A5014004722- Streptococcal Infections and Treatments
- Bacterial Infections and Vaccines
- Helicobacter pylori-related gastroenterology studies
- Neonatal and Maternal Infections
- RNA modifications and cancer
- Essential Oils and Antimicrobial Activity
- Metabolism and Genetic Disorders
- Digestive system and related health
- Cancer-related gene regulation
- DNA and Nucleic Acid Chemistry
- RNA Interference and Gene Delivery
- Alcoholism and Thiamine Deficiency
- Telomeres, Telomerase, and Senescence
- Genetic factors in colorectal cancer
- Microbial Inactivation Methods
- Listeria monocytogenes in Food Safety
- RNA and protein synthesis mechanisms
- Mitochondrial Function and Pathology
Centre National de la Recherche Scientifique
2019-2024
Inserm
2019-2024
Institut Cochin
2019-2024
Université Paris Cité
2019-2021
Institut Pasteur
2019
Délégation Paris 7
2019
Universidade do Porto
2014
Helicobacter pylori (Hp) is a major risk factor for gastric cancer (GC). Hp promotes DNA damage and proteasomal degradation of p53, the guardian genome stability. reduces expression transcription USF1 shown to stabilise p53 in response genotoxic stress. We investigated whether Hp-mediated deregulation impacts p53-response consequently genetic instability. also explored vivo role carcinogenesis.Human epithelial cell lines were infected with Hp7.13, exposed or not DNA-damaging agent...
Group B Streptococcus (GBS) is the major cause of human neonatal infections. A single clone, designated CC17-GBS, accounts for more than 80% meningitis cases, most severe form infection. However, events allowing blood-borne GBS to penetrate brain remain largely elusive. In this study, we identified host transmembrane receptors α5β1 and αvβ3 integrins as ligands Srr2, a CC17-GBS-specific adhesin. Two motifs located in binding region Srr2 were responsible interaction between CC17-GBS these...
Group B Streptococcus (GBS) is the leading cause of neonatal meningitis responsible for a substantial death and disability worldwide. The vast majority GBS cases are due to CC17 hypervirulent clone. However, cellular molecular pathways involved in brain invasion by isolates remain largely elusive. Here, we studied specific interaction clone with choroid plexus, main component blood-cerebrospinal fluid (CSF) barrier. or non-CC17 strains plexus cells was using an vivo mouse model vitro models...
AbstractListeria monocytogenes (Lm) is a human intracellular pathogen widely used to uncover the mechanisms evolved by pathogens establish infection. However, its capacity perturb host cell cycle was never reported. We show that Lm infection affects progression, increasing overall duration but allowing consecutive rounds of division. A complete infectious induces S-phase delay accompanied slower rate DNA synthesis and increased levels strand breaks. Additionally, damage/replication...
ABSTRACT Background Group B Streptococcus (GBS) is the leading cause of neonatal meningitis responsible for a substantial death and disability worldwide. The vast majority GBS cases are due to CC17 hypervirulent clone. However, cellular molecular pathways involved in brain invasion by isolates remain largely elusive. Here, we studied specific interaction clone with choroid plexus, main component blood-cerebrospinal fluid (CSF) barrier. Methods or non-CC17 strains plexus cells was using an...
Helicobacter pylori infection causes chronic gastritis and is the major risk factor of gastric cancer. H. induces a inflammation-producing reactive oxygen species (ROS) which source chromosome instabilities contributes to development malignancy. also promotes DNA hypermethylation, known dysregulate essential genes that maintain genetic stability. The maintenance telomere length by telomerase for integrity. Telomerase reverse transcriptase (TERT) catalytic component activity an important...