Lei Zhang

ORCID: 0000-0003-4641-6565
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About
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Research Areas
  • Immune Response and Inflammation
  • Pharmacological Effects of Natural Compounds
  • Sperm and Testicular Function
  • Tea Polyphenols and Effects
  • Radiomics and Machine Learning in Medical Imaging
  • NF-κB Signaling Pathways
  • Exercise and Physiological Responses
  • Adipokines, Inflammation, and Metabolic Diseases
  • Reproductive Health and Technologies
  • Medical Research and Treatments
  • Liver Disease Diagnosis and Treatment
  • Head and Neck Cancer Studies
  • Medical Imaging Techniques and Applications
  • Healthcare and Venom Research
  • Asthma and respiratory diseases
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Natural Antidiabetic Agents Studies
  • interferon and immune responses
  • Animal Nutrition and Physiology
  • Phytochemistry and Biological Activities
  • Bioactive Compounds and Antitumor Agents
  • Reproductive Biology and Fertility
  • Contact Dermatitis and Allergies
  • Salivary Gland Tumors Diagnosis and Treatment
  • Chemical Synthesis and Analysis

Sichuan Academy of Traditional Chinese Medicine
2011-2024

Shanghai University of Medicine and Health Sciences
2022

Pudong New Area People's Hospital
2022

Chengdu University of Traditional Chinese Medicine
2016-2022

Southwest Medical University
2022

Nanjing University
2020

Inner Mongolia Medical University
2020

Fourth Affiliated Hospital of Anhui Medical University
2018

Anhui Medical University
2018

Peking University
2014

Polysialic acid (polySia) is a unique linear homopolymer of α2,8-linked sialic that has been studied extensively as posttranslational modification neural cell adhesion molecule in the central nervous system. Only two proteins are known to be polysialylated cells immune system: CD56 on human natural killer and murine bone marrow (BM) leukocytes, neuropilin-2 (NRP-2) dendritic (DCs). We tested hypothesis polySia expression regulated during maturation migration leukocytes plays role functional...

10.1093/glycob/cwu050 article EN Glycobiology 2014-05-27

10.1046/j.1523-1747.2000.00999.x article EN publisher-specific-oa Journal of Investigative Dermatology 2000-08-01

A positive surgical margin (PSM) following oral cancer resection results in local recurrence and poor prognosis. Mono-block tumor specimens, especially from the base, are difficult to evaluate. This inaccurate sampling ultimately leads a false pathological diagnosis. Lugol's iodine (I2-IK)-enhanced micro-CT is an emerging method image specimens. study explores feasibility of I2-IK-enhanced evaluate for tongue squamous cell carcinoma (TSCC) specimens further seek optimal staining...

10.3389/fonc.2020.550171 article EN cc-by Frontiers in Oncology 2020-10-21

Infectious pneumonia is one of the important causes neonatal death that can lead to imbalance T helper 17 cells (Th17) and regulatory (Treg) cells. The correlation between plasma fibrinogen (FIB), procalcitonin (PCT), C-reactive protein (CRP) Th17/Treg-IL-10/IL-17 axis balance their specific role in occurrence development infectious are not completely clear.Thirty specific-pathogen free Sprague Dawley (SD) rats were randomly divided into a control group for comparison IPN model group. After...

10.21037/tp-21-565 article EN Translational Pediatrics 2022-01-01

In the injured liver, hepatic stellate cells (HSCs) induce immunosuppression activity and thus participate in pathogenesis of liver disease, including HCC. Therefore, finding new drugs to inhibit their is necessary. This study tests whether bear bile can affect activities HSCs.The mice were gavaged with for 4 weeks. The expression HSCs was detected through desmin ±-smooth muscle antibody immunohistochemistry. isolated from these then cultured T a mixed leukocyte reaction 3 days. Stellate...

10.5754/hge10637 article EN PubMed 2012-06-12

This study aims to explore the protective effect of Forsythiae Fructus extract(FFE) against herpes simplex virus encephalitis(HSE) in mice. To be specific, life extension rate mice, viral load mouse brain, levels tumor necrosis factor-α(TNF-α), interleukin-1β(IL-1β), and interferon-α(IFN-α), nitric oxide(NO) content brain were determined. Mice classified into normal group, model acyclovir(ACV) high-dose, medium-dose, low-dose(100, 50, 25 mg·kg~(-1), respectively) FFE groups. HSE was induced...

10.19540/j.cnki.cjcmm.20220124.401 article EN PubMed 2022-06-01

This paper explores Mongolian medicine processing methods and the use regularity of excipient by text mining techniques. Relevant books were consulted to collect data on excipient, select based noun frequency statistics. Microsoft Excel 2010 software was used for statistical analysis usage different types medicinal materials in periods. And Cytoscape 3.6.1 visual presentation. The topological showed top five net production, development, frying, calcining cooking, fresh milk, wine, urine,...

10.19540/j.cnki.cjcmm.20200522.302 article EN PubMed 2020-08-01

ABSTRACT Toll-like receptors (TLRs) can recognize molecular patterns associated with microorganisms and induce immune responses. TLR3 is responsible for recognizing viruses making hosts resistant to Coxsackie B3 (CVB3) infection. In this study, we found that Tectorigenin Sodium Sulfonate (TSS) has a inhibitory effect exerts strong anti-CVB3 activity through the pathway both in vivo vitro. Balb/c mice were infected by ip injection of CVB3 virus, subcutaneously injected TSS at 264mg·Kg -1 ·d 7...

10.1101/2022.03.28.486160 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2022-03-29
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