two pathways These data suggest overcomes pro-apoptotic role
To investigated the role of Mailuoning in prevention high-glucose-mediated cell apoptosis human umbilical vein endothelial cells (HUVEC) and mechanisms involved. MTT assay was used to investigate viability, western blot protein expression, flow cytometric detection technology detect apoptosis. Exposure HUVEC high glucose (50 mM) significantly suppressed viability increased compared with normal (11 (all P<0.05). However, prevented high-glucose-induced dose-dependent manner. Further studies...
<title>Abstract</title> The authors have requested that this preprint be removed from Research Square.
Objective To investigate the expression of protein kinase CK2α in thyroid carcinoma SW579 cells and its significance.Methods Hacat were cultured vitro levels mRNA measured by reverse transcription-polymerase chain reaction (RT-PCR) Western blotting.Moreover,CK2 activity was also measured.Results It showed that (0.92 ±0.01 vs 0.52 ±0.02,t =19.24,P ＜0.01)and protein(0.98 0.37 =24.14,P ＜0.01) CK2αwere significantly stronger relative to cells.Conclusions Formation development may be connection...
Abstract Background: The expression of circRNA_100269 in gastric cancer (GC) tissues and cells, together with its regulatory roles on GC cells were investigated. Methods: levels matched para-carcinoma tissues, as well human cell lines normal epithelial evaluated using RT-qPCR. models overexpression or knockdown generated lentiviral vectors. Cell viability was examined MTT assay; migration invasive activity determined by wound healing Transwell assay. cycle arrest apoptosis assessed;...
Abstract Background: The expression of circRNA_100269 in gastric cancer (GC) tissues and cells, together with its regulatory roles on GC cells were investigated. Methods: levels matched para-carcinoma tissues, as well human cell lines normal epithelial evaluated using RT-qPCR. models overexpression or knockdown generated lentiviral vectors. Cell viability was examined MTT assay; migration invasive activity determined by wound healing Transwell assay. cycle arrest apoptosis assessed;...
Abstract Background: The expression of circRNA_100269 in gastric cancer (GC) tissues and cells, together with its regulatory roles on GC cells were investigated. Methods: levels matched para-carcinoma tissues, as well human cell lines normal epithelial evaluated using RT-qPCR. models overexpression or knockdown generated lentiviral vectors. Cell viability was examined MTT assay; migration invasive activity determined by wound healing Transwell assay. cycle arrest apoptosis assessed;...
Avermectin is a widely used insecticide, and it mainly acts against animal parasites insects. Because of its extensive use in agriculture, large amount avermectin accumulated natural waters. neurotoxin that affects the autonomous behavior zebrafish inhibits neurological responses invertebrates through GABA-chloride channels. In this study, we as model organism to explore teratogenic lethal effects different concentrations avermectin. We found 50 μg/L could significantly cause malformation...